Your browser is unable to support new features implemented in HTML5 and CSS3 to render this site as intended. Your experience may suffer from functionality degradation but the site should remain usable. We strongly recommend the latest version of Google Chrome, OS X Safari or Mozilla Firefox. As Safari is bundled with OS X, if you are unable to upgrade to a newer version of OS X, we recommend using an open source browser. Dismiss message
IPR027482 is a Sec1-like, domain 2.
<p>This entry represents domain 2 from the Sec1 family which includes Sec1, Sly1, Slp1/Vps33, yeast Vps45/Stt10, Unc-18 from nematodes, Munc-18b/muSec1, Munc-18c from mouse, Rop from Drosophila, Munc-18/n-Sec1/rbSec1A and rbSec1B from rat [[cite:PUB00027426], [cite:PUB00097356], [cite:PUB00097357], [cite:PUB00058518]].</p> <p>Sec1-like molecules have been implicated in a variety of eukaryotic vesicle transport processes including neurotransmitter release by exocytosis [[cite:PUB00003457]]. They regulate vesicle transport by binding to a t-SNARE from the syntaxin family. This process is thought to prevent SNARE complex formation, a protein complex required for membrane fusion. Whereas Sec1 molecules are essential for neurotransmitter release and other secretory events, their interaction with syntaxin molecules seems to represent a negative regulatory step in secretion [[cite:PUB00007149]].</p> <p>The nSec1 polypeptide chain can be divided into three domains. The first domain, consists of a five-stranded parallel β-sheet flanked by five α-helices. The second domain, like the first one, has an α-β-α fold, however the β-sheet of domain 2 features five parallel strands with an additional antiparallel strand on one edge. The third domain is a large insertion between the third and fourth parallel strands of domain 2, and can be subdivided in two [[cite:PUB00024251]].</p>
This description is obtained from EB-eye REST.
Transcript | Name | Description | Predicted domains | Domain count |
---|---|---|---|---|
– | SNARE-interacting protein KEULE [Medicago truncatula] gi|357477033|ref|XP_003608802.1| | 12 | ||
– | PREDICTED: SNARE-interacting protein KEULE-like [Glycine max] gi|356514152|ref|XP_003525770.1| | 9 | ||
– | PREDICTED: SNARE-interacting protein KEULE-like [Glycine max] gi|356514152|ref|XP_003525770.1| | 9 | ||
– | PREDICTED: SNARE-interacting protein KEULE-like isoform X2 [Cicer arietinum] gi|502160145|ref|XP_004511648.1| | 13 | ||
– | PREDICTED: vacuolar protein sorting-associated protein 45 homolog [Glycine max] gi|356509320|ref|XP_003523398.1| | 9 | ||
– | Vesicle docking involved in exocytosis isoform 1 [Theobroma cacao] gi|508700976|gb|EOX92872.1| | 9 | ||
– | PREDICTED: protein transport Sec1a-like [Cicer arietinum] gi|502146555|ref|XP_004506504.1| | 10 | ||
– | PREDICTED: SEC1 family transport protein SLY1-like [Glycine max] gi|356512111|ref|XP_003524764.1| | 13 | ||
– | PREDICTED: vacuolar protein sorting-associated protein 33 homolog [Cicer arietinum] gi|502118380|ref|XP_004496238.1| | 13 | ||
