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IPR000406 is a Rho protein GDP-dissociation inhibitor.
<p>The GDP dissociation inhibitor for rho proteins, rho GDI, regulates GDP/GTP exchange by inhibiting the dissociation of GDP from them. The protein contains 204 amino acids, with a calculated Mr value of 23,421. Hydropathy analysis shows it to be largely hydrophilic, with a single hydrophobic region. The protein plays an important role in the activation of the superoxide (O2-)-generating NADPH oxidase of phagocytes. This process requires the interaction of membrane-associated cytochrome b559 with 3 cytosolic components: p47-phox, p67-phox and a heterodimer of the small G-protein p21rac1 and rho GDI [[cite:PUB00001445]]. The association of p21rac and GDI inhibits dissociation of GDP from p21rac, thereby maintaining it in an inactive form. The proteins are attached via a lipid tail on p21rac that binds to the hydrophobic region of GDI [[cite:PUB00003781]]. Dissociation of these proteins might be mediated by the release of lipids (e.g., arachidonate and phosphatidate) from membranes through the action of phospholipases [[cite:PUB00003781]]. The lipids may then compete with the lipid tail on p21rac for the hydrophobic pocket on GDI.</p> <p>Two homologues of rho GDP-dissociation inhibitors have been identified in Dicytostelium: GDI1 and GDI2. They are cytosolic proteins. GDI1 has been found to play a central role in cytokinesis through the regulation of Rho family GTPases Rac1s and/or RacE [[cite:PUB00101427], [cite:PUB00101430]].</p> <p>Rho GDI in yeast has been shown to have similar properties as mammalian rho GDI [[cite:PUB00101429]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | Rho GDP-dissociation inhibitor activity | Prevents the dissociation of GDP from the small GTPase Rho, thereby preventing GTP from binding. | ||
| Cellular component | Cytoplasm | All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: rho GDP-dissociation inhibitor 1-like [Cicer arietinum] gi|502110137|ref|XP_004493808.1| | 9 | ||
| – | PREDICTED: rho GDP-dissociation inhibitor 1-like [Glycine max] gi|356520100|ref|XP_003528703.1| | 8 | ||
| – | PREDICTED: rho GDP-dissociation inhibitor 1-like [Glycine max] gi|356520100|ref|XP_003528703.1| | 9 | ||
| – | PREDICTED: rho GDP-dissociation inhibitor 1-like [Glycine max] gi|356512404|ref|XP_003524909.1| | 10 | ||
| – | PREDICTED: rho GDP-dissociation inhibitor 1-like [Glycine max] gi|356555726|ref|XP_003546181.1| | 10 | ||
| – | Rho GDP-dissociation inhibitor 1; TAIR: AT3G07880.1 Immunoglobulin E-set superfamily protein; Swiss-Prot: sp|Q9SFC6|GDIR_ARATH Rho GDP-dissociation inhibitor 1; TrEMBL-Plants: tr|A0A0R0GGY5|A0A0R0GGY5_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0006000 | 10 | ||
| – | Rho GDP-dissociation inhibitor 1; TAIR: AT1G62450.1 Immunoglobulin E-set superfamily protein; Swiss-Prot: sp|Q9SFC6|GDIR_ARATH Rho GDP-dissociation inhibitor 1; TrEMBL-Plants: tr|I3SF08|I3SF08_LOTJA Uncharacterized protein; Found in the gene: LotjaGi1g1v0706400 | 9 | ||
| – | Rho GDP-dissociation inhibitor 1; TAIR: AT3G07880.1 Immunoglobulin E-set superfamily protein; Swiss-Prot: sp|Q9SFC6|GDIR_ARATH Rho GDP-dissociation inhibitor 1; TrEMBL-Plants: tr|I3SQG8|I3SQG8_LOTJA Uncharacterized protein; Found in the gene: LotjaGi4g1v0008700 | 10 | ||
| – | Rho GDP-dissociation inhibitor 1; TAIR: AT3G07880.1 Immunoglobulin E-set superfamily protein; Swiss-Prot: sp|Q9SFC6|GDIR_ARATH Rho GDP-dissociation inhibitor 1; TrEMBL-Plants: tr|I1K3P3|I1K3P3_SOYBN Uncharacterized protein; Found in the gene: LotjaGi4g1v0367800 | 10 | ||
| – | Rho GDP-dissociation inhibitor 1; TAIR: AT3G07880.1 Immunoglobulin E-set superfamily protein; Swiss-Prot: sp|Q9SFC6|GDIR_ARATH Rho GDP-dissociation inhibitor 1; TrEMBL-Plants: tr|A0A1J7H6P8|A0A1J7H6P8_LUPAN Uncharacterized protein; Found in the gene: LotjaGi6g1v0286900 | 10 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| mobidb-lite | MobiDBLite | 1 | 10.00 |