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GO:0071985

View this GO term in other databases

Overview

Field Value
Namespace Biological process
Short description Multivesicular body sorting pathway
Full defintion A vesicle-mediated transport process in which transmembrane proteins are ubiquitylated to facilitate their entry into luminal vesicles of multivesicular bodies (MVBs); upon subsequent fusion of MVBs with lysosomes or vacuoles, the cargo proteins are degraded.
Subterm of

Relationships

The relationship of GO:0071985 with other GO terms.

Relationship type GO terms
Is a
Regulates n.a.
Part of n.a.
Positively regulates n.a.
Negatively regulates n.a.

Ancestor tree

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Additional data

This table contains additional metadata associated with the GO entry's definition field.

Field Value
GOCmah
PMID
A concentric circle model of multivesicular body cargo sorting.Nickerson DP, Russell MR, Odorizzi G
EMBO Rep. 2007 Jul; 8 (7): 644–50.PMID: 17603537

Targeting of ubiquitylated transmembrane proteins into luminal vesicles of endosomal multivesicular bodies (MVBs) depends on their recognition by endosomal sorting complexes required for transport (ESCRTs), which are also required for MVB vesicle formation. The model originally proposed for how ESCRTs function succinctly summarizes much of the protein-protein interaction and genetic data but oversimplifies the coordination of cargo recognition and cannot explain why ESCRTs are required for the budding of MVB vesicles. Recent structural and functional studies of ESCRT complexes suggest an alternative model that might direct the next series of breakthroughs in understanding protein sorting through the MVB pathway.

Associated Lotus transcripts 5

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .

Transcript Name Description GO terms GO count
Lj2g3v1510860.1
– Vacuolar protein sorting-associated protein [Medicago truncatula] gi|357484837|ref|XP_003612706.1|
GO terms
2
Lj2g3v1510860.2
– Vacuolar protein sorting-associated protein [Medicago truncatula] gi|357484837|ref|XP_003612706.1|
GO terms
2
Lj6g3v0920170.1
– Vacuolar protein sorting-associated protein-like protein [Medicago truncatula] gi|357459547|ref|XP_003600054.1|
GO terms
2
LotjaGi2g1v0338500.1
– Vacuolar protein sorting-associated protein 25; TAIR: AT4G19003.1 E2F/DP family winged-helix DNA-binding domain-containing protein; Swiss-Prot: sp|Q8VZC9|VPS25_ARATH Vacuolar protein sorting-associated protein 25; TrEMBL-Plants: tr|I3SXY8|I3SXY8_LOTJA Uncharacterized protein; Found in the gene: LotjaGi2g1v0338500
GO terms
2
LotjaGi6g1v0166400.1
– Vacuolar protein sorting-associated protein; TAIR: AT4G27040.1 EAP30/Vps36 family protein; Swiss-Prot: sp|Q5M759|VP221_ARATH Vacuolar protein sorting-associated protein 22 homolog 1; TrEMBL-Plants: tr|G7IXK4|G7IXK4_MEDTR Vacuolar protein sorting-associated protein; Found in the gene: LotjaGi6g1v0166400
GO terms
2

Co-occuring GO terms 1

A list of co-occurring GO terms within the L. japonicus gene space:

GO term Namespace Name Observations Saturation (%)
GO:0071985
Biological process Multivesicular body sorting pathway 1 20.00