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IPR010505 is a Molybdenum cofactor biosynthesis protein A-like, twitch domain.
<p>This entry represents the iron-sulfur cluster-binding twitch domain of GTP 3',8-cyclase, which is also known as molybdenum cofactor biosynthesis protein A (MoaA) in bacteria and archaea, molybdenum cofactor biosynthesis protein 1 (MOCS1) in most eukaryotes, and molybdenum cofactor biosynthesis enzyme CNX2 in plants [[cite:PUB00083471]]. They belong to a family of enzymes involved in the synthesis of metallo-cofactors ([interpro:IPR000385]). Each subunit of the MoaA dimer is comprised of an N-terminal SAM domain ([interpro:IPR007197]) that contains the [4Fe-4S] cluster typical for this family of enzymes, as well as an additional [4Fe-4S] cluster in the C-terminal domain that is unique to MoaA proteins, involved in substrate binding [[cite:PUB00015124]]. The unique Fe site of the C-terminal [4Fe-4S] cluster is thought to be involved in the binding and activation of 5'-GTP [[cite:PUB00036007]].</p> <p>Mutations in the human MoCF biosynthesis proteins MOCS1, MOCS2 or GEPH cause MoCF Deficiency type A (MOCOD), causing the loss of activity of MoCF-containing enzymes, resulting in neurological abnormalities and death [[cite:PUB00015126]].</p> <p>The majority of molybdenum-containing enzymes utilise a molybdenum cofactor (MoCF or Moco) consisting of a Mo atom coordinated via a cis-dithiolene moiety to molybdopterin (MPT). MoCF is ubiquitous in nature, and the pathway for MoCF biosynthesis is conserved in all three domains of life. MoCF-containing enzymes function as oxidoreductases in carbon, nitrogen, and sulphur metabolism [[cite:PUB00034759], [cite:PUB00034757]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Biological process | Mo-molybdopterin cofactor biosynthetic process | The chemical reactions and pathways resulting in the formation of the Mo-molybdopterin cofactor, essential for the catalytic activity of some enzymes. The cofactor consists of a mononuclear molybdenum (Mo) ion coordinated by one or two molybdopterin ligands. | ||
| Cellular component | Molybdopterin synthase complex | A protein complex that possesses molybdopterin synthase activity. In E. coli, the complex is a heterotetramer consisting of two MoaD and two MoaE subunits. | ||
| Molecular function | 4 iron, 4 sulfur cluster binding | Interacting selectively and non-covalently with a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: molybdopterin biosynthesis protein CNX2-like [Glycine max] gi|356525689|ref|XP_003531456.1| | 9 | ||
| – | GTP 3',8-cyclase; TAIR: AT2G31955.1 cofactor of nitrate reductase and xanthine dehydrogenase 2; Swiss-Prot: sp|Q39055|CNX2_ARATH GTP 3',8-cyclase, mitochondrial; TrEMBL-Plants: tr|I1KTQ5|I1KTQ5_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0127600 | 21 | ||
| – | GTP 3',8-cyclase; TAIR: AT2G31955.1 cofactor of nitrate reductase and xanthine dehydrogenase 2; Swiss-Prot: sp|Q39055|CNX2_ARATH GTP 3',8-cyclase, mitochondrial; TrEMBL-Plants: tr|I1KTQ5|I1KTQ5_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0127600 | 21 | ||
| – | GTP 3',8-cyclase; TAIR: AT2G31955.1 cofactor of nitrate reductase and xanthine dehydrogenase 2; Swiss-Prot: sp|Q39055|CNX2_ARATH GTP 3',8-cyclase, mitochondrial; TrEMBL-Plants: tr|I1KTQ5|I1KTQ5_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0127600 | 21 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| cd05644 | CDD | 1 | 25.00 |