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IPR004083

Source: InterPro

Description

IPR004083 is a Regulatory associated protein of TOR.

<p>This family consists of Raptor (regulatory associated protein of TOR) and its orthologs which includes Kog1p of Saccharomyces cerevisiae (Baker's yeast), a highly conserved 150kDa TOR-binding protein [[cite:PUB00015259], [cite:PUB00015260], [cite:PUB00015261]]. The target-of-rapamycin (TOR) proteins are protein kinases that were first identified in S. cerevisiae through mutants that conferred resistance to growth inhibition induced by the immunosuppressive macrolide rapamycin [[cite:PUB00000893]].</p> <p>All Raptor orthologs contain a unique conserved region in their N-terminal half (raptor N-terminal conserved, also called the RNC domain) followed by three HEAT (huntingtin, elongation factor 3, A subunit of protein phosphatase 2A and TOR1) repeats and seven WD-40 repeats near the C terminus. Research on mammalian Raptor suggests that its association with mTOR promotes the phosphorylation of downstream effectors in nutrient-stimulated cells [[cite:PUB00015259], [cite:PUB00015260]]. In concordance with these observations, the binding of TOR to Raptor or to Kog1p [[cite:PUB00015261]] is necessary for TOR signalling in vivo in Caenorhabditis elegans and S. cerevisiae [[cite:PUB00015260], [cite:PUB00015261]].</p> <p>The RNC domain consists of 3 blocks with at least 67 to 79% sequence similarity and is predicted to have a high propensity to form α helices. The RNC domain is characterised by the presence of invariant catalytic Cys-His dyad, which is structurally and evolutionarily related to known caspases, suggesting that the raptor proteins may have protease activity [[cite:PUB00015263]].</p>

This description is obtained from EB-eye REST.

Associated GO terms

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .

GO term Namespace Name Definition Relationships
GO:0031929
Biological process TOR signaling A series of molecular signals mediated by TOR (Target of rapamycin) proteins, members of the phosphoinositide (PI) 3-kinase related kinase (PIKK) family that act as serine/threonine kinases in response to nutrient availability or growth factors.
Subterm of
GO:0031931
Cellular component TORC1 complex A protein complex that contains at least TOR (target of rapamycin) and Raptor (regulatory-associated protein of TOR), or orthologs of, in complex with other signaling components. Mediates the phosphorylation and activation of S6K. In Saccharomyces, the complex contains Kog1p, Lst8p, Tco89p, and either Tor1p or Tor2p.
Subterm of

