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IPR001594 is a Palmitoyltransferase, DHHC domain.
<p>This entry refers to the DHHC domain, found in DHHC proteins which are palmitoyltransferases [[cite:PUB00053955]].</p> <p>Palmitoylation or, more specifically S-acylation, plays important roles in the regulation of protein localization, stability, and activity. It is a post-translational protein modification that involves the attachment of palmitic acid to Cys residues through a thioester linkage. Protein acyltransferases (PATs), also known as palmitoyltransferases, catalyse this reaction by transferring the palmitoyl group from palmitoyl-CoA to the thiol group of Cys residues. They are characterised by the presence of 50-residue-long domain called the DHHC domain, which in most but not all cases is also cysteine-rich and gets its name from a highly conserved DHHC signature tetrapeptide (Asp-His-His-Cys). The Cys residue within the DHHC domain forms a stable acyl intermediate and transfers the acyl chain to the Cys residues of a target protein [[cite:PUB00082711], [cite:PUB00082712]].</p> <p>Some of the proteins containing a DHHC domain are listed below:</p> <ul> <li>Drosophila DNZ1 protein [[cite:PUB00001882]]</li> <li>Mouse Abl-philin 2 (Aph2) protein. Interacts with c-Abl. May play a role in apoptosis [[cite:PUB00082716]]</li> <li>Mammalian ZDHHC9, an integral membrane protein [[cite:PUB00072195]]</li> <li>Yeast ankyrin repeat-containing protein AKR1 [[cite:PUB00033761]]</li> <li>Yeast Erf2 protein. This protein localizes to the endoplasmic reticulum and seems to be important for Ras function [[cite:PUB00005678]]</li> <li>Arabidopsis thaliana tip growth defective 1 [[cite:PUB00033762]]</li> </ul>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | Palmitoyltransferase activity | Catalysis of the transfer of a palmitoyl (CH3-[CH2]14-CO-) group to an acceptor molecule. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: probable S-acyltransferase At4g15080-like isoform X2 [Cicer arietinum] gi|502144352|ref|XP_004505666.1| | 10 | ||
| – | PREDICTED: probable S-acyltransferase At4g01730-like [Glycine max] gi|356533491|ref|XP_003535297.1| | 9 | ||
| – | PREDICTED: probable S-acyltransferase At3g51390-like [Cicer arietinum] gi|502161652|ref|XP_004512238.1| | 8 | ||
| – | PREDICTED: probable S-acyltransferase At3g09320-like isoform X1 [Cicer arietinum] gi|502167396|ref|XP_004514129.1| | 9 | ||
| – | PREDICTED: probable S-acyltransferase At3g09320-like [Glycine max] gi|356504262|ref|XP_003520916.1| | 9 | ||
| – | PREDICTED: probable S-acyltransferase At3g18620-like [Glycine max] gi|356530229|ref|XP_003533685.1| | 9 | ||
| – | PREDICTED: probable S-acyltransferase At4g24630-like isoform 1 [Glycine max] gi|356559619|ref|XP_003548096.1| | 10 | ||
| – | PREDICTED: probable S-acyltransferase At4g15080-like isoform 1 [Glycine max] gi|356517219|ref|XP_003527286.1| | 10 | ||
| – | PREDICTED: probable S-acyltransferase At3g26935-like [Glycine max] gi|356561478|ref|XP_003549008.1| | 10 | ||
