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IPR004651 is a Histidine biosynthesis, HisF.
<p>Histidine is formed by several complex and distinct biochemical reactions catalysed by eight enzymes. Proteins involved in steps 4 and 6 of the histidine biosynthesis pathway are contained in one family. These enzymes are called His6 and His7 in eukaryotes and HisA and HisF in prokaryotes [[cite:PUB00039276], [cite:PUB00081081], [cite:PUB00025531]]. HisA is a phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide isomerase ([ec:5.3.1.16]), involved in the fourth step of histidine biosynthesis. The bacterial HisF protein is a cyclase which catalyzes the cyclization reaction that produces D-erythro-imidazole glycerol phosphate during the sixth step of histidine biosynthesis. HisF is also known as imidazole glycerol phosphate synthase [[cite:PUB00081080], [cite:PUB00081035], [cite:PUB00021977]]. The yeast His7 protein is a bifunctional protein which catalyzes an amido-transferase reaction that generates imidazole-glycerol phosphate and 5-aminoimidazol-4-carboxamide. The latter is the ribonucleotide used for purine biosynthesis. The enzyme also catalyzes the cyclization reaction that produces D-erythro-imidazole glycerol phosphate, and is involved in the fifth and sixth steps in histidine biosynthesis.</p> <p>This family describes the histidine biosynthesis protein, HisF.</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Biological process | Histidine biosynthetic process | The chemical reactions and pathways resulting in the formation of histidine, 2-amino-3-(1H-imidazol-4-yl)propanoic acid. | ||
| Molecular function | Imidazoleglycerol-phosphate synthase activity | Catalysis of the reaction: phosphoribulosylformimino-AICAR-P + L-glutamine = D-erythro-imidazole-glycerol-phosphate + aminoimidazole carboxamide ribonucleotide + L-glutamate + 2 H(+). |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: imidazole glycerol phosphate synthase hisHF, chloroplastic-like [Glycine max] gi|356567431|ref|XP_003551923.1| | 23 | ||
| – | PREDICTED: imidazole glycerol phosphate synthase hisHF, chloroplastic-like [Glycine max] gi|356567431|ref|XP_003551923.1| | 23 | ||
| – | Imidazole glycerol phosphate synthase subunit HisF; TAIR: AT4G26900.1 HIS HF; Swiss-Prot: sp|Q9SZ30|HIS4_ARATH Imidazole glycerol phosphate synthase hisHF, chloroplastic; TrEMBL-Plants: tr|I1N0Y1|I1N0Y1_SOYBN Uncharacterized protein; Found in the gene: LotjaGi4g1v0002000 | 22 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| cd04731 | CDD | 1 | 33.33 |