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GO:0043564

View this GO term in other databases

Overview

Field Value
Namespace Cellular component
Short description Ku70:Ku80 complex
Full defintion Heterodimeric protein complex composed of a 70 kDa and a 80 kDa subunit, binds DNA through a channel formed by the heterodimer. Functions in DNA double stranded break repair, chromosome maintenance, transcription regulation, V(D)J recombination, and activation of DNA-PK.
Subterm of

Relationships

The relationship of GO:0043564 with other GO terms.

Relationship type GO terms
Is a
Regulates n.a.
Part of n.a.
Positively regulates n.a.
Negatively regulates n.a.

Ancestor tree

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Additional data

This table contains additional metadata associated with the GO entry's definition field.

Field Value
PMID
Dimerization, translocation and localization of Ku70 and Ku80 proteins.Koike M
J Radiat Res. 2002 Sep; 43 (3): 223–36.PMID: 12518983

The Ku protein is a complex of two subunits, Ku70 and Ku80, and was originally identified as an autoantigen recognized by the sera of patients with autoimmune diseases. The Ku protein plays a key role in multiple nuclear processes, e.g., DNA repair, chromosome maintenance, transcription regulation, and V(D)J recombination. The mechanism underlying the regulation of all the diverse functions of Ku is still unclear, although it seems that Ku is a multifunctional protein that works in nuclei. On the other hand, several studies have reported cytoplasmic or cell surface localization of Ku in various cell types. To clarify the fundamental characteristics of Ku, we have examined the expression, heterodimerization, subcellular localization, chromosome location, and molecular mechanisms of the nuclear transport of Ku70 and Ku80. The mechanism that regulates for nuclear localization of Ku70 and Ku80 appears to play, at least in part, a key role in regulating the physiological function of Ku in vivo.

Associated Lotus transcripts 5

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .

Transcript Name Description GO terms GO count
Lj3g3v2735120.1
– PREDICTED: ATP-dependent DNA helicase 2 subunit KU80-like isoform X1 [Cicer arietinum] gi|502146520|ref|XP_004506489.1|
GO terms
8
Lj5g3v2302940.1
– PREDICTED: ATP-dependent DNA helicase 2 subunit KU70-like [Glycine max] gi|356576925|ref|XP_003556580.1|
GO terms
7
LotjaGi3g1v0433200.1
– ATP-dependent DNA helicase 2 subunit KU80; TAIR: AT1G48050.1 Ku80 family protein; Swiss-Prot: sp|Q9FQ09|KU80_ARATH ATP-dependent DNA helicase 2 subunit KU80; TrEMBL-Plants: tr|G7JDE1|G7JDE1_MEDTR ATP-dependent DNA helicase 2 subunit KU80; Found in the gene: LotjaGi3g1v0433200
GO terms
8
LotjaGi3g1v0433200.2
– ATP-dependent DNA helicase 2 subunit KU80; TAIR: AT1G48050.1 Ku80 family protein; Swiss-Prot: sp|Q9FQ09|KU80_ARATH ATP-dependent DNA helicase 2 subunit KU80; TrEMBL-Plants: tr|G7JDE1|G7JDE1_MEDTR ATP-dependent DNA helicase 2 subunit KU80; Found in the gene: LotjaGi3g1v0433200
GO terms
8
LotjaGi5g1v0365500.1
– ATP-dependent DNA helicase 2 subunit Ku70; TAIR: AT1G16970.1 ATP-dependent DNA helicase 2 subunit Ku70-like protein; Swiss-Prot: sp|Q9FQ08|KU70_ARATH ATP-dependent DNA helicase 2 subunit KU70; TrEMBL-Plants: tr|K7N5J8|K7N5J8_SOYBN Uncharacterized protein; Found in the gene: LotjaGi5g1v0365500
GO terms
7

Co-occuring GO terms 1

A list of co-occurring GO terms within the L. japonicus gene space:

GO term Namespace Name Observations Saturation (%)
GO:0043564
Cellular component Ku70:Ku80 complex 1 20.00