| – | PREDICTED: probable S-acyltransferase At3g56930-like isoform X1 [Cicer arietinum] gi|502107536|ref|XP_004493294.1| | 9 | ||
| – | PREDICTED: probable S-acyltransferase At5g05070-like [Glycine max] gi|356570394|ref|XP_003553374.1| | 10 | ||
| – | PREDICTED: probable S-acyltransferase At3g04970-like [Glycine max] gi|356573040|ref|XP_003554673.1| | 8 | ||
| – | PREDICTED: probable S-acyltransferase At3g04970-like [Glycine max] gi|356573040|ref|XP_003554673.1| | 14 | ||
| – | PREDICTED: probable S-acyltransferase At4g00840-like [Cicer arietinum] gi|502114079|ref|XP_004494854.1| | 9 | ||
| – | PREDICTED: probable S-acyltransferase At1g69420-like [Glycine max] gi|356499847|ref|XP_003518747.1| | 10 | ||
| – | PREDICTED: probable S-acyltransferase At3g60800-like [Cicer arietinum] gi|502146557|ref|XP_004506505.1| | 9 | ||
| – | PREDICTED: probable S-acyltransferase At3g60800-like isoform 1 [Glycine max] gi|356496388|ref|XP_003517050.1| | 9 | ||
| – | PREDICTED: probable S-acyltransferase At3g60800-like [Glycine max] gi|356532103|ref|XP_003534613.1| | 9 | ||
| – | PREDICTED: probable S-acyltransferase At3g26935-like [Cicer arietinum] gi|502133336|ref|XP_004501727.1| | 10 | ||
| – | PREDICTED: probable S-acyltransferase At5g04270-like [Glycine max] gi|356576244|ref|XP_003556243.1| | 9 | ||
| – | Palmitoyltransferase SWF1 [Medicago truncatula] gi|357443583|ref|XP_003592069.1| | 10 | ||
| – | S-acyltransferase; TAIR: AT2G33640.1 DHHC-type zinc finger family protein; Swiss-Prot: sp|Q6DR03|ZDHC3_ARATH Protein S-acyltransferase 21; TrEMBL-Plants: tr|A0A151TCU7|A0A151TCU7_CAJCA S-acyltransferase; Found in the gene: LotjaGi1g1v0568100 | 10 | ||
| – | S-acyltransferase; TAIR: AT4G15080.1 DHHC-type zinc finger family protein; Swiss-Prot: sp|Q8L5Y5|ZDH17_ARATH Probable protein S-acyltransferase 19; TrEMBL-Plants: tr|A0A151TCU7|A0A151TCU7_CAJCA S-acyltransferase; Found in the gene: LotjaGi1g1v0568100 | 10 | ||
| – | S-acyltransferase; TAIR: AT4G15080.1 DHHC-type zinc finger family protein; Swiss-Prot: sp|Q8L5Y5|ZDH17_ARATH Probable protein S-acyltransferase 19; TrEMBL-Plants: tr|A0A151TCU7|A0A151TCU7_CAJCA S-acyltransferase; Found in the gene: LotjaGi1g1v0568100 | 10 | ||
| – | S-acyltransferase; TAIR: AT2G33640.1 DHHC-type zinc finger family protein; Swiss-Prot: sp|Q8L5Y5|ZDH17_ARATH Probable protein S-acyltransferase 19; TrEMBL-Plants: tr|A0A151TCU7|A0A151TCU7_CAJCA S-acyltransferase; Found in the gene: LotjaGi1g1v0568100 | 15 | ||
| – | S-acyltransferase; TAIR: AT3G26935.1 DHHC-type zinc finger family protein; Swiss-Prot: sp|Q0WQK2|ZDHC9_ARATH Probable protein S-acyltransferase 7; TrEMBL-Plants: tr|A0A151RWA0|A0A151RWA0_CAJCA S-acyltransferase; Found in the gene: LotjaGi1g1v0629000 | 10 | ||
| – | S-acyltransferase; TAIR: AT3G56930.1 DHHC-type zinc finger family protein; Swiss-Prot: sp|Q9M1K5|ZDH13_ARATH Probable protein S-acyltransferase 4; TrEMBL-Plants: tr|G7L4R1|G7L4R1_MEDTR S-acyltransferase; Found in the gene: LotjaGi1g1v0655000 | 9 | ||
