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IPR010994 is a RuvA domain 2-like.
<p>In prokaryotes, RuvA, RuvB, and RuvC process the universal DNA intermediate of homologous recombination, termed Holliday junction. The tetrameric DNA helicase RuvA specifically binds to the Holliday junction and facilitates the isomerization of the junction from the stacked folded configuration to the square-planar structure [[cite:PUB00013198]]. In the RuvA tetramer, each subunit consists of three domains, I, II and III, where I and II form the major core that is responsible for Holliday junction binding and base pair rearrangements of Holliday junction executed at the crossover point, whereas domain III regulates branch migration through direct contact with RuvB. Domain 2 has a SAM (sterile alpha motif)-like α-bundle fold that occurs as a duplication containing two helix-hairpin-helix (HhH) motifs.</p> <p>The C-terminal domain (CTD) of the excision repair protein UvrC shows structural similarity to RuvA domain 2. The CTD of UvrC is essential for 5' incision in the prokaryotic nucleotide excision repair process, and acts to mediate structure-specific binding to single-stranded-double-stranded junction DNA [[cite:PUB00014056]].</p> <p>Domain III of NAD+-dependent DNA ligase consists of a duplication of two RuvA-like domains (four HhH motifs), and also contains a zinc-finger subdomain. DNA ligases catalyse the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD+ as a cofactor [[cite:PUB00007386]].</p>
This description is obtained from EB-eye REST.
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: transcription elongation factor SPT6-like [Cicer arietinum] gi|502127604|ref|XP_004499769.1| | 37 | ||
| – | PREDICTED: transcription elongation factor SPT6-like [Cicer arietinum] gi|502127604|ref|XP_004499769.1| | 37 | ||
| – | PREDICTED: kinesin-like protein KIF22-like [Glycine max] gi|356523149|ref|XP_003530204.1| | 19 | ||
| – | PREDICTED: transcription elongation factor SPT6-like isoform X2 [Cicer arietinum] gi|502107599|ref|XP_004493315.1| | 37 | ||
| – | PREDICTED: DNA repair endonuclease UVH1-like [Glycine max] gi|356541275|ref|XP_003539104.1| | 12 | ||
| – | DNA repair endonuclease UVH1 [Medicago truncatula] gi|357482211|ref|XP_003611391.1| | 12 | ||
| – | F13K23.4 protein [Theobroma cacao] gi|508725230|gb|EOY17127.1| | 4 | ||
| – | PREDICTED: kinesin-related protein 3-like [Glycine max] gi|356529192|ref|XP_003533180.1| | 7 | ||
| – | Kinesin-like protein; TAIR: AT5G02370.1 ATP binding microtubule motor family protein; Swiss-Prot: sp|Q5E913|KN10B_ARATH Kinesin-like protein KIN-10B; TrEMBL-Plants: tr|K7L1G4|K7L1G4_SOYBN Kinesin-like protein; Found in the gene: LotjaGi1g1v0580700 | 20 | ||
| – | Transcription elongation factor SPT6; TAIR: AT1G65440.2 global transcription factor group B1; Swiss-Prot: sp|A8MS85|SPT61_ARATH Transcription elongation factor SPT6 homolog; TrEMBL-Plants: tr|I1N8M6|I1N8M6_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0657000 | 45 | ||
