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GO:0035145

View this GO term in other databases

Overview

Field Value
Namespace Cellular component
Short description Exon-exon junction complex
Full defintion A multi-subunit complex deposited by the spliceosome upstream of messenger RNA exon-exon junctions. The exon-exon junction complex provides a binding platform for factors involved in mRNA export and nonsense-mediated mRNA decay.
Subterm of

Relationships

The relationship of GO:0035145 with other GO terms.

Relationship type GO terms
Is a
Regulates n.a.
Part of n.a.
Positively regulates n.a.
Negatively regulates n.a.

Ancestor tree

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Additional data

This table contains additional metadata associated with the GO entry's definition field.

Field Value
PMID
The protein Mago provides a link between splicing and mRNA localization.Le Hir H, Gatfield D, Braun IC, Forler D, Izaurralde E
EMBO Rep. 2001 Dec; 2 (12): 1119–24.PMID: 11743026

The proteins Mago and Y14 are evolutionarily conserved binding partners. Y14 is a component of the exon-exon junction complex (EJC), deposited by the spliceosome upstream of messenger RNA (mRNA) exon-exon junctions. The EJC is implicated in post-splicing events such as mRNA nuclear export and nonsense-mediated mRNA decay. Drosophila Mago is essential for the localization of oskar mRNA to the posterior pole of the oocyte, but the functional role of Mago in other species is unknown. We show that Mago is a bona fide component of the EJC. Like Y14, Mago escorts spliced mRNAs to the cytoplasm, providing a direct functional link between splicing and the downstream process of mRNA localization. Mago/Y14 heterodimers are essential in cultured Drosophila cells. Taken together, these results suggest that, in addition to its specialized function in mRNA localization, Mago plays an essential role in other steps of mRNA metabolism.

Associated Lotus transcripts 7

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .

Transcript Name Description GO terms GO count
Lj3g3v0577110.1
– PREDICTED: protein mago nashi homolog [Cicer arietinum] gi|502132054|ref|XP_004501210.1|
GO terms
2
Lj3g3v3712340.1
– PREDICTED: protein mago nashi homolog [Cicer arietinum] gi|502132054|ref|XP_004501210.1|
GO terms
2
Lj3g3v3714370.1
– PREDICTED: protein mago nashi homolog [Cicer arietinum] gi|502132054|ref|XP_004501210.1|
GO terms
2
LotjaGi3g1v0068100.1
– Protein mago nashi like; TAIR: AT1G02140.1 mago nashi family protein; Swiss-Prot: sp|O65806|MGN_EUPLA Protein mago nashi homolog; TrEMBL-Plants: tr|I3RZM3|I3RZM3_LOTJA Uncharacterized protein; Found in the gene: LotjaGi3g1v0068100
GO terms
2
LotjaGi3g1v0068100.2
– Protein mago nashi like; TAIR: AT1G02140.1 mago nashi family protein; Swiss-Prot: sp|O23676|MGN_ARATH Protein mago nashi homolog; TrEMBL-Plants: tr|I3RZM3|I3RZM3_LOTJA Uncharacterized protein; Found in the gene: LotjaGi3g1v0068100
GO terms
2
LotjaGi3g1v0068100.3
– Protein mago nashi like; TAIR: AT1G02140.1 mago nashi family protein; Swiss-Prot: sp|O23676|MGN_ARATH Protein mago nashi homolog; TrEMBL-Plants: tr|I1JMP2|I1JMP2_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0068100
GO terms
2
LotjaGi3g1v0551700.1
– Protein mago nashi like; TAIR: AT1G02140.1 mago nashi family protein; Swiss-Prot: sp|O65806|MGN_EUPLA Protein mago nashi homolog; TrEMBL-Plants: tr|I3T8H3|I3T8H3_LOTJA Uncharacterized protein; Found in the gene: LotjaGi3g1v0551700
GO terms
2

Co-occuring GO terms 1

A list of co-occurring GO terms within the L. japonicus gene space:

GO term Namespace Name Observations Saturation (%)
GO:0035145
Cellular component Exon-exon junction complex 1 14.29