– | Vacuolar protein sorting-associated protein 45 like; TAIR: AT1G77140.1 vacuolar protein sorting 45; Swiss-Prot: sp|O49048|VPS45_ARATH Vacuolar protein sorting-associated protein 45 homolog; TrEMBL-Plants: tr|A0A151QRQ6|A0A151QRQ6_CAJCA Vacuolar protein sorting-associated protein 45 isogeny; Found in the gene: LotjaGi1g1v0274000 | 14 | ||
– | Vacuolar protein sorting-associated protein 45 like; TAIR: AT1G77140.1 vacuolar protein sorting 45; Swiss-Prot: sp|O49048|VPS45_ARATH Vacuolar protein sorting-associated protein 45 homolog; TrEMBL-Plants: tr|A0A151QRQ6|A0A151QRQ6_CAJCA Vacuolar protein sorting-associated protein 45 isogeny; Found in the gene: LotjaGi1g1v0274000 | 14 | ||
– | SNARE-interacting protein KEULE; TAIR: AT1G12360.1 Sec1/munc18-like (SM) proteins superfamily; Swiss-Prot: sp|Q9C5X3|KEULE_ARATH SNARE-interacting protein KEULE; TrEMBL-Plants: tr|I1LGL2|I1LGL2_SOYBN Uncharacterized protein; Found in the gene: LotjaGi2g1v0427100 | 16 | ||
– | SNARE-interacting protein KEULE; TAIR: AT1G12360.1 Sec1/munc18-like (SM) proteins superfamily; Swiss-Prot: sp|Q9C5X3|KEULE_ARATH SNARE-interacting protein KEULE; TrEMBL-Plants: tr|K7K529|K7K529_SOYBN Uncharacterized protein; Found in the gene: LotjaGi2g1v0427100 | 13 | ||
– | SNARE-interacting protein KEULE; TAIR: AT1G12360.1 Sec1/munc18-like (SM) proteins superfamily; Swiss-Prot: sp|Q9C5X3|KEULE_ARATH SNARE-interacting protein KEULE; TrEMBL-Plants: tr|K7K529|K7K529_SOYBN Uncharacterized protein; Found in the gene: LotjaGi2g1v0427100 | 17 | ||
– | Sec1 family domain-containing protein 2; TAIR: AT2G42700.1 vesicle docking protein; Swiss-Prot: sp|F4IP69|MIP3_ARATH Sec1 family domain-containing protein MIP3; TrEMBL-Plants: tr|A0A0B2RP02|A0A0B2RP02_GLYSO Sec1 family domain-containing protein 2; Found in the gene: LotjaGi3g1v0252400 | 9 | ||
– | Sec1 family domain-containing protein 2; TAIR: AT2G42700.1 vesicle docking protein; Swiss-Prot: sp|F4IP69|MIP3_ARATH Sec1 family domain-containing protein MIP3; TrEMBL-Plants: tr|A0A0B2RP02|A0A0B2RP02_GLYSO Sec1 family domain-containing protein 2; Found in the gene: LotjaGi3g1v0252400 | 9 | ||
– | Sec1 family domain-containing protein 2; TAIR: AT2G42700.1 vesicle docking protein; Swiss-Prot: sp|F4IP69|MIP3_ARATH Sec1 family domain-containing protein MIP3; TrEMBL-Plants: tr|A0A0B2RP02|A0A0B2RP02_GLYSO Sec1 family domain-containing protein 2; Found in the gene: LotjaGi3g1v0252400 | 9 | ||
– | Sec1 family domain-containing protein 2; TAIR: AT2G42700.1 vesicle docking protein; Swiss-Prot: sp|F4IP69|MIP3_ARATH Sec1 family domain-containing protein MIP3; TrEMBL-Plants: tr|A0A0B2RP02|A0A0B2RP02_GLYSO Sec1 family domain-containing protein 2; Found in the gene: LotjaGi3g1v0252400 | 8 | ||
– | SEC1 family transport protein SLY1; TAIR: AT2G17980.1 Sec1/munc18-like (SM) proteins superfamily; Swiss-Prot: sp|Q9SL48|SLY1_ARATH SEC1 family transport protein SLY1; TrEMBL-Plants: tr|K7KPU4|K7KPU4_SOYBN Uncharacterized protein; Found in the gene: LotjaGi4g1v0029100 | 16 | ||
– | SEC1 family transport protein SLY1; TAIR: AT2G17980.1 Sec1/munc18-like (SM) proteins superfamily; Swiss-Prot: sp|Q9SL48|SLY1_ARATH SEC1 family transport protein SLY1; TrEMBL-Plants: tr|K7KPU4|K7KPU4_SOYBN Uncharacterized protein; Found in the gene: LotjaGi4g1v0029100 | 16 | ||
