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Field | Value |
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Namespace | Cellular component |
Short description | PcG protein complex |
Full defintion | A chromatin-associated multiprotein complex containing Polycomb Group proteins. In Drosophila, Polycomb group proteins are involved in the long-term maintenance of gene repression, and PcG protein complexes associate with Polycomb group response elements (PREs) in target genes to regulate higher-order chromatin structure. |
Subterm of |
The relationship of GO:0031519 with other GO terms.
Relationship type | GO terms |
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Is a | |
Regulates | n.a. |
Part of | n.a. |
Positively regulates | n.a. |
Negatively regulates | n.a. |
A force layout showing the ancestor tree for GO:0031519, and its immediate children. If you wish to explore the tree dynamically, please use the GO Explorer.
This table contains additional metadata associated with the GO entry's definition field.
Field | Value |
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PMID | The polycomb group protein complex of Drosophila melanogaster has different compositions at different target genes. Mol Cell Biol. 1997 Dec; 17 (12): 6773–83.PMID: 9372908 In Drosophila the Polycomb group genes are required for the long-term maintenance of the repressed state of many developmental regulatory genes. Their gene products are thought to function in a common multimeric complex that associates with Polycomb group response elements (PREs) in target genes and regulates higher-order chromatin structure. We show that the chromodomain of Polycomb is necessary for protein-protein interactions within a Polycomb-Polyhomeotic complex. In addition, Posterior Sex Combs protein coimmunoprecipitates Polycomb and Polyhomeotic, indicating that they are members of a common multimeric protein complex. Immunoprecipitation experiments using in vivo cross-linked chromatin indicate that these three Polycomb group proteins are associated with identical regulatory elements of the selector gene engrailed in tissue culture cells. Polycomb, Polyhomeotic, and Posterior Sex Combs are, however, differentially distributed on regulatory sequences of the engrailed-related gene invected. This suggests that there may be multiple different Polycomb group protein complexes which function at different target sites. Furthermore, Polyhomeotic and Posterior Sex Combs are also associated with expressed genes. Polyhomeotic and Posterior Sex Combs may participate in a more general transcriptional mechanism that causes modulated gene repression, whereas the inclusion of Polycomb protein in the complex at PREs leads to stable silencing. |
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
Transcript | Name | Description | GO terms | GO count |
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– | PREDICTED: histone-lysine N-methyltransferase CLF-like [Glycine max] gi|356540672|ref|XP_003538810.1| | 1 | ||
– | PREDICTED: histone-lysine N-methyltransferase CLF-like [Glycine max] gi|356540672|ref|XP_003538810.1| | 1 | ||
– | PREDICTED: histone-lysine N-methyltransferase EZA1-like [Glycine max] gi|356534774|ref|XP_003535927.1| | 1 | ||
– | PREDICTED: histone-lysine N-methyltransferase EZA1-like [Glycine max] gi|356534774|ref|XP_003535927.1| | 1 | ||
– | PREDICTED: histone-lysine N-methyltransferase EZA1-like [Glycine max] gi|356534774|ref|XP_003535927.1| | 1 | ||
