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IPR000870 is a Homoserine kinase.
<p>Saccharomyces cerevisiae strains containing the erg8-1 mutation are temperature sensitive for growth due to a defect in phosphomevalonate kinase, an enzyme of isoprene and ergosterol biosynthesis. Subcloning and DNA sequencing have defined the functional ERG8 regulon as an 850bp upstream region and an adjacent 1,272bp open reading frame. The deduced ERG8 protein contains 424 residues and shows no similarity to known proteins, except within a putative ATP-binding domain present in many kinases [[cite:PUB00003676]]. Enzymes that share the N-terminal Gly/Ser-rich putative ATP-binding region include galactokinase, homoserine kinase, mevalonate kinase and phosphomevalonate kinase. Homoserine kinase is a homodimeric enzyme involved in threonine biosynthesis. Sequence comparison of the yeast enzyme with the corresponding proteins from bacterial sources reveals the presence of several highly conserved regions, the pattern of occurrence of which suggests that the ancestral sequences might have been composed from separate (functional) domains. A block of similar residues, found towards the C terminus, is also present in many other proteins involved in threonine (or serine) metabolism; this motif may therefore represent the binding site for the hydroxy-amino acids. Limited similarity was detected between a motif conserved among the homoserine kinases and consensus sequences found in other mono- or dinucleotide-binding proteins [[cite:PUB00001384]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | Homoserine kinase activity | Catalysis of the reaction: L-homoserine + ATP = O-phospho-L-homoserine + ADP + 2 H(+). | ||
| Molecular function | ATP binding | Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. | ||
| Biological process | Threonine metabolic process | The chemical reactions and pathways involving threonine (2-amino-3-hydroxybutyric acid), a polar, uncharged, essential amino acid found in peptide linkage in proteins. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | Homoserine kinase-like [Glycine max] gi|359807161|ref|NP_001241610.1| | 18 | ||
| – | Homoserine kinase; TAIR: AT2G17265.1 homoserine kinase; Swiss-Prot: sp|Q8L7R2|KHSE_ARATH Homoserine kinase; TrEMBL-Plants: tr|D2DKF1|D2DKF1_SOYBN Homoserine kinase; Found in the gene: LotjaGi1g1v0000900 | 19 | ||
| – | Homoserine kinase; TAIR: AT2G17265.1 homoserine kinase; Swiss-Prot: sp|Q8L7R2|KHSE_ARATH Homoserine kinase; TrEMBL-Plants: tr|D2DKF1|D2DKF1_SOYBN Homoserine kinase; Found in the gene: LotjaGi1g1v0000900 | 19 | ||
| – | Homoserine kinase; TAIR: AT2G17265.1 homoserine kinase; Swiss-Prot: sp|Q8L7R2|KHSE_ARATH Homoserine kinase; TrEMBL-Plants: tr|D2DKF1|D2DKF1_SOYBN Homoserine kinase; Found in the gene: LotjaGi1g1v0000900 | 19 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| TIGR00191 | TIGRFAM | 1 | 25.00 |