– | SEC1 family transport protein SLY1; TAIR: AT2G17980.1 Sec1/munc18-like (SM) proteins superfamily; Swiss-Prot: sp|Q9SL48|SLY1_ARATH SEC1 family transport protein SLY1; TrEMBL-Plants: tr|K7KPU4|K7KPU4_SOYBN Uncharacterized protein; Found in the gene: LotjaGi4g1v0029100 | 16 | ||
– | SEC1 family transport protein SLY1; TAIR: AT2G17980.1 Sec1/munc18-like (SM) proteins superfamily; Swiss-Prot: sp|Q9SL48|SLY1_ARATH SEC1 family transport protein SLY1; TrEMBL-Plants: tr|K7KPU4|K7KPU4_SOYBN Uncharacterized protein; Found in the gene: LotjaGi4g1v0029100 | 16 | ||
– | SEC1 family transport protein SLY1; TAIR: AT2G17980.1 Sec1/munc18-like (SM) proteins superfamily; Swiss-Prot: sp|Q9SL48|SLY1_ARATH SEC1 family transport protein SLY1; TrEMBL-Plants: tr|K7KPU4|K7KPU4_SOYBN Uncharacterized protein; Found in the gene: LotjaGi4g1v0029100 | 13 | ||
– | SNARE-interacting KEULE-like protein; TAIR: AT1G12360.1 Sec1/munc18-like (SM) proteins superfamily; Swiss-Prot: sp|Q9C5X3|KEULE_ARATH SNARE-interacting protein KEULE; TrEMBL-Plants: tr|G7JLB0|G7JLB0_MEDTR SNARE-interacting KEULE-like protein; Found in the gene: LotjaGi4g1v0213400 | 15 | ||
– | SNARE-interacting KEULE-like protein; TAIR: AT1G12360.1 Sec1/munc18-like (SM) proteins superfamily; Swiss-Prot: sp|Q9C5X3|KEULE_ARATH SNARE-interacting protein KEULE; TrEMBL-Plants: tr|G7JLB0|G7JLB0_MEDTR SNARE-interacting KEULE-like protein; Found in the gene: LotjaGi4g1v0213400 | 15 | ||
– | SNARE-interacting KEULE-like protein; TAIR: AT1G12360.1 Sec1/munc18-like (SM) proteins superfamily; Swiss-Prot: sp|Q9C5X3|KEULE_ARATH SNARE-interacting protein KEULE; TrEMBL-Plants: tr|G7JLB0|G7JLB0_MEDTR SNARE-interacting KEULE-like protein; Found in the gene: LotjaGi4g1v0213400 | 15 | ||
– | SNARE-interacting KEULE-like protein; TAIR: AT1G12360.1 Sec1/munc18-like (SM) proteins superfamily; Swiss-Prot: sp|Q9C5X3|KEULE_ARATH SNARE-interacting protein KEULE; TrEMBL-Plants: tr|G7JLB0|G7JLB0_MEDTR SNARE-interacting KEULE-like protein; Found in the gene: LotjaGi4g1v0213400 | 15 | ||
– | SNARE-interacting KEULE-like protein; TAIR: AT1G12360.1 Sec1/munc18-like (SM) proteins superfamily; Swiss-Prot: sp|Q9C5X3|KEULE_ARATH SNARE-interacting protein KEULE; TrEMBL-Plants: tr|G7JLB0|G7JLB0_MEDTR SNARE-interacting KEULE-like protein; Found in the gene: LotjaGi4g1v0213400 | 15 | ||
– | SNARE-interacting KEULE-like protein; TAIR: AT1G12360.1 Sec1/munc18-like (SM) proteins superfamily; Swiss-Prot: sp|Q9C5X3|KEULE_ARATH SNARE-interacting protein KEULE; TrEMBL-Plants: tr|G7JLB0|G7JLB0_MEDTR SNARE-interacting KEULE-like protein; Found in the gene: LotjaGi4g1v0213400 | 15 | ||
– | Vacuolar protein-sorting-associated protein 33-like protein; TAIR: AT3G54860.1 Sec1/munc18-like (SM) proteins superfamily; Swiss-Prot: sp|Q94KJ7|VPS33_ARATH Vacuolar protein-sorting-associated protein 33 homolog; TrEMBL-Plants: tr|V7BXY6|V7BXY6_PHAVU Uncharacterized protein; Found in the gene: LotjaGi5g1v0270800 | 18 |
A list of co-occurring predicted domains within the L. japonicus gene space:
Predicted domain | Source | Observations | Saturation (%) |
---|---|---|---|
TRANSMEMBRANE | Phobius | 1 | 3.33 |