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IPR014640 is a Imidazole glycerol phosphate synthase HisHF.
<p>Members of this group are eukaryotic bifunctional enzymes with glutamine amidotransferase ([interpro:IPR017926]) and cyclase activities ([interpro:IPR006062]) that catalyse the fifth and sixth steps of the histidine biosynthetic pathway. In eubacteria, these steps are catalysed by a complex formed by two subunits, namely the glutamine amidotransferase HisH ([InterPro:IPR010139]) and the cyclase HisF which are encoded in the same operon [[cite:PUB00027820]].</p> <p>The catalytic activity has been assessed for many members, mainly by complementation assays. The Saccharomyces cerevisiae (Baker's yeast) member is able to suppress His auxotrophy of corresponding Escherichia coli hisH and hisF mutants [[cite:PUB00017574]]. In plants, hisHF cDNA from Emericella nidulans (Aspergillus nidulans) and Arabidopsis thaliana (Mouse-ear cress) complemented a S. cerevisiae<i>his7Delta</i>strain [[cite:PUB00017573], [cite:PUB00027875]]. In addition, A. nidulans cDNA complemented E. coli<i>hisH</i>and<i>hisF</i>mutant strains [[cite:PUB00027875]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Biological process | Histidine biosynthetic process | The chemical reactions and pathways resulting in the formation of histidine, 2-amino-3-(1H-imidazol-4-yl)propanoic acid. | ||
| Molecular function | Imidazoleglycerol-phosphate synthase activity | Catalysis of the reaction: phosphoribulosylformimino-AICAR-P + L-glutamine = D-erythro-imidazole-glycerol-phosphate + aminoimidazole carboxamide ribonucleotide + L-glutamate + 2 H(+). | ||
| Molecular function | Transferase activity, transferring pentosyl groups | Catalysis of the transfer of a pentosyl group from one compound (donor) to another (acceptor). | ||
| Molecular function | Oxo-acid-lyase activity | Catalysis of the cleavage of a C-C bond by other means than by hydrolysis or oxidation, of a 3-hydroxy acid. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: imidazole glycerol phosphate synthase hisHF, chloroplastic-like [Glycine max] gi|356567431|ref|XP_003551923.1| | 23 | ||
| – | PREDICTED: imidazole glycerol phosphate synthase hisHF, chloroplastic-like [Glycine max] gi|356567431|ref|XP_003551923.1| | 23 | ||
| – | Imidazole glycerol phosphate synthase subunit HisF; TAIR: AT4G26900.1 HIS HF; Swiss-Prot: sp|Q9SZ30|HIS4_ARATH Imidazole glycerol phosphate synthase hisHF, chloroplastic; TrEMBL-Plants: tr|I1N0Y1|I1N0Y1_SOYBN Uncharacterized protein; Found in the gene: LotjaGi4g1v0002000 | 22 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| cd04731 | CDD | 1 | 33.33 |