| – | S-acyltransferase; TAIR: AT5G05070.1 DHHC-type zinc finger family protein; Swiss-Prot: sp|Q5PNZ1|ZDH21_ARATH Probable protein S-acyltransferase 3; TrEMBL-Plants: tr|K7MY14|K7MY14_SOYBN S-acyltransferase; Found in the gene: LotjaGi1g1v0655100 | 10 | ||
| – | S-acyltransferase; TAIR: AT5G05070.1 DHHC-type zinc finger family protein; Swiss-Prot: sp|Q5PNZ1|ZDH21_ARATH Probable protein S-acyltransferase 3; TrEMBL-Plants: tr|K7MY14|K7MY14_SOYBN S-acyltransferase; Found in the gene: LotjaGi1g1v0655100 | 10 | ||
| – | S-acyltransferase; TAIR: AT3G04970.1 DHHC-type zinc finger family protein; Swiss-Prot: sp|Q3EBC2|ZDHC5_ARATH Probable protein S-acyltransferase 17; TrEMBL-Plants: tr|A0A151R5F1|A0A151R5F1_CAJCA S-acyltransferase; Found in the gene: LotjaGi1g1v0776500 | 11 | ||
| – | S-acyltransferase; TAIR: AT4G00840.1 DHHC-type zinc finger family protein; Swiss-Prot: sp|Q5M757|ZDH15_ARATH Probable protein S-acyltransferase 12; TrEMBL-Plants: tr|A0A0S3S4S1|A0A0S3S4S1_PHAAN S-acyltransferase; Found in the gene: LotjaGi1g1v0795900 | 9 | ||
| – | S-acyltransferase; TAIR: AT3G18620.1 DHHC-type zinc finger family protein; Swiss-Prot: sp|Q9LIH7|ZDHC7_ARATH Protein S-acyltransferase 11; TrEMBL-Plants: tr|K7LGK1|K7LGK1_SOYBN S-acyltransferase; Found in the gene: LotjaGi2g1v0018200 | 9 | ||
| – | S-acyltransferase; TAIR: AT3G18620.1 DHHC-type zinc finger family protein; Swiss-Prot: sp|Q9LIH7|ZDHC7_ARATH Protein S-acyltransferase 11; TrEMBL-Plants: tr|K7LGK1|K7LGK1_SOYBN S-acyltransferase; Found in the gene: LotjaGi2g1v0018200 | 9 | ||
| – | S-acyltransferase; TAIR: AT3G18620.1 DHHC-type zinc finger family protein; Swiss-Prot: sp|Q9LIH7|ZDHC7_ARATH Protein S-acyltransferase 11; TrEMBL-Plants: tr|K7LGK1|K7LGK1_SOYBN S-acyltransferase; Found in the gene: LotjaGi2g1v0018200 | 9 | ||
| – | S-acyltransferase; TAIR: AT3G26935.1 DHHC-type zinc finger family protein; Swiss-Prot: sp|Q0WQK2|ZDHC9_ARATH Probable protein S-acyltransferase 7; TrEMBL-Plants: tr|I1MNM5|I1MNM5_SOYBN S-acyltransferase; Found in the gene: LotjaGi2g1v0103100 | 10 | ||
| – | S-acyltransferase; TAIR: AT4G24630.1 DHHC-type zinc finger family protein; Swiss-Prot: sp|Q9SB58|ZDH19_ARATH Protein S-acyltransferase 8; TrEMBL-Plants: tr|V7C3W2|V7C3W2_PHAVU S-acyltransferase; Found in the gene: LotjaGi2g1v0127100 | 10 | ||
| – | S-acyltransferase; TAIR: AT4G24630.1 DHHC-type zinc finger family protein; Swiss-Prot: sp|Q9SB58|ZDH19_ARATH Protein S-acyltransferase 8; TrEMBL-Plants: tr|V7C3W2|V7C3W2_PHAVU S-acyltransferase; Found in the gene: LotjaGi2g1v0127100 | 10 | ||
| – | S-acyltransferase; TAIR: AT1G69420.1 DHHC-type zinc finger family protein; Swiss-Prot: sp|Q9C533|ZDHC1_ARATH Probable protein S-acyltransferase 22; TrEMBL-Plants: tr|I1JE91|I1JE91_SOYBN S-acyltransferase; Found in the gene: LotjaGi2g1v0299600 | 10 | ||
| – | S-acyltransferase; TAIR: AT1G69420.1 DHHC-type zinc finger family protein; Swiss-Prot: sp|Q9C533|ZDHC1_ARATH Probable protein S-acyltransferase 22; TrEMBL-Plants: tr|I1JE91|I1JE91_SOYBN S-acyltransferase; Found in the gene: LotjaGi2g1v0299600 | 10 | ||
