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IPR000385 is a MoaA/NifB/PqqE, iron-sulphur binding, conserved site.
<p>A number of proteins involved in the biosynthesis of metallo cofactors have been shown [[cite:PUB00000168], [cite:PUB00002946]] to be evolutionary related. These include:</p> <ul> <li>Bacterial and archebacterial protein moaA, which is involved in the biosynthesis of the molybdenum cofactor (molybdopterin; MPT).</li> <li>Arabidopsis thaliana (Mouse-ear cress) cnx2, a protein involved in molybdopterin biosynthesis and which is highly similar to moaA.</li> <li>Bacillus subtilis narA, which seems to be the moaA ortholog in that bacteria.</li> <li>Bacterial protein nifB (or fixZ) which is involved in the biosynthesis of the nitrogenase iron-molybdenum cofactor.</li> <li>Bacterial protein pqqE which is involved in the biosynthesis of the cofactor pyrrolo-quinoline-quinone (PQQ).</li> <li>Pyrococcus furiosus cmo, a protein involved in the synthesis of a molybdopterin-based tungsten cofactor.</li> <li>Caenorhabditis elegans hypothetical protein F49E2.1.</li> </ul> <p>These proteins share, in their N-terminal region, a conserved domain that contains three cysteines. In moaA, these cysteines have been shown to be important for biological activity by binding a [4Fe-4S] cluster [[cite:PUB00015124]]. The three cysteines each coordinate one Fe, while S-adenosylmethionine is the fourth ligand to the cluster and binds to its unique Fe as an N/O chelate.</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | Catalytic activity | Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. | ||
| Molecular function | Metal ion binding | Interacting selectively and non-covalently with any metal ion. | ||
| Molecular function | 4 iron, 4 sulfur cluster binding | Interacting selectively and non-covalently with a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: molybdopterin biosynthesis protein CNX2-like [Glycine max] gi|356525689|ref|XP_003531456.1| | 16 | ||
| – | GTP 3',8-cyclase; TAIR: AT2G31955.1 cofactor of nitrate reductase and xanthine dehydrogenase 2; Swiss-Prot: sp|Q39055|CNX2_ARATH GTP 3',8-cyclase, mitochondrial; TrEMBL-Plants: tr|I1KTQ5|I1KTQ5_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0127600 | 21 | ||
| – | GTP 3',8-cyclase; TAIR: AT2G31955.3 cofactor of nitrate reductase and xanthine dehydrogenase 2; Swiss-Prot: sp|Q39055|CNX2_ARATH GTP 3',8-cyclase, mitochondrial; TrEMBL-Plants: tr|I1KTQ5|I1KTQ5_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0127600 | 15 | ||
| – | GTP 3',8-cyclase; TAIR: AT2G31955.3 cofactor of nitrate reductase and xanthine dehydrogenase 2; Swiss-Prot: sp|Q39055|CNX2_ARATH GTP 3',8-cyclase, mitochondrial; TrEMBL-Plants: tr|D7MW86|D7MW86_ARALL Putative uncharacterized protein; Found in the gene: LotjaGi3g1v0127600 | 15 | ||
| – | GTP 3',8-cyclase; TAIR: AT2G31955.1 cofactor of nitrate reductase and xanthine dehydrogenase 2; Swiss-Prot: sp|Q39055|CNX2_ARATH GTP 3',8-cyclase, mitochondrial; TrEMBL-Plants: tr|I1KTQ5|I1KTQ5_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0127600 | 21 | ||
| – | GTP 3',8-cyclase; TAIR: AT2G31955.1 cofactor of nitrate reductase and xanthine dehydrogenase 2; Swiss-Prot: sp|Q39055|CNX2_ARATH GTP 3',8-cyclase, mitochondrial; TrEMBL-Plants: tr|I1KTQ5|I1KTQ5_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0127600 | 21 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| cd05644 | CDD | 1 | 16.67 |