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IPR004582 is a Checkpoint protein Rad17/Rad24.
<p>This entry represents checkpoint protein Rad24 from budding yeasts and its homologue, Rad17 from other organisms.</p> <p>In Saccharomyces cerevisiae, Rad24 forms a complex with replication factor C (RFC) proteins, including Rfc2, Rfc3, Rfc4, and Rfc5. When DNA damage is detected, the Rad24-RFC complex loads Rad17-Mec3-Ddc1 complex onto chromatin and activates DNA damage checkpoint, which then leads to cell cycle arrest and DNA repair [[cite:PUB00059229]]. The Rad24-RFC complex is involved in both the mitotic and meiotic checkpoints [[cite:PUB00062364]]. Besides checkpoint activation, Rad24 is also involved in double-strand break ends processing, DNA repair and telomere maintenance [[cite:PUB00062365], [cite:PUB00062366], [cite:PUB00062367], [cite:PUB00062368]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Biological process | DNA repair | The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. | ||
| Cellular component | Host cell nucleus | A membrane-bounded organelle as it is found in the host cell in which chromosomes are housed and replicated. The host is defined as the larger of the organisms involved in a symbiotic interaction. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | Cell cycle checkpoint protein RAD17 [Medicago truncatula] gi|357517967|ref|XP_003629272.1| | 2 | ||
| – | PREDICTED: cell cycle checkpoint protein RAD17-like [Cicer arietinum] gi|502153551|ref|XP_004509381.1| | 6 | ||
| – | PREDICTED: cell cycle checkpoint protein RAD17-like [Cicer arietinum] gi|502153551|ref|XP_004509381.1| | 9 | ||
| – | Replication factor C large subunit [Medicago truncatula] gi|357438631|ref|XP_003589591.1| | 8 | ||
| – | Replication factor C large subunit [Medicago truncatula] gi|357438631|ref|XP_003589591.1| | 10 | ||
| – | ATPase family AAA domain-containing protein [Medicago truncatula] gi|357461523|ref|XP_003601043.1| | 4 | ||
| – | Replication factor C large subunit [Medicago truncatula] gi|357438631|ref|XP_003589591.1| | 4 | ||
| – | Replication factor C large subunit [Medicago truncatula] gi|357438631|ref|XP_003589591.1| | 4 | ||
| – | Replication factor C subunit 5; TAIR: AT1G77620.1 P-loop containing nucleoside triphosphate hydrolases superfamily protein; Swiss-Prot: sp|Q96QE3|ATAD5_HUMAN ATPase family AAA domain-containing protein 5; TrEMBL-Plants: tr|K7M6V1|K7M6V1_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0160400 | 9 | ||
| – | Replication factor C large subunit; TAIR: AT1G77620.1 P-loop containing nucleoside triphosphate hydrolases superfamily protein; Swiss-Prot: sp|Q4QY64|ATAD5_MOUSE ATPase family AAA domain-containing protein 5; TrEMBL-Plants: tr|G7J301|G7J301_MEDTR p-loop nucleoside triphosphate hydrolase superfamily protein, putative; Found in the gene: LotjaGi1g1v0259500 | 9 | ||
| – | Cell cycle checkpoint protein RAD17, putative; TAIR: AT5G66130.1 RADIATION SENSITIVE 17; Swiss-Prot: sp|Q9MBA3|RAD17_ARATH Cell cycle checkpoint protein RAD17; TrEMBL-Plants: tr|G7LB75|G7LB75_MEDTR Cell cycle checkpoint protein RAD17, putative; Found in the gene: LotjaGi4g1v0130200 | 10 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| mobidb-lite | MobiDBLite | 1 | 9.09 |