Your browser is unable to support new features implemented in HTML5 and CSS3 to render this site as intended. Your experience may suffer from functionality degradation but the site should remain usable. We strongly recommend the latest version of Google Chrome, OS X Safari or Mozilla Firefox. As Safari is bundled with OS X, if you are unable to upgrade to a newer version of OS X, we recommend using an open source browser. Dismiss message
IPR000445 is a Helix-hairpin-helix motif.
<p>The HhH motif is a stretch of approximately 20 amino acids that is present in prokaryotic and eukaryotic non-sequence-specific DNA binding proteins [[cite:PUB00006161], [cite:PUB00006160], [cite:PUB00006162]]. The HhH motif is similar to, but distinct from, the HtH motif. Both of these motifs have two helices connected by a short turn. In the HtH motif the second helix binds to DNA with the helix in the major groove. This allows the contact between specific base and residues throughout the protein. In the HhH motif the second helix does not protrude from the surface of the protein and therefore cannot lie in the major groove of the DNA. Crystallographic studies suggest that the interaction of the HhH domain with DNA is mediated by amino acids located in the strongly conserved loop (L-P-G-V) and at the N-terminal end of the second helix [[cite:PUB00006161]]. This interaction could involve the formation of hydrogen bonds between protein backbone nitrogens and DNA phosphate groups [[cite:PUB00004467]]. The structural difference between the HtH and HhH domains is reflected at the functional level: whereas the HtH domain, found primarily in gene regulatory proteins and binds DNA in a sequence specific manner, the HhH domain is rather found in proteins involved in enzymatic activities and binds DNA with no sequence specificity [[cite:PUB00004467]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | DNA binding | Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: kinesin-like protein KIF22-like [Glycine max] gi|356523149|ref|XP_003530204.1| | 19 | ||
| – | PREDICTED: endonuclease III-like protein 1-like [Cicer arietinum] gi|502148937|ref|XP_004507328.1| | 23 | ||
| – | Kinesin-like protein; TAIR: AT5G02370.1 ATP binding microtubule motor family protein; Swiss-Prot: sp|Q5E913|KN10B_ARATH Kinesin-like protein KIN-10B; TrEMBL-Plants: tr|K7L1G4|K7L1G4_SOYBN Kinesin-like protein; Found in the gene: LotjaGi1g1v0580700 | 20 | ||
| – | Endonuclease III homolog; TAIR: AT2G31450.2 DNA glycosylase superfamily protein; Swiss-Prot: sp|Q9SIC4|NTH1_ARATH Endonuclease III homolog 1, chloroplastic; TrEMBL-Plants: tr|A0A0L9V790|A0A0L9V790_PHAAN Endonuclease III homolog; Found in the gene: LotjaGi3g1v0497800 | 21 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| mobidb-lite | MobiDBLite | 1 | 25.00 |