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IPR002930 is a Glycine cleavage system H-protein.
<p>This is a family of glycine cleavage H-proteins, part of the glycine cleavage system (GCS) found in bacteria, archaea, and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and L-proteins) which catalyzes the oxidative cleavage of glycine [[cite:PUB00063633]]. The H-protein shuttles the methylamine group of glycine from the P-protein (glycine dehydrogenase) to the T-protein (aminomethyltransferase) via a lipoyl group, attached to a completely conserved lysine residue [[cite:PUB00004842]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Cellular component | Glycine cleavage complex | A protein complex that catalyzes the reversible oxidation of glycine. In E. coli, it has four components: dihydrolipoamide dehydrogenase, glycine dehydrogenase (decarboxylating), lipoyl-GcvH-protein and aminomethyltransferase, also known as L, P, H, and T. | ||
| Biological process | Glycine decarboxylation via glycine cleavage system | The chemical reactions and pathways resulting in the breakdown of glycine by oxidative cleavage to carbon dioxide, ammonia, and a methylene group, mediated by enzymes of the glycine cleavage complex. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: glycine cleavage system H protein, mitochondrial-like [Cicer arietinum] gi|502143341|ref|XP_004505304.1| | 16 | ||
| – | PREDICTED: ent-kaurenoic acid oxidase 2-like [Glycine max] gi|356495547|ref|XP_003516638.1| | 19 | ||
| – | Glycine cleavage system h protein; TAIR: AT1G32470.1 Single hybrid motif superfamily protein; Swiss-Prot: sp|Q39732|GCSH_FLAAN Glycine cleavage system H protein, mitochondrial; TrEMBL-Plants: tr|I3SRF4|I3SRF4_LOTJA Uncharacterized protein; Found in the gene: LotjaGi2g1v0415700 | 16 | ||
| – | Glycine cleavage system H family protein; TAIR: AT2G35120.1 Single hybrid motif superfamily protein; Swiss-Prot: sp|O82179|GCSH2_ARATH Glycine cleavage system H protein 2, mitochondrial; TrEMBL-Plants: tr|I3S7G1|I3S7G1_LOTJA Uncharacterized protein; Found in the gene: LotjaGi4g1v0083600 | 16 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| cd06848 | CDD | 1 | 25.00 |