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IPR002218 is a tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG-related.
<p>MnmG (also known as GidA) is a tRNA modification enzyme found in bacteria and mitochondria. Though its precise molecular function of these proteins is not known, it is involved in the 5-carboxymethylaminomethyl modification of the wobble uridine base in some tRNAs [[cite:PUB00043571], [cite:PUB00043572]]. Sequence variations in the human mitochondrial protein may influence the severity of aminoglycoside-induced deafness [[cite:PUB00043573]].</p> <p>This entry includes MnmG and related proteins, such as the methylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase enzyme TrmFO.</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Biological process | TRNA processing | The process in which a pre-tRNA molecule is converted to a mature tRNA, ready for addition of an aminoacyl group. | ||
| Molecular function | Flavin adenine dinucleotide binding | Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG-like isoform X2 [Cicer arietinum] gi|502183352|ref|XP_004517119.1| | 16 | ||
| – | PREDICTED: tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG-like isoform X2 [Cicer arietinum] gi|502183352|ref|XP_004517119.1| | 16 | ||
| – | TRNA uridine 5-carboxymethylaminomethyl modification enzyme mnmG [Medicago truncatula] gi|357520027|ref|XP_003630302.1| | 19 | ||
| – | TRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG; TAIR: AT2G13440.1 glucose-inhibited division family A protein; Swiss-Prot: sp|Q55694|MNMG_SYNY3 tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG; TrEMBL-Plants: tr|I1K513|I1K513_SOYBN Uncharacterized protein; Found in the gene: LotjaGi4g1v0410800 | 18 | ||
| – | TRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG; TAIR: AT2G13440.1 glucose-inhibited division family A protein; Swiss-Prot: sp|Q55694|MNMG_SYNY3 tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG; TrEMBL-Plants: tr|I1K513|I1K513_SOYBN Uncharacterized protein; Found in the gene: LotjaGi4g1v0410800 | 18 | ||
| – | TRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG; TAIR: AT2G13440.1 glucose-inhibited division family A protein; Swiss-Prot: sp|Q55694|MNMG_SYNY3 tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG; TrEMBL-Plants: tr|I1K513|I1K513_SOYBN Uncharacterized protein; Found in the gene: LotjaGi4g1v0410800 | 18 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| TIGR00136 | TIGRFAM | 1 | 16.67 |