| – | Transcription elongation factor SPT6; TAIR: AT1G65440.2 global transcription factor group B1; Swiss-Prot: sp|A8MS85|SPT61_ARATH Transcription elongation factor SPT6 homolog; TrEMBL-Plants: tr|I1N8M6|I1N8M6_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0657000 | 47 | ||
| – | Kinesin-like protein; TAIR: AT5G23910.1 ATP binding microtubule motor family protein; Swiss-Prot: sp|F4KEC6|KN10C_ARATH Kinesin-like protein KIN-10C; TrEMBL-Plants: tr|A0A072UBG9|A0A072UBG9_MEDTR ATP-binding microtubule motor family protein, putative; Found in the gene: LotjaGi2g1v0140300 | 17 | ||
| – | DNA repair endonuclease UVH1-like protein; TAIR: AT5G41150.1 Restriction endonuclease, type II-like superfamily protein; Swiss-Prot: sp|Q9LKI5|XPF_ARATH DNA repair endonuclease UVH1; TrEMBL-Plants: tr|K7LMX6|K7LMX6_SOYBN Uncharacterized protein; Found in the gene: LotjaGi2g1v0418900 | 12 | ||
| – | Transcription elongation factor SPT6; TAIR: AT1G65440.2 global transcription factor group B1; Swiss-Prot: sp|A8MS85|SPT61_ARATH Transcription elongation factor SPT6 homolog; TrEMBL-Plants: tr|A0A1J7IEI3|A0A1J7IEI3_LUPAN Uncharacterized protein; Found in the gene: LotjaGi3g1v0103300 | 41 | ||
| – | Transcription elongation factor SPT6; TAIR: AT1G65440.1 global transcription factor group B1; Swiss-Prot: sp|A8MS85|SPT61_ARATH Transcription elongation factor SPT6 homolog; TrEMBL-Plants: tr|A0A1J7IEI3|A0A1J7IEI3_LUPAN Uncharacterized protein; Found in the gene: LotjaGi3g1v0103300 | 41 | ||
| – | Transcription elongation factor SPT6; TAIR: AT1G65440.2 global transcription factor group B1; Swiss-Prot: sp|A8MS85|SPT61_ARATH Transcription elongation factor SPT6 homolog; TrEMBL-Plants: tr|A0A1J7IEI3|A0A1J7IEI3_LUPAN Uncharacterized protein; Found in the gene: LotjaGi3g1v0103300 | 41 | ||
| – | Transcription elongation factor SPT6; TAIR: AT1G65440.2 global transcription factor group B1; Swiss-Prot: sp|A8MS85|SPT61_ARATH Transcription elongation factor SPT6 homolog; TrEMBL-Plants: tr|A0A1J7IEI3|A0A1J7IEI3_LUPAN Uncharacterized protein; Found in the gene: LotjaGi3g1v0103300 | 42 | ||
| – | Transcription elongation factor SPT6; TAIR: AT1G65440.2 global transcription factor group B1; Swiss-Prot: sp|A8MS85|SPT61_ARATH Transcription elongation factor SPT6 homolog; TrEMBL-Plants: tr|A0A1J7IEI3|A0A1J7IEI3_LUPAN Uncharacterized protein; Found in the gene: LotjaGi3g1v0103300 | 41 | ||
| – | Transcription elongation factor SPT6; TAIR: AT1G65440.2 global transcription factor group B1; Swiss-Prot: sp|A8MS85|SPT61_ARATH Transcription elongation factor SPT6 homolog; TrEMBL-Plants: tr|A0A1J7IEI3|A0A1J7IEI3_LUPAN Uncharacterized protein; Found in the gene: LotjaGi3g1v0103300 | 41 | ||
| – | Transcription elongation factor SPT6; TAIR: AT1G65440.1 global transcription factor group B1; Swiss-Prot: sp|A8MS85|SPT61_ARATH Transcription elongation factor SPT6 homolog; TrEMBL-Plants: tr|A0A1J7IEI3|A0A1J7IEI3_LUPAN Uncharacterized protein; Found in the gene: LotjaGi3g1v0103300 | 41 | ||
