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IPR002579 is a Peptide methionine sulphoxide reductase MrsB domain.
<p>Peptide methionine sulphoxide reductase (Msr) reverses the inactivation of many proteins due to the oxidation of critical methionine residues by reducing methionine sulphoxide, Met(O), to methionine [[cite:PUB00006537]]. It is present in most living organisms, and the cognate structural gene belongs to the so-called minimum gene set [[cite:PUB00015591], [cite:PUB00015592]].</p> <p>The domains: MsrA and MsrB, reduce different epimeric forms of methionine sulphoxide. This group represents MsrB, the crystal structure of which has been determined to 1.8A [[cite:PUB00014251]]. The overall structure shows no resemblance to the structures of MsrA ([interpro:IPR002569]) from other organisms; though the active sites show approximate mirror symmetry. In each case, conserved amino acid motifs mediate the stereo-specific recognition and reduction of the substrate. Unlike the MsrA domain, the MsrB domain activates the cysteine or selenocysteine nucleophile through a unique Cys-Arg-Asp/Glu catalytic triad. The collapse of the reaction intermediate most likely results in the formation of a sulphenic or selenenic acid moiety. Regeneration of the active site occurs through a series of thiol-disulphide exchange steps involving another active site Cys residue and thioredoxin.</p> <p>In a number of pathogenic bacteria, including Neisseria gonorrhoeae, the MsrA and MsrB domains are fused; the MsrA being N-terminal to MsrB. This arrangement is reversed in Treponema pallidum. In N. gonorrhoeae and Neisseria meningitidis, a thioredoxin domain is fused to the N terminus. This may function to reduce the active sites of the downstream MsrA and MsrB domains.</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | Peptide-methionine (R)-S-oxide reductase activity | Catalysis of the reaction: peptide-L-methionine + H(2)O + thioredoxin disulfide = peptide-L-methionine (R)-S-oxide + thioredoxin. Can act on oxidized methionine in peptide linkage with specificity for the R enantiomer. Thioredoxin disulfide is the oxidized form of thioredoxin. | ||
| Biological process | Oxidation-reduction process | A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | Uncharacterized protein TCM_035118 [Theobroma cacao] gi|508724400|gb|EOY16297.1| | 4 | ||
| – | Uncharacterized protein TCM_000130 [Theobroma cacao] gi|508698851|gb|EOX90747.1| | 6 | ||
| – | PREDICTED: peptide methionine sulfoxide reductase B1, chloroplastic-like [Cicer arietinum] gi|502166101|ref|XP_004513790.1| | 10 | ||
| – | PREDICTED: peptide methionine sulfoxide reductase B2, chloroplastic-like [Cicer arietinum] gi|502142277|ref|XP_004504878.1| | 9 | ||
| – | PREDICTED: peptide methionine sulfoxide reductase B3, chloroplastic-like [Cicer arietinum] gi|502078905|ref|XP_004486092.1| | 9 | ||
| – | Peptide methionine sulfoxide reductase msrB; TAIR: AT1G53670.1 methionine sulfoxide reductase B 1; Swiss-Prot: sp|Q9C8M2|MSRB1_ARATH Peptide methionine sulfoxide reductase B1, chloroplastic; TrEMBL-Plants: tr|I3SVJ6|I3SVJ6_LOTJA Uncharacterized protein; Found in the gene: LotjaGi3g1v0038500 | 11 | ||
| – | Peptide methionine sulfoxide reductase msrB; TAIR: AT4G21860.1 methionine sulfoxide reductase B 2; Swiss-Prot: sp|Q9C5C8|MSRB2_ARATH Peptide methionine sulfoxide reductase B2, chloroplastic; TrEMBL-Plants: tr|I3T0F9|I3T0F9_LOTJA Uncharacterized protein; Found in the gene: LotjaGi4g1v0042500 | 10 | ||
| – | Peptide methionine sulfoxide reductase msrB; TAIR: AT4G21860.1 methionine sulfoxide reductase B 2; Swiss-Prot: sp|Q10L32|MSRB5_ORYSJ Peptide methionine sulfoxide reductase B5; TrEMBL-Plants: tr|A0A0L9VEM3|A0A0L9VEM3_PHAAN Uncharacterized protein; Found in the gene: LotjaGi6g1v0302700 | 10 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| TIGR00357 | TIGRFAM | 1 | 12.50 |