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IPR010139 is a Imidazole glycerol phosphate synthase, subunit H.
<p>Imidazole glycerol phosphate synthetase (IGPS) is a key metabolic enzyme, which links amino acid and nucleotide biosynthesis: it catalyses the closure of the imidazole ring within histidine biosynthesis (fifth step), and provides the substrate for de novo purine biosynthesis. