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IPR013483 is a Molybdenum cofactor biosynthesis protein A.
<p>This entry represents the MoaA protein (molybdenum cofactor biosynthesis protein A), also known as cyclic pyranopterin monophosphate synthase or GTP 3',8-cyclase.</p> <p>MoaA is a member of the wider S-adenosylmethionine(SAM)-dependent enzyme family which catalyze the formation of protein and/or substrate radicals by reductive cleavage of SAM via a [4Fe-4S] cluster. Monomeric and homodimeric forms of MoaA have been observed <i>in vivo</i>, and it is not clear what the physiologically relevant form of the enzyme is [[cite:PUB00015124]]. The core of each monomer consists of an incomplete TIM barrel, formed by the N-terminal region of the protein, containing a [4Fe-4S] cluster. The C-terminal region of the protein, which also contains a [4Fe-4S] cluster consists of a β-sheet covering the lateral opening of the barrel, an extended loop and three α-helices. The N-terminal [4Fe-4S] cluster is coordinated with 3 cysteines and an exchangeable SAM molecule, while the C-terminal [4Fe-4S], also coordinated with 3 cysteines, is the binding and activation site for GTP [[cite:PUB00036007]].</p> <p>The majority of molybdenum-containing enzymes utilise a molybdenum cofactor (MoCF or Moco) consisting of a Mo atom coordinated via a cis-dithiolene moiety to molybdopterin (MPT). MoCF is ubiquitous in nature, and the pathway for MoCF biosynthesis is conserved in all three domains of life. MoCF-containing enzymes function as oxidoreductases in carbon, nitrogen, and sulphur metabolism [[cite:PUB00034759], [cite:PUB00034757]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Biological process | Mo-molybdopterin cofactor biosynthetic process | The chemical reactions and pathways resulting in the formation of the Mo-molybdopterin cofactor, essential for the catalytic activity of some enzymes. The cofactor consists of a mononuclear molybdenum (Mo) ion coordinated by one or two molybdopterin ligands. | ||
| Molecular function | Metal ion binding | Interacting selectively and non-covalently with any metal ion. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | GTP 3',8-cyclase; TAIR: AT2G31955.1 cofactor of nitrate reductase and xanthine dehydrogenase 2; Swiss-Prot: sp|Q39055|CNX2_ARATH GTP 3',8-cyclase, mitochondrial; TrEMBL-Plants: tr|I1KTQ5|I1KTQ5_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0127600 | 21 | ||
| – | GTP 3',8-cyclase; TAIR: AT2G31955.1 cofactor of nitrate reductase and xanthine dehydrogenase 2; Swiss-Prot: sp|Q39055|CNX2_ARATH GTP 3',8-cyclase, mitochondrial; TrEMBL-Plants: tr|I1KTQ5|I1KTQ5_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0127600 | 21 | ||
| – | GTP 3',8-cyclase; TAIR: AT2G31955.1 cofactor of nitrate reductase and xanthine dehydrogenase 2; Swiss-Prot: sp|Q39055|CNX2_ARATH GTP 3',8-cyclase, mitochondrial; TrEMBL-Plants: tr|I1KTQ5|I1KTQ5_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0127600 | 21 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| cd05644 | CDD | 1 | 33.33 |