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GO:0002151

View this GO term in other databases

Overview

Field Value
Namespace Molecular function
Short description G-quadruplex RNA binding
Full defintion Interacting selectively and non-covalently with G-quadruplex RNA structures, in which groups of four guanines adopt a flat, cyclic hydrogen-bonding arrangement known as a guanine tetrad.
Subterm of

Relationships

The relationship of GO:0002151 with other GO terms.

Relationship type GO terms
Is a
Regulates n.a.
Part of n.a.
Positively regulates n.a.
Negatively regulates n.a.

Ancestor tree

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Additional data

This table contains additional metadata associated with the GO entry's definition field.

Field Value
PMID
Function and targeting of G-quadruplexes.Wong HM, Payet L, Huppert JL
Curr Opin Mol Ther. 2009 Apr; 11 (2): 146–55.PMID: 19330720

Guanine-rich sequences of DNA and RNA may fold in vitro and in vivo into G-quadruplexes, four-stranded helical structures held together by a guanine core. G-quadruplexes have various biological functions, including inhibition of telomerase and the regulation of gene transcription and translation, and have become an active target for drug development, particularly for novel anticancer therapies. The physiological functions of G-quadruplexes are discussed in this review and the current knowledge of G-quadruplex ligand and drug development is outlined.

Associated Lotus transcripts 3

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .

Transcript Name Description GO terms GO count
LotjaGi1g1v0424900.1
– Forkhead-associated (FHA) domain protein; TAIR: AT3G54350.1 Forkhead-associated (FHA) domain-containing protein; Swiss-Prot: sp|Q96EZ8|MCRS1_HUMAN Microspherule protein 1; TrEMBL-Plants: tr|K7KHS6|K7KHS6_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0424900
GO terms
3
LotjaGi1g1v0424900.2
– Microspherule protein 1; TAIR: AT3G54350.1 Forkhead-associated (FHA) domain-containing protein; Swiss-Prot: sp|Q96EZ8|MCRS1_HUMAN Microspherule protein 1; TrEMBL-Plants: tr|K7KHS6|K7KHS6_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0424900
GO terms
3
LotjaGi4g1v0124300.1
– Forkhead-associated (FHA) domain protein; TAIR: AT3G54350.1 Forkhead-associated (FHA) domain-containing protein; Swiss-Prot: sp|Q96EZ8|MCRS1_HUMAN Microspherule protein 1; TrEMBL-Plants: tr|V7CD65|V7CD65_PHAVU Uncharacterized protein; Found in the gene: LotjaGi4g1v0124300
GO terms
3

Co-occuring GO terms 1

A list of co-occurring GO terms within the L. japonicus gene space:

GO term Namespace Name Observations Saturation (%)
GO:0071339
Cellular component MLL1 complex 1 33.33