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| Field | Value |
|---|---|
| Gene ID | LotjaGi3g1v0497800 |
| Transcript ID | LotjaGi3g1v0497800.1 |
| Lotus japonicus genome version | Gifu v1.2 |
| Description | Endonuclease III homolog; TAIR: AT2G31450.2 DNA glycosylase superfamily protein; Swiss-Prot: sp|Q9SIC4|NTH1_ARATH Endonuclease III homolog 1, chloroplastic; TrEMBL-Plants: tr|A0A0L9V790|A0A0L9V790_PHAAN Endonuclease III homolog; Found in the gene: LotjaGi3g1v0497800 |
| Working Lj name | n.a. |
Genomic sequence (LjG1.1_chr3:91646305..91651603) extracted from Lotus japonicus Gifu genome v1.2.
ACAATCTATAGTTTCAAAACCAAATGTTGGTCGTTTCCGCTCCTCCTCCCTTGTCTGGTTTGAGGAGAATCCAAGCTTTG ATCATGTCTGAGACACCACGACGATCTTACAAAGCTTCTCTCAGCAATACCAACACACCCACCTCGCTTGTTGAAGGCTC TGATTCCTCCAACGCCGCTTCTTCAGTGTCCCAACTTCGTGTCTTTGTGAGAAAAAACAAGAGACCCAGAAAAATGACTA TGGAACTTCAACAAAAGGAGCCTCCTCCACCAACCCAGGACCATAAAGTAAGCACGTTTTCATCATTGATTGCTTGTTTT GGCATAAATTGATCAATGGGGTGATGGGTGTCTTTATGAATAAAAGTTCCATGAAATGCATAAAACTTTTTCTTCATATC AAATTTATTATTCCCTAGTTTCCCATTTTCGTGCTGTTATGATAAAGTTTCTGACTTGCAATGTGGGTATTTTTAGTTTT TTAATGTGATTTGCAATGAAGAAACTTATCATATATTAGTTTCTGTGTATGCAGAAGCTTGGTCCACCTGAAATTGAAGA CTTTGCATACAGTGGAGCAAATGTGGCTGAGTGCAGTAAGTAGCACCTCTTTCCTTAAGTTTGCAGTGCTGGTATTACCT ATTTGGTTATTTCCCACCTTGAACCATTTATATAAGATGTATTCTTGTATATGCTTGCATATTTAAATTCACTATAACTG GCATGGTCCCTCCCCAGGGGTTTAATGAAGTGTTACAGAAATTACTATAGTTATTTCCAGGTGATTAATCCTATCTATGG TAAATATATGAAGCAGAAATAAAAAAGGAATAGGTAAAGACTAAAGAGTAATGATTTTGGAAGGGTGCAATAAATTAACA TTAGTCAATGCTGATACTTGTTTCATTAGTTGGTTTGGAGTAGCTTGTAAGTAATTAAGAAATATTAATGTTCTTCTGCC TCCTAATGGAGATTGGAGAAGGTAACTGCTGGCTATTGTGTATTGGTCTTGCTTGCCCAATCAGGAGTAGCAGTATGTGT GCATGTGTCAGAGACACTCACTGCACATATCAGTCATTTTCATCTTCTCTTATTCTGATTATAGGACTCAGTTCTTATAG AAATAGCTTTCCTTTTTCCAGGAAAAACAGAATCGGTCTCAGATGTGGTCCTAGCAGAAGTTGCTTCTCCAACACCCAGC GGTAAGAACTAATAAGTGATACAGTATGTAGTTGCAAAATGCTATTGTTTTAGGTGTTTTAATTATTTTTCCAAATGTTT CTCCTCTTTTGGTATTGCAAAATGCTTTGAAAATCATTAGATCAGGAAACCTAGGTAACAATTAATGTAGCCAAGCAGGC TCTCACTCAGTAATTTAACAATGCTTGCTCTTTATAACTCATTTGTTGGATTAAAATATGTGTACTTACTGCTTAGTGAA CACGGTCAATTAAAAATAGGATTTCGCTGACCTTCGCAATTTTTGTCCCGCCATATTGCATCTAGTGTACGCACCCAAGT ACAAAATGTTTGTGTGTTGGTCAAAAACCATGCCTTTTCTCGGAAATGTATTTAATGAATTGTATTTTATTCAATTTGTC ACATTAACCATGTACATAATGATTCAATCATCTTGTCACCATATTATTCATTTGAAACTGATAGTCTAATATACTTCCAG TTCCATCTATTTTGTCTGATAGCATGGCCCCACCTTTAGTCTAGGAAGCTTAAATTATTTAGTTCATGTATGATATAGGT GAATTACCTGCTCACTGGGAAAAGGTGCTTGAGGGGATTCGCAAAATGAGGTGTTCTGCAGAAGCACCGGTAGACACTAT