– | PREDICTED: histone-lysine N-methyltransferase EZA1-like [Glycine max] gi|356534774|ref|XP_003535927.1| | 1 | ||
– | Histone-lysine N-methyltransferase; TAIR: AT4G02020.1 SET domain-containing protein; Swiss-Prot: sp|Q8S4P4|EZ3_MAIZE Histone-lysine N-methyltransferase EZ3; TrEMBL-Plants: tr|B9RNE0|B9RNE0_RICCO Histone-lysine N-methyltransferase; Found in the gene: LotjaGi2g1v0010500 | 1 | ||
– | Histone-lysine N-methyltransferase; TAIR: AT2G23380.1 SET domain-containing protein; Swiss-Prot: sp|P93831|CLF_ARATH Histone-lysine N-methyltransferase CLF; TrEMBL-Plants: tr|I1LHC7|I1LHC7_SOYBN Histone-lysine N-methyltransferase; Found in the gene: LotjaGi2g1v0403200 | 1 | ||
– | Histone-lysine N-methyltransferase; TAIR: AT4G02020.2 SET domain-containing protein; Swiss-Prot: sp|Q9ZSM8|EZA1_ARATH Histone-lysine N-methyltransferase EZA1; TrEMBL-Plants: tr|K7LGU3|K7LGU3_SOYBN Histone-lysine N-methyltransferase; Found in the gene: LotjaGi5g1v0244300 | 1 | ||
– | Histone-lysine N-methyltransferase; TAIR: AT4G02020.2 SET domain-containing protein; Swiss-Prot: sp|Q9ZSM8|EZA1_ARATH Histone-lysine N-methyltransferase EZA1; TrEMBL-Plants: tr|K7LGU2|K7LGU2_SOYBN Histone-lysine N-methyltransferase; Found in the gene: LotjaGi5g1v0244300 | 1 | ||
– | Histone-lysine N-methyltransferase; TAIR: AT4G02020.2 SET domain-containing protein; Swiss-Prot: sp|Q9ZSM8|EZA1_ARATH Histone-lysine N-methyltransferase EZA1; TrEMBL-Plants: tr|K7LGU3|K7LGU3_SOYBN Histone-lysine N-methyltransferase; Found in the gene: LotjaGi5g1v0244300 | 1 | ||
– | Histone-lysine N-methyltransferase; TAIR: AT4G02020.1 SET domain-containing protein; Swiss-Prot: sp|Q9ZSM8|EZA1_ARATH Histone-lysine N-methyltransferase EZA1; TrEMBL-Plants: tr|K7LGU3|K7LGU3_SOYBN Histone-lysine N-methyltransferase; Found in the gene: LotjaGi5g1v0244300 | 1 | ||
– | Histone-lysine N-methyltransferase; TAIR: AT4G02020.1 SET domain-containing protein; Swiss-Prot: sp|Q9ZSM8|EZA1_ARATH Histone-lysine N-methyltransferase EZA1; TrEMBL-Plants: tr|K7LGU2|K7LGU2_SOYBN Histone-lysine N-methyltransferase; Found in the gene: LotjaGi5g1v0244300 | 1 | ||
– | Histone-lysine N-methyltransferase; TAIR: AT4G02020.1 SET domain-containing protein; Swiss-Prot: sp|Q9ZSM8|EZA1_ARATH Histone-lysine N-methyltransferase EZA1; TrEMBL-Plants: tr|K7LGU2|K7LGU2_SOYBN Histone-lysine N-methyltransferase; Found in the gene: LotjaGi5g1v0244300 | 1 | ||
– | Histone-lysine N-methyltransferase; TAIR: AT4G02020.1 SET domain-containing protein; Swiss-Prot: sp|Q9ZSM8|EZA1_ARATH Histone-lysine N-methyltransferase EZA1; TrEMBL-Plants: tr|K7LGU2|K7LGU2_SOYBN Histone-lysine N-methyltransferase; Found in the gene: LotjaGi5g1v0244300 | 1 | ||
– | Histone-lysine N-methyltransferase; TAIR: AT4G02020.1 SET domain-containing protein; Swiss-Prot: sp|Q9ZSM8|EZA1_ARATH Histone-lysine N-methyltransferase EZA1; TrEMBL-Plants: tr|K7LGU3|K7LGU3_SOYBN Histone-lysine N-methyltransferase; Found in the gene: LotjaGi5g1v0244300 | 1 | ||
– | Histone-lysine N-methyltransferase; TAIR: AT4G02020.1 SET domain-containing protein; Swiss-Prot: sp|Q9ZSM8|EZA1_ARATH Histone-lysine N-methyltransferase EZA1; TrEMBL-Plants: tr|K7LGU2|K7LGU2_SOYBN Histone-lysine N-methyltransferase; Found in the gene: LotjaGi5g1v0244300 | 1 |
A list of co-occurring GO terms within the L. japonicus gene space:
GO term | Namespace | Name | Observations | Saturation (%) |
---|---|---|---|---|
Cellular component | PcG protein complex | 1 | 5.88 |