Associated Lotus transcripts 14

Transcript Name Description Predicted domains Domain count
Lj1g3v2442920.1
– PREDICTED: regulatory-associated protein of TOR 1-like [Glycine max] gi|356530199|ref|XP_003533671.1|
Domains
19
Lj1g3v2442920.2
– PREDICTED: regulatory-associated protein of TOR 1-like [Glycine max] gi|356530199|ref|XP_003533671.1|
Domains
19
Lj1g3v2442920.3
– PREDICTED: regulatory-associated protein of TOR 1-like isoform X2 [Cicer arietinum] gi|502104405|ref|XP_004492529.1|
Domains
9
Lj1g3v2442920.4
– PREDICTED: regulatory-associated protein of TOR 1-like [Glycine max] gi|356530199|ref|XP_003533671.1|
Domains
12
LotjaGi1g1v0452200.1
– Regulatory-associated protein of TOR 1; TAIR: AT3G08850.1 Regulatory-associated protein of TOR 1; Swiss-Prot: sp|Q93YQ1|RTOR1_ARATH Regulatory-associated protein of TOR 1; TrEMBL-Plants: tr|V7B2P2|V7B2P2_PHAVU Uncharacterized protein; Found in the gene: LotjaGi1g1v0452200
Domains
21
LotjaGi1g1v0452200.10
– Regulatory-associated protein of TOR 1; TAIR: AT3G08850.1 Regulatory-associated protein of TOR 1; Swiss-Prot: sp|Q93YQ1|RTOR1_ARATH Regulatory-associated protein of TOR 1; TrEMBL-Plants: tr|V7B2P2|V7B2P2_PHAVU Uncharacterized protein; Found in the gene: LotjaGi1g1v0452200
Domains
16
LotjaGi1g1v0452200.2
– Regulatory-associated protein of TOR 1; TAIR: AT3G08850.1 Regulatory-associated protein of TOR 1; Swiss-Prot: sp|Q93YQ1|RTOR1_ARATH Regulatory-associated protein of TOR 1; TrEMBL-Plants: tr|V7B2P2|V7B2P2_PHAVU Uncharacterized protein; Found in the gene: LotjaGi1g1v0452200
Domains
18
LotjaGi1g1v0452200.3
– Regulatory-associated protein of TOR 1; TAIR: AT3G08850.1 Regulatory-associated protein of TOR 1; Swiss-Prot: sp|Q93YQ1|RTOR1_ARATH Regulatory-associated protein of TOR 1; TrEMBL-Plants: tr|V7B2P2|V7B2P2_PHAVU Uncharacterized protein; Found in the gene: LotjaGi1g1v0452200
Domains
27
LotjaGi1g1v0452200.4
– Regulatory-associated protein of TOR 1; TAIR: AT3G08850.1 Regulatory-associated protein of TOR 1; Swiss-Prot: sp|Q93YQ1|RTOR1_ARATH Regulatory-associated protein of TOR 1; TrEMBL-Plants: tr|V7B2P2|V7B2P2_PHAVU Uncharacterized protein; Found in the gene: LotjaGi1g1v0452200
Domains
21
LotjaGi1g1v0452200.5
– Regulatory-associated protein of TOR 1; TAIR: AT3G08850.1 Regulatory-associated protein of TOR 1; Swiss-Prot: sp|Q93YQ1|RTOR1_ARATH Regulatory-associated protein of TOR 1; TrEMBL-Plants: tr|V7B2P2|V7B2P2_PHAVU Uncharacterized protein; Found in the gene: LotjaGi1g1v0452200
Domains
21
LotjaGi1g1v0452200.6
– Regulatory-associated protein of TOR 1; TAIR: AT3G08850.1 Regulatory-associated protein of TOR 1; Swiss-Prot: sp|Q93YQ1|RTOR1_ARATH Regulatory-associated protein of TOR 1; TrEMBL-Plants: tr|V7B2P2|V7B2P2_PHAVU Uncharacterized protein; Found in the gene: LotjaGi1g1v0452200
Domains
21
LotjaGi1g1v0452200.7
– Regulatory-associated protein of TOR 1; TAIR: AT3G08850.1 Regulatory-associated protein of TOR 1; Swiss-Prot: sp|Q93YQ1|RTOR1_ARATH Regulatory-associated protein of TOR 1; TrEMBL-Plants: tr|V7B2P2|V7B2P2_PHAVU Uncharacterized protein; Found in the gene: LotjaGi1g1v0452200
Domains
18
LotjaGi1g1v0452200.8
– Regulatory-associated protein of TOR 1; TAIR: AT3G08850.1 Regulatory-associated protein of TOR 1; Swiss-Prot: sp|Q93YQ1|RTOR1_ARATH Regulatory-associated protein of TOR 1; TrEMBL-Plants: tr|V7B2P2|V7B2P2_PHAVU Uncharacterized protein; Found in the gene: LotjaGi1g1v0452200
Domains
12
LotjaGi1g1v0452200.9
– Regulatory-associated protein of TOR 1; TAIR: AT3G08850.1 Regulatory-associated protein of TOR 1; Swiss-Prot: sp|Q93YQ1|RTOR1_ARATH Regulatory-associated protein of TOR 1; TrEMBL-Plants: tr|V7B2P2|V7B2P2_PHAVU Uncharacterized protein; Found in the gene: LotjaGi1g1v0452200
Domains
21

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space:

Predicted domain Source Observations Saturation (%)
mobidb-lite MobiDBLite 1 7.14