GGGATGTGAGAAAGCTGGAAATACTCTACCTCCTAAGGTCTGACTCTGTATATACTGCTGTCATTTTGATCTAAAGGGGT AAAGAGAAGCATTTATTTGTTGGTTTCTGTCTTGGTTAATTTAAGAAAAAGTGGTTATGAAATATTTGAATATTGAATAG AATTTGGCTCATCACACAACCTTTTGTAACAGAACAATGACAGCAGGAACACTGTTGATTTGATAAACCGATAGCCATTC ATCTACCAATGCAGCTGTTACTTTTTCAATTAGTTGATAATAATAAATTAACAATTGAACTAAACCATTCAACCCCTTGT GTGCAATCTTGTATCGAATTGAATGGTTGGCTTGTCACAGGGTTTTTTATCGTTCATTTTATATAACTATTCTTTATGAA TTGTTATGACTTATGATCATGGGAGCATTGTAGTTCTTTTAACTTCTATATATTGTAGAAGCACAATATGAATGAATTTA CCCTTATCTAAATTCTTATGTGTATGATTAGGAAAGAAGATTCGCTGTCCTGGTATCTTCTCTTTTATCAAGTCAAACCA AGGATCATGTTAATCATGGTGAGTACATATGCCTTATGAAGTTTATAGTAAAGATGATTGTTGTCAAGTTTCCTGGCTTT TGTGCACAGAGATGCATTCTGAAATAATATTATAGTAGTGCTGTTTTGTTGATTTGGTCAAATGCCCTGAGGCACACAAG CTTCATTGAAGTATGAGATTAGCAGCTTTAATCTTCAATAAGAAAATGTATATTATCTCAGAGCACCAGAGGCAGAATTT ATCTCATATTTACTTATTGACATGGCGAGTGAAGAGAAACTGAAAACATTGGTTGTCATGTGATATGAGATTATGTGTCT AGATAGTGATGATTTATTGTGGCTTGTCTTGTTTTGAATTGAGGGAGTTTTGGATTTGGGCAAATAATACTGAAAGTCTG AAACATGATAAGATAATATGCCAGTGTTTTAAGTTCTGAACCTTGGAAAATTGGTAGGTTTGCCACTGTGTTAAAACCCA TCCACTAAGCTGTTGAAAGTGGGATTGTGATTCATCTGCAGAGAATGCTTTTCCACAGCTAAAGTAATTTAAATAAATGT AAACAGATAATTTATTGTGATGGTAGAAAGGTGTTGCCCACCACTTTAAAGAGAGCAAACATGTATTCTTATGAAACGTG ATATAACTCGAAGAAATGGTAGAAGGAAAAAGGAGGAAACATAAGAAAAAATAGATAGTTTCTGTGGTTCTTGATATAAA TGAGATTTGACAAAAAATTATGCAGCCATTGTACTTTCGGCCCCAAGGTGTTGTTTACTTTGGTCTTGGTGTATGTGATT TATACTTGGGGTTGTTGCTGAATTATGTTTGTAATATTTCAACTTATGAAAAGGTTCTAGTTCAACTTACAAGTTTTTTG TTAAGAATAGGAGCAATCCAACGTCTACTTCAAAATGATTTGCTTACGGCTGATGCAATCAACAATGCTGATGAAGAAAC CATCAAAAAGTTGATTTACCCTGTATGTCCCTTGTTTCTTTTATAGATACTGCCTCTCGTGTTATTCAAGTAATTTAGAT TTAGTGGCAAGTTAAGGAAATATACTTATGAAACTACCGGTAATTCCTTAACTTGTTTGTCATCGTGTCAATTTCTTTTA GTGTTATGTTTGTTTTGTAATATATTAATTGAATCTGTGCTTGTACCTTTGGATATTCTTTTTTTTCCAGGTTGGGTTTT ATACAAGAAAAGCTACTAACTTGAAAAAAATTGCAAATATTTGTCTCATGAAGTATGACGGAGACATACCTAACTCACTT GAGCAACTACTTTTACTTCCAGGCATAGGTCCTAAGATGGCACATTTGGTATGCATAATGGCTTTTCTAATTCAAACCAT ATGTTGCATTAGTTTTCTAAACTTCATTTTGTCACTGGCACTGTAGGTTATGAATGTTGGATGGAACAATGTCCAAGGCA TATGTGTAGATACTCATGTCCACCGCATTTGCAATAGGCTTGGGTGGGTGTCAAGATTGGGCACAAAACAGGTACGTTGG TGCTGTTGCAGATATGATAGTTAGGTGGCATTCGTTCATGTATGGTCATTATGTCCTAATTTATTTGTTGCCTCAACATC TTGGTGCTGTTGCAGATATGATAGTCGTGATGATAGTTTGTAATGCACAGTACTTTACTTGTTTTCTATTGTTATTACAT TTTGTTTTTGGTATACTTTATCGTTAATCTGCAACCAATATTCATTCATATGTTCAATAAGCTACCATATCACTCTTATA GATCATATGAAATTCTTCAACGGTAGTTAGCAAAATCAAACCAGCTCTTTCAAGACTTGGGTTTAGCTTGTTCTATTACT