| – | Transcription elongation factor SPT6; TAIR: AT1G65440.2 global transcription factor group B1; Swiss-Prot: sp|Q9CAM1|SPT62_ARATH Transcription elongation factor SPT6-like; TrEMBL-Plants: tr|A0A1J7IEI3|A0A1J7IEI3_LUPAN Uncharacterized protein; Found in the gene: LotjaGi3g1v0103300 | 41 | ||
| – | Transcription elongation factor SPT6; TAIR: AT1G65440.2 global transcription factor group B1; Swiss-Prot: sp|A8MS85|SPT61_ARATH Transcription elongation factor SPT6 homolog; TrEMBL-Plants: tr|A0A1J7IEI3|A0A1J7IEI3_LUPAN Uncharacterized protein; Found in the gene: LotjaGi3g1v0103300 | 41 | ||
| – | Transcription elongation factor SPT6; TAIR: AT1G65440.1 global transcription factor group B1; Swiss-Prot: sp|A8MS85|SPT61_ARATH Transcription elongation factor SPT6 homolog; TrEMBL-Plants: tr|A0A1J7IEI3|A0A1J7IEI3_LUPAN Uncharacterized protein; Found in the gene: LotjaGi3g1v0103300 | 41 | ||
| – | Transcription elongation factor SPT6; TAIR: AT1G65440.2 global transcription factor group B1; Swiss-Prot: sp|A8MS85|SPT61_ARATH Transcription elongation factor SPT6 homolog; TrEMBL-Plants: tr|A0A1J7IEI3|A0A1J7IEI3_LUPAN Uncharacterized protein; Found in the gene: LotjaGi3g1v0103300 | 41 | ||
| – | Transcription elongation factor SPT6; TAIR: AT1G65440.1 global transcription factor group B1; Swiss-Prot: sp|A8MS85|SPT61_ARATH Transcription elongation factor SPT6 homolog; TrEMBL-Plants: tr|A0A1J7IEI3|A0A1J7IEI3_LUPAN Uncharacterized protein; Found in the gene: LotjaGi3g1v0103300 | 41 | ||
| – | UvrABC system C; TAIR: AT1G12790.1 DNA ligase-like protein; Swiss-Prot: sp|F4IDW9|PTD_ARATH Protein PARTING DANCERS; TrEMBL-Plants: tr|A0A0R0H0J9|A0A0R0H0J9_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0543800 | 4 | ||
| – | UvrABC system protein C; TAIR: AT1G12790.1 DNA ligase-like protein; Swiss-Prot: sp|F4IDW9|PTD_ARATH Protein PARTING DANCERS; TrEMBL-Plants: tr|K7LSF1|K7LSF1_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0543800 | 5 | ||
| – | UvrABC system C; TAIR: AT1G12790.1 DNA ligase-like protein; Swiss-Prot: sp|F4IDW9|PTD_ARATH Protein PARTING DANCERS; TrEMBL-Plants: tr|A0A0R0H0J9|A0A0R0H0J9_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0543800 | 4 | ||
| – | DNA ligase-like protein; TAIR: AT3G05210.1 nucleotide repair protein; Swiss-Prot: sp|Q9MA98|ERCC1_ARATH DNA excision repair protein ERCC-1; TrEMBL-Plants: tr|K7LJM3|K7LJM3_SOYBN Uncharacterized protein; Found in the gene: LotjaGi5g1v0219300 | 11 | ||
| – | DNA ligase-like protein; TAIR: AT3G05210.1 nucleotide repair protein; Swiss-Prot: sp|Q9MA98|ERCC1_ARATH DNA excision repair protein ERCC-1; TrEMBL-Plants: tr|K7LJM3|K7LJM3_SOYBN Uncharacterized protein; Found in the gene: LotjaGi5g1v0219300 | 11 | ||
| – | Kinesin-like protein; TAIR: AT5G23910.1 ATP binding microtubule motor family protein; Swiss-Prot: sp|F4KEC6|KN10C_ARATH Kinesin-like protein KIN-10C; TrEMBL-Plants: tr|K7MI42|K7MI42_SOYBN Uncharacterized protein; Found in the gene: LotjaGi6g1v0356100_LC | 7 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| SSF47781 | SUPERFAMILY | 1 | 3.23 |