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GO:0016442

View this GO term in other databases

Overview

Field Value
Namespace Cellular component
Short description RISC complex
Full defintion A ribonucleoprotein complex that contains members of the Argonaute family of proteins, small interfering RNAs (siRNAs) or microRNAs (miRNAs), and miRNA or siRNA-complementary mRNAs, in addition to a number of accessory factors. The RISC complex is involved in posttranscriptional repression of gene expression through downregulation of translation or induction of mRNA degradation.
Subterm of

Relationships

The relationship of GO:0016442 with other GO terms.

Relationship type GO terms
Is a
Regulates n.a.
Part of n.a.
Positively regulates n.a.
Negatively regulates n.a.

Ancestor tree

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Additional data

This table contains additional metadata associated with the GO entry's definition field.

Field Value
PMID
miRNAs on the move: miRNA biogenesis and the RNAi machinery.Murchison EP, Hannon GJ
Curr Opin Cell Biol. 2004 Jun; 16 (3): 223–9.PMID: 15145345

Recent advances have led to a more detailed understanding of RNA interference and its role in microRNA biogenesis and function. Primary microRNA transcripts are processed by the RNaseIII nuclease, Drosha, and are exported from the nucleus by Exportin-5. Dicer cleaves microRNAs into their mature forms, which can be incorporated into effector complexes that mediate gene silencing activities. The 3' two-nucleotide overhang structure, a signature of RNaseIII cleavage, has been identified as a critical specificity determinant in targeting and maintaining small RNAs in the RNA interference pathway. MicroRNA functional analyses and genetic and biochemical interrogation of components of the pathway are starting to provide a glimpse at the range of biological processes and phenomena regulated by RNA interference.

Associated Lotus transcripts 13

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .

Transcript Name Description GO terms GO count
Lj1g3v1387020.2
– PREDICTED: staphylococcal nuclease domain-containing protein 1-like [Glycine max] gi|356516458|ref|XP_003526911.1|
GO terms
2
Lj4g3v2861660.1
– PREDICTED: staphylococcal nuclease domain-containing protein 1-like [Glycine max] gi|356508886|ref|XP_003523184.1|
GO terms
2
LotjaGi1g1v0331200.1
– Nuclease domain-containing protein 1; TAIR: AT5G07350.1 TUDOR-SN protein 1; Swiss-Prot: sp|Q8VZG7|TSN1_ARATH Ribonuclease TUDOR 1; TrEMBL-Plants: tr|I1KBV2|I1KBV2_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0331200
GO terms
2
LotjaGi1g1v0331200.2
– Nuclease domain-containing protein 1; TAIR: AT5G07350.1 TUDOR-SN protein 1; Swiss-Prot: sp|Q8VZG7|TSN1_ARATH Ribonuclease TUDOR 1; TrEMBL-Plants: tr|I1KBV2|I1KBV2_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0331200
GO terms
2
LotjaGi1g1v0331400.1
– Nuclease domain-containing protein 1; TAIR: AT5G07350.1 TUDOR-SN protein 1; Swiss-Prot: sp|Q8VZG7|TSN1_ARATH Ribonuclease TUDOR 1; TrEMBL-Plants: tr|I1KBV2|I1KBV2_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0331400
GO terms
2
LotjaGi1g1v0331400.2
– Nuclease domain-containing protein 1; TAIR: AT5G07350.1 TUDOR-SN protein 1; Swiss-Prot: sp|Q8VZG7|TSN1_ARATH Ribonuclease TUDOR 1; TrEMBL-Plants: tr|I1KBV2|I1KBV2_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0331400
GO terms
2
LotjaGi1g1v0331400.3
– Nuclease domain-containing protein 1; TAIR: AT5G07350.1 TUDOR-SN protein 1; Swiss-Prot: sp|Q8VZG7|TSN1_ARATH Ribonuclease TUDOR 1; TrEMBL-Plants: tr|I1KBV2|I1KBV2_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0331400
GO terms
2
LotjaGi1g1v0331400.4
– Nuclease domain-containing protein 1; TAIR: AT5G07350.1 TUDOR-SN protein 1; Swiss-Prot: sp|Q8VZG7|TSN1_ARATH Ribonuclease TUDOR 1; TrEMBL-Plants: tr|I1KBV2|I1KBV2_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0331400
GO terms
2
LotjaGi1g1v0331400.5
– Nuclease domain-containing protein 1; TAIR: AT5G07350.1 TUDOR-SN protein 1; Swiss-Prot: sp|Q8VZG7|TSN1_ARATH Ribonuclease TUDOR 1; TrEMBL-Plants: tr|I1KBV2|I1KBV2_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0331400
GO terms
2
LotjaGi1g1v0331400.6
– Nuclease domain-containing protein 1; TAIR: AT5G07350.1 TUDOR-SN protein 1; Swiss-Prot: sp|Q8VZG7|TSN1_ARATH Ribonuclease TUDOR 1; TrEMBL-Plants: tr|I1KBV2|I1KBV2_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0331400
GO terms
2
LotjaGi1g1v0331400.7
– Nuclease domain-containing protein 1; TAIR: AT5G07350.1 TUDOR-SN protein 1; Swiss-Prot: sp|Q8VZG7|TSN1_ARATH Ribonuclease TUDOR 1; TrEMBL-Plants: tr|I1KBV2|I1KBV2_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0331400
GO terms
2
LotjaGi1g1v0331400.8
– Nuclease domain-containing protein 1; TAIR: AT5G07350.1 TUDOR-SN protein 1; Swiss-Prot: sp|Q8VZG7|TSN1_ARATH Ribonuclease TUDOR 1; TrEMBL-Plants: tr|I1KBV2|I1KBV2_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0331400
GO terms
2
LotjaGi4g1v0416800.1
– Nuclease domain-containing protein 1; TAIR: AT5G07350.1 TUDOR-SN protein 1; Swiss-Prot: sp|Q8VZG7|TSN1_ARATH Ribonuclease TUDOR 1; TrEMBL-Plants: tr|I1KP14|I1KP14_SOYBN Uncharacterized protein; Found in the gene: LotjaGi4g1v0416800
GO terms
2

Co-occuring GO terms 1

A list of co-occurring GO terms within the L. japonicus gene space:

GO term Namespace Name Observations Saturation (%)
GO:0031047
Biological process Gene silencing by RNA 1 7.69