GTGCTTCTAATTGTGACACTTGAATATTACTAATCCTTTTCAATTTGGCAGAAAACTTTGACACCTGAACAGACACGAGA GGCACTGCAAAGGTGGCTTCCAAGGGAAGAATGGGATCCCATAAATCCTCTATTGGTATTTCCAACTCTGTCCAAATCAT ACTTGAACAATTTTACTGTCATGTTTTGCTATAAACGCTTTGCTTCATTAGGCAAATTAGTGCAATACTGCAATGCAGTG TGTTTGAATTATAGAATAATAGTTGAATGTAAGCTTTCATCTCAATCCATAAGAAAAGTTTTGTTCACCTTTTCTCTCGA AGTGAGGGTAATATCCGTTTGCACCGGTGTGTCAACGAGTACCCAAACATAGCAGTAGTTATTTTGCATAAGGAGTTTTC ACTTTGACTTCTTGTTTCCTACAATATGGTATCATATCCATGACATCCTTTTGTTGCTTTTTTGTTATGCATAGGTTGGA TTTGGACAGACAATTTGTACACCTCTAAGACCTCGTTGTGGAGAATGTGGCATAAGTGAGTTATGTCCATCAGCGTTCAA GGAGACCTCAAACTCAAGCCCTTCTTCCAAGTCCAGAAAGTCCAGACTCAACAAGAAGAAGCTTTAACATTGTCCCAGAA ACAAGCCAAGAAACTTTAACAAAACTAATTATTTTGGATTTGGGTTCCTTTTTTTGTCCCATATTTAACATGAGATGAGA TATATTAGGCTCACATTGCAACCAGCAGCATATCTAGATATGTATATTTTGTACAAATACTTGTATTTGGACCTTGAATG CTTAGTGGACCTGAAACTGTTTTCTTTATAGAGACTTTATCTTTTTTTTATCATTACTCTTTAGATTCTAAAGAAAAAAA AGGAAACAAATGTGAGTTTGTTGGTAAAAATTGTGTAATGCTCCAGATTGTTCTAAACAGGAAAAAAAAATAAAACAAAG GGTTATGATAATAATTATGTGTAAACTGTAAAGCATGTTATGTGGGGAGATAACTAGTCACCCTCGTTTGATTTCGTGCA TGCTAATCTCTTTTCTCAT
CDS sequence (LotjaGi3g1v0497800.1) extracted from Lotus japonicus Gifu v1.2 CDS.
ATGTTGGTCGTTTCCGCTCCTCCTCCCTTGTCTGGTTTGAGGAGAATCCAAGCTTTGATCATGTCTGAGACACCACGACG ATCTTACAAAGCTTCTCTCAGCAATACCAACACACCCACCTCGCTTGTTGAAGGCTCTGATTCCTCCAACGCCGCTTCTT CAGTGTCCCAACTTCGTGTCTTTGTGAGAAAAAACAAGAGACCCAGAAAAATGACTATGGAACTTCAACAAAAGGAGCCT CCTCCACCAACCCAGGACCATAAAAAGCTTGGTCCACCTGAAATTGAAGACTTTGCATACAGTGGAGCAAATGTGGCTGA GTGCAGAAAAACAGAATCGGTCTCAGATGTGGTCCTAGCAGAAGTTGCTTCTCCAACACCCAGCGGTGAATTACCTGCTC ACTGGGAAAAGGTGCTTGAGGGGATTCGCAAAATGAGGTGTTCTGCAGAAGCACCGGTAGACACTATGGGATGTGAGAAA GCTGGAAATACTCTACCTCCTAAGGAAAGAAGATTCGCTGTCCTGGTATCTTCTCTTTTATCAAGTCAAACCAAGGATCA TGTTAATCATGGAGCAATCCAACGTCTACTTCAAAATGATTTGCTTACGGCTGATGCAATCAACAATGCTGATGAAGAAA CCATCAAAAAGTTGATTTACCCTGTTGGGTTTTATACAAGAAAAGCTACTAACTTGAAAAAAATTGCAAATATTTGTCTC ATGAAGTATGACGGAGACATACCTAACTCACTTGAGCAACTACTTTTACTTCCAGGCATAGGTCCTAAGATGGCACATTT GGTTATGAATGTTGGATGGAACAATGTCCAAGGCATATGTGTAGATACTCATGTCCACCGCATTTGCAATAGGCTTGGGT GGGTGTCAAGATTGGGCACAAAACAGAAAACTTTGACACCTGAACAGACACGAGAGGCACTGCAAAGGTGGCTTCCAAGG GAAGAATGGGATCCCATAAATCCTCTATTGGTTGGATTTGGACAGACAATTTGTACACCTCTAAGACCTCGTTGTGGAGA ATGTGGCATAAGTGAGTTATGTCCATCAGCGTTCAAGGAGACCTCAAACTCAAGCCCTTCTTCCAAGTCCAGAAAGTCCA GACTCAACAAGAAGAAGCTTTAA
Protein sequence (LotjaGi3g1v0497800.1) extracted from Lotus japonicus Gifu v1.2 Proteins.
