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IPR004598 is a Transcription factor TFIIH subunit p52/Tfb2.
<p>This entry represents the p52/Tfb2 subunit in the TFIIH complex, which is not only required for transcription but also plays a central role in DNA repair. The TFIIH multiprotein complex consists of a 7-subunit core (XPB, p62, p52, p44, p34, and TTDA) that is associated with a 3-subunit CDK-activating kinase module (MAT1, cyclin H and Cdk7) [[cite:PUB00062813], [cite:PUB00062739], [cite:PUB00062740]]. The p52 subunit interacts with subunit XPB, which is an ATP-dependent 3'-5' DNA helicase, and stimulates its ATPase activity [[cite:PUB00089653]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Cellular component | Transcription factor TFIIH core complex | The 7 subunit core of TFIIH that is a part of either the general transcription factor holo-TFIIH or the nucleotide-excision repair factor 3 complex. In S. cerevisiae/humans the complex is composed of: Ssl2/XPB, Tfb1/p62, Tfb2/p52, Ssl1/p44, Tfb4/p34, Tfb5/p8 and Rad3/XPD. | ||
| Molecular function | ATPase activator activity | Binds to and increases the ATP hydrolysis activity of an ATPase. | ||
| Biological process | Nucleotide-excision repair | A DNA repair process in which a small region of the strand surrounding the damage is removed from the DNA helix as an oligonucleotide. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. Nucleotide excision repair recognizes a wide range of substrates, including damage caused by UV irradiation (pyrimidine dimers and 6-4 photoproducts) and chemicals (intrastrand cross-links and bulky adducts). |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: general transcription factor IIH subunit 4-like [Cicer arietinum] gi|502142615|ref|XP_004505045.1| | 3 | ||
| – | PREDICTED: general transcription factor IIH subunit 4-like [Cicer arietinum] gi|502142615|ref|XP_004505045.1| | 4 | ||
| – | Transcription factor; TAIR: AT4G17020.1 transcription factor-like protein; Swiss-Prot: sp|Q680U9|TFB2_ARATH RNA polymerase II transcription factor B subunit 2; TrEMBL-Plants: tr|G7ZZ96|G7ZZ96_MEDTR General transcription factor IIH protein; Found in the gene: LotjaGi4g1v0055200 | 7 | ||
| – | Transcription factor; TAIR: AT4G17020.3 transcription factor-like protein; Swiss-Prot: sp|Q680U9|TFB2_ARATH RNA polymerase II transcription factor B subunit 2; TrEMBL-Plants: tr|A0A1J7GYK6|A0A1J7GYK6_LUPAN Uncharacterized protein; Found in the gene: LotjaGi4g1v0055200 | 3 | ||
| – | Transcription factor; TAIR: AT4G17020.1 transcription factor-like protein; Swiss-Prot: sp|Q680U9|TFB2_ARATH RNA polymerase II transcription factor B subunit 2; TrEMBL-Plants: tr|A0A1J7GYK6|A0A1J7GYK6_LUPAN Uncharacterized protein; Found in the gene: LotjaGi4g1v0055200 | 3 | ||
| – | Transcription factor; TAIR: AT4G17020.1 transcription factor-like protein; Swiss-Prot: sp|Q680U9|TFB2_ARATH RNA polymerase II transcription factor B subunit 2; TrEMBL-Plants: tr|A0A0R0J5X6|A0A0R0J5X6_SOYBN Uncharacterized protein; Found in the gene: LotjaGi4g1v0055200 | 6 | ||
| – | Transcription factor; TAIR: AT4G17020.1 transcription factor-like protein; Swiss-Prot: sp|Q680U9|TFB2_ARATH RNA polymerase II transcription factor B subunit 2; TrEMBL-Plants: tr|G7ZZ96|G7ZZ96_MEDTR General transcription factor IIH protein; Found in the gene: LotjaGi4g1v0055200 | 7 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| TIGR00625 | TIGRFAM | 1 | 14.29 |