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IPR002082 is a Aspartate carbamoyltransferase.
<p>Aspartate carbamoyltransferase (ATCase) catalyses the formation of carbamoyl-aspartate in the pyrimidine biosynthesis pathway, by the association of aspartate and carbamoyl-phosphate. This is the commitment step in the Escherichia coli pathway and is regulated by feedback inhibition by CTP, the final product of the pathway [[cite:PUB00000720]].</p> <p>The structural organisation of the ATCase protein varies considerably between different organisms. In bacteria such as E. coli, Salmonella typhimurium and Serratia marcescens, the ATCase is a dodecamer of 2 catalytic (c) trimers and 3 regulatory (r) dimers. The catalytic domains are coded for by the pyrB gene [[cite:PUB00002421]], and the regulatory domains by pyrI [[cite:PUB00070200]]. In Gram-positive bacteria such as Bacillus subtilis, ATCase exists as a trimer of catalytic subunits, but unlike in E. coli, it neither contains nor binds to regulatory subunits. In eukaryotes, ATCase is found as a single domain in a multifunctional enzyme that contains activity for glutamine amidotransferase, carbamoylphosphate synthetase, dihydroorotase, and aspartate carbamoyltransferase.</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | Aspartate carbamoyltransferase activity | Catalysis of the reaction: L-aspartate + carbamoyl phosphate = N-carbamoyl-L-aspartate + H(+) + phosphate. | ||
| Biological process | 'de novo' pyrimidine nucleobase biosynthetic process | The chemical reactions and pathways resulting in the formation of pyrimidine nucleobases, 1,3-diazine, organic nitrogenous bases, beginning with the synthesis of a pyrimidine ring from simpler precursors. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: aspartate carbamoyltransferase 1, chloroplastic-like [Glycine max] gi|356501558|ref|XP_003519591.1| | 21 | ||
| – | Aspartate carbamoyltransferase; TAIR: AT3G20330.1 PYRIMIDINE B; Swiss-Prot: sp|Q43086|PYRB1_PEA Aspartate carbamoyltransferase 1, chloroplastic; TrEMBL-Plants: tr|I1JJC4|I1JJC4_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0025700 | 22 | ||
| – | Aspartate carbamoyltransferase; TAIR: AT3G20330.1 PYRIMIDINE B; Swiss-Prot: sp|Q43086|PYRB1_PEA Aspartate carbamoyltransferase 1, chloroplastic; TrEMBL-Plants: tr|I1JJC4|I1JJC4_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0025700 | 16 | ||
| – | Aspartate carbamoyltransferase; TAIR: AT3G20330.1 PYRIMIDINE B; Swiss-Prot: sp|Q43086|PYRB1_PEA Aspartate carbamoyltransferase 1, chloroplastic; TrEMBL-Plants: tr|I1JJC4|I1JJC4_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0025700 | 22 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| TIGR00670 | TIGRFAM | 1 | 25.00 |