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IPR001915 is a Peptidase M48.
<p>This entry represents the largely extracellular catalytic region of CAAX prenyl protease homologues such as Human FACE-1 protease. These are metallopeptidases, with the characteristic HExxH motif giving the two histidine-zinc-ligands and an adjacent glutamate on the next helix being the third. The whole molecule folds to form a deep groove/cleft into which the substrate can fit [[cite:PUB00075616], [cite:PUB00075617]].</p> <p>This group of metallopeptidases belong to MEROPS peptidase family M48. Proteins with this domain are mostly described as probable protease htpX homologue ([ec:3.4.24]) or CAAX prenyl protease 1, which proteolytically removes the C-terminal three residues of farnesylated proteins. They are integral membrane proteins associated with the endoplasmic reticulum and Golgi, binding one zinc ion per subunit.</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | Metalloendopeptidase activity | Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. | ||
| Biological process | Proteolysis | The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: protease HtpX homolog 1-like [Cicer arietinum] gi|502165589|ref|XP_004513628.1| | 5 | ||
| – | PREDICTED: mitochondrial metalloendopeptidase OMA1 [Vitis vinifera] gi|225455604|ref|XP_002269952.1| | 8 | ||
| – | PREDICTED: mitochondrial metalloendopeptidase OMA1 [Vitis vinifera] gi|225455604|ref|XP_002269952.1| | 9 | ||
| – | PREDICTED: CAAX prenyl protease 1 homolog [Glycine max] gi|356568433|ref|XP_003552415.1| | 12 | ||
| – | PREDICTED: CAAX prenyl protease 1 homolog [Glycine max] gi|356568433|ref|XP_003552415.1| | 12 | ||
| – | Protease HtpX; TAIR: AT4G01320.1 Peptidase family M48 family protein; Swiss-Prot: sp|Q8RX88|FACE1_ARATH CAAX prenyl protease 1 homolog; TrEMBL-Plants: tr|A0A151TB32|A0A151TB32_CAJCA CAAX prenyl protease 1 isogeny; Found in the gene: LotjaGi1g1v0480400 | 13 | ||
| – | Protease HtpX; TAIR: AT4G01320.1 Peptidase family M48 family protein; Swiss-Prot: sp|Q8RX88|FACE1_ARATH CAAX prenyl protease 1 homolog; TrEMBL-Plants: tr|A0A151TB32|A0A151TB32_CAJCA CAAX prenyl protease 1 isogeny; Found in the gene: LotjaGi1g1v0480400 | 13 | ||
| – | Protease HtpX; TAIR: AT4G01320.1 Peptidase family M48 family protein; Swiss-Prot: sp|Q8RX88|FACE1_ARATH CAAX prenyl protease 1 homolog; TrEMBL-Plants: tr|A0A151TB32|A0A151TB32_CAJCA CAAX prenyl protease 1 isogeny; Found in the gene: LotjaGi1g1v0480400 | 13 | ||
| – | Protease HtpX; TAIR: AT3G27110.1 Peptidase family M48 family protein; Swiss-Prot: sp|Q8TP15|HTPX2_METAC Protease HtpX homolog 2; TrEMBL-Plants: tr|A0A151U0F2|A0A151U0F2_CAJCA Putative protease htpX isogeny 2; Found in the gene: LotjaGi1g1v0624100 | 7 | ||
| – | Protease HtpX; TAIR: AT3G27110.1 Peptidase family M48 family protein; Swiss-Prot: sp|Q8TP15|HTPX2_METAC Protease HtpX homolog 2; TrEMBL-Plants: tr|A0A151U0F2|A0A151U0F2_CAJCA Putative protease htpX isogeny 2; Found in the gene: LotjaGi1g1v0624100 | 7 | ||
| – | Mitochondrial metalloendopeptidase OMA1; TAIR: AT5G51740.2 Peptidase family M48 family protein; Swiss-Prot: sp|P36163|OMA1_YEAST Mitochondrial metalloendopeptidase OMA1; TrEMBL-Plants: tr|A0A151T455|A0A151T455_CAJCA Uncharacterized protein; Found in the gene: LotjaGi2g1v0154700 | 9 | ||
| – | Mitochondrial metalloendopeptidase OMA1; TAIR: AT5G51740.2 Peptidase family M48 family protein; Swiss-Prot: sp|P36163|OMA1_YEAST Mitochondrial metalloendopeptidase OMA1; TrEMBL-Plants: tr|A0A151T455|A0A151T455_CAJCA Uncharacterized protein; Found in the gene: LotjaGi6g1v0059300 | 9 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| cd07331 | CDD | 1 | 8.33 |