| – | S-acyltransferase; TAIR: AT1G69420.1 DHHC-type zinc finger family protein; Swiss-Prot: sp|Q9C533|ZDHC1_ARATH Probable protein S-acyltransferase 22; TrEMBL-Plants: tr|I1JE91|I1JE91_SOYBN S-acyltransferase; Found in the gene: LotjaGi2g1v0299600 | 10 | ||
| – | S-acyltransferase; TAIR: AT1G69420.1 DHHC-type zinc finger family protein; Swiss-Prot: sp|Q9C533|ZDHC1_ARATH Probable protein S-acyltransferase 22; TrEMBL-Plants: tr|I1JE91|I1JE91_SOYBN S-acyltransferase; Found in the gene: LotjaGi2g1v0299800 | 14 | ||
| – | S-acyltransferase; TAIR: AT1G69420.1 DHHC-type zinc finger family protein; Swiss-Prot: sp|Q9C533|ZDHC1_ARATH Probable protein S-acyltransferase 22; TrEMBL-Plants: tr|I1JE91|I1JE91_SOYBN S-acyltransferase; Found in the gene: LotjaGi2g1v0299800 | 14 | ||
| – | S-acyltransferase; TAIR: AT1G69420.1 DHHC-type zinc finger family protein; Swiss-Prot: sp|Q9C533|ZDHC1_ARATH Probable protein S-acyltransferase 22; TrEMBL-Plants: tr|I1JE91|I1JE91_SOYBN S-acyltransferase; Found in the gene: LotjaGi2g1v0299800 | 14 | ||
| – | S-acyltransferase; TAIR: AT3G51390.1 DHHC-type zinc finger family protein; Swiss-Prot: sp|Q7XA86|ZDH11_ARATH Protein S-acyltransferase 10; TrEMBL-Plants: tr|G7JYU0|G7JYU0_MEDTR S-acyltransferase; Found in the gene: LotjaGi2g1v0376200 | 9 | ||
| – | S-acyltransferase; TAIR: AT3G26935.1 DHHC-type zinc finger family protein; Swiss-Prot: sp|Q0WQK2|ZDHC9_ARATH Probable protein S-acyltransferase 7; TrEMBL-Plants: tr|B9IAF7|B9IAF7_POPTR S-acyltransferase; Found in the gene: LotjaGi3g1v0188800 | 10 | ||
| – | S-acyltransferase; TAIR: AT3G09320.1 DHHC-type zinc finger family protein; Swiss-Prot: sp|Q93VV0|ZDHC6_ARATH Probable protein S-acyltransferase 16; TrEMBL-Plants: tr|A0A1J7IG69|A0A1J7IG69_LUPAN Uncharacterized protein; Found in the gene: LotjaGi3g1v0226800 | 9 | ||
| – | S-acyltransferase; TAIR: AT3G60800.1 DHHC-type zinc finger family protein; Swiss-Prot: sp|Q8VYP5|ZDH14_ARATH Probable protein S-acyltransferase 14; TrEMBL-Plants: tr|G7JDF8|G7JDF8_MEDTR S-acyltransferase; Found in the gene: LotjaGi3g1v0433500 | 9 | ||
| – | S-acyltransferase; TAIR: AT4G15080.1 DHHC-type zinc finger family protein; Swiss-Prot: sp|Q8L5Y5|ZDH17_ARATH Probable protein S-acyltransferase 19; TrEMBL-Plants: tr|I1LPE3|I1LPE3_SOYBN S-acyltransferase; Found in the gene: LotjaGi3g1v0534300 | 10 | ||
| – | S-acyltransferase; TAIR: AT4G15080.1 DHHC-type zinc finger family protein; Swiss-Prot: sp|Q8L5Y5|ZDH17_ARATH Probable protein S-acyltransferase 19; TrEMBL-Plants: tr|I1LPE3|I1LPE3_SOYBN S-acyltransferase; Found in the gene: LotjaGi3g1v0534300 | 10 | ||
| – | S-acyltransferase; TAIR: AT4G15080.1 DHHC-type zinc finger family protein; Swiss-Prot: sp|Q8L5Y5|ZDH17_ARATH Probable protein S-acyltransferase 19; TrEMBL-Plants: tr|I1LPE3|I1LPE3_SOYBN S-acyltransferase; Found in the gene: LotjaGi3g1v0534300 | 10 | ||
| – | S-acyltransferase; TAIR: AT4G15080.1 DHHC-type zinc finger family protein; Swiss-Prot: sp|Q8L5Y5|ZDH17_ARATH Probable protein S-acyltransferase 19; TrEMBL-Plants: tr|I1LPE3|I1LPE3_SOYBN S-acyltransferase; Found in the gene: LotjaGi3g1v0534300 | 10 | ||
| – | S-acyltransferase; TAIR: AT4G15080.1 DHHC-type zinc finger family protein; Swiss-Prot: sp|Q8L5Y5|ZDH17_ARATH Probable protein S-acyltransferase 19; TrEMBL-Plants: tr|I1LPE3|I1LPE3_SOYBN S-acyltransferase; Found in the gene: LotjaGi3g1v0534300 | 10 | ||
| – | S-acyltransferase; TAIR: AT2G14255.1 Ankyrin repeat family protein with DHHC zinc finger domain-containing protein; Swiss-Prot: sp|Q3EC11|ZDHC2_ARATH Probable protein S-acyltransferase 23; TrEMBL-Plants: tr|A0A151SIB0|A0A151SIB0_CAJCA S-acyltransferase; Found in the gene: LotjaGi4g1v0042800 | 19 | ||
| – | S-acyltransferase; TAIR: AT3G60800.1 DHHC-type zinc finger family protein; Swiss-Prot: sp|Q8VYP5|ZDH14_ARATH Probable protein S-acyltransferase 14; TrEMBL-Plants: tr|A0A1J7HAG5|A0A1J7HAG5_LUPAN Uncharacterized protein; Found in the gene: LotjaGi4g1v0213600 | 9 | ||
| – | S-acyltransferase; TAIR: AT5G20350.1 Ankyrin repeat family protein with DHHC zinc finger domain-containing protein; Swiss-Prot: sp|Q52T38|ZDH22_ARATH Protein S-acyltransferase 24; TrEMBL-Plants: tr|A0A151SRG0|A0A151SRG0_CAJCA S-acyltransferase; Found in the gene: LotjaGi4g1v0280300 | 19 | ||
| – | S-acyltransferase; TAIR: AT5G20350.1 Ankyrin repeat family protein with DHHC zinc finger domain-containing protein; Swiss-Prot: sp|Q52T38|ZDH22_ARATH Protein S-acyltransferase 24; TrEMBL-Plants: tr|A0A151SRG0|A0A151SRG0_CAJCA S-acyltransferase; Found in the gene: LotjaGi4g1v0280300 | 19 | ||
| – | S-acyltransferase; TAIR: AT3G26935.1 DHHC-type zinc finger family protein; Swiss-Prot: sp|Q0WQK2|ZDHC9_ARATH Probable protein S-acyltransferase 7; TrEMBL-Plants: tr|I3SGK3|I3SGK3_LOTJA S-acyltransferase; Found in the gene: LotjaGi4g1v0419700 | 10 | ||
| – | S-acyltransferase; TAIR: AT4G01730.1 DHHC-type zinc finger family protein; Swiss-Prot: sp|Q9M115|ZDH16_ARATH Protein S-acyltransferase 18; TrEMBL-Plants: tr|A0A0L9TY88|A0A0L9TY88_PHAAN S-acyltransferase; Found in the gene: LotjaGi5g1v0237700 | 9 | ||
| – | S-acyltransferase; TAIR: AT5G04270.1 DHHC-type zinc finger family protein; Swiss-Prot: sp|Q500Z2|ZDH20_ARATH Probable protein S-acyltransferase 15; TrEMBL-Plants: tr|I1NHH9|I1NHH9_SOYBN S-acyltransferase; Found in the gene: LotjaGi5g1v0271400 | 9 | ||
| – | S-acyltransferase; TAIR: AT5G04270.1 DHHC-type zinc finger family protein; Swiss-Prot: sp|Q500Z2|ZDH20_ARATH Probable protein S-acyltransferase 15; TrEMBL-Plants: tr|A0A0B2NUQ6|A0A0B2NUQ6_GLYSO S-acyltransferase; Found in the gene: LotjaGi5g1v0271400 | 9 | ||
| – | S-acyltransferase; TAIR: AT4G24630.1 DHHC-type zinc finger family protein; Swiss-Prot: sp|Q9SB58|ZDH19_ARATH Protein S-acyltransferase 8; TrEMBL-Plants: tr|I3T0B6|I3T0B6_LOTJA S-acyltransferase; Found in the gene: LotjaGi5g1v0289000 | 10 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| mobidb-lite | MobiDBLite | 1 | 1.64 |