MLVVSAPPPLSGLRRIQALIMSETPRRSYKASLSNTNTPTSLVEGSDSSNAASSVSQLRVFVRKNKRPRKMTMELQQKEP PPPTQDHKKLGPPEIEDFAYSGANVAECRKTESVSDVVLAEVASPTPSGELPAHWEKVLEGIRKMRCSAEAPVDTMGCEK AGNTLPPKERRFAVLVSSLLSSQTKDHVNHGAIQRLLQNDLLTADAINNADEETIKKLIYPVGFYTRKATNLKKIANICL MKYDGDIPNSLEQLLLLPGIGPKMAHLVMNVGWNNVQGICVDTHVHRICNRLGWVSRLGTKQKTLTPEQTREALQRWLPR EEWDPINPLLVGFGQTICTPLRPRCGECGISELCPSAFKETSNSSPSSKSRKSRLNKKKL
Data for domain prediction are obtained with InterProScan, and merged with InterPro data obtained from the EB-eye REST service.
| Prediction algorithm | Identifier | Start | End | Length | E-value | InterPro ID |
|---|---|---|---|---|---|---|
| MobiDBLite | 24 | 90 | 67 | - | – | |
| MobiDBLite | 27 | 60 | 34 | - | – | |
| PANTHER | 62 | 369 | 308 | 2.9E-128 | – | |
| Hamap | 131 | 360 | 230 | 43.737 | ||
| SUPERFAMILY | 144 | 367 | 224 | 2.36E-59 | ||
| Gene3D | 164 | 270 | 107 | 1.3E-30 | – | |
| CDD | 172 | 334 | 163 | 1.15496E-49 | ||
| Pfam | 176 | 313 | 138 | 2.2E-21 | ||
| SMART | 180 | 336 | 157 | 1.9E-51 | ||
| Pfam | 242 | 270 | 29 | 1.6E-8 | ||
| ProSitePatterns | 245 | 274 | 30 | - | ||
| Gene3D | 271 | 361 | 91 | 2.7E-25 | ||
| SMART | 337 | 357 | 21 | 2.6E-6 | ||
| ProSitePatterns | 338 | 354 | 17 | - | ||
| MobiDBLite | 358 | 380 | 23 | - | – |
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | DNA binding | Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). | ||
| Molecular function | Catalytic activity | Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. | ||
| Molecular function | DNA-(apurinic or apyrimidinic site) endonuclease activity | Catalysis of the cleavage of the C-O-P bond in the AP site created when DNA glycosylase removes a damaged base, involved in the DNA base excision repair pathway (BER). | ||
| Cellular component | Nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. | ||
| Biological process | DNA repair | The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. | ||
| Biological process | Base-excision repair | In base excision repair, an altered base is removed by a DNA glycosylase enzyme, followed by excision of the resulting sugar phosphate. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. | ||
| Biological process | Base-excision repair, AP site formation | The formation of an AP site, a deoxyribose sugar with a missing base, by DNA glycosylase which recognizes an altered base in DNA and catalyzes its hydrolytic removal. This sugar phosphate is the substrate recognized by the AP endonuclease, which cuts the DNA phosphodiester backbone at the 5' side of the altered site to leave a gap which is subsequently repaired. | ||
| Molecular function | DNA N-glycosylase activity | Catalysis of the removal of damaged bases by cleaving the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar. The reaction releases a free base and leaves an apurinic/apyrimidinic (AP) site. | ||
| Molecular function | 4 iron, 4 sulfur cluster binding | Interacting selectively and non-covalently with a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands. |
Expression pattern of LotjaGi3g1v0497800.1, powered by ExpAt. For advanced configuration, data transformation and export options, view expression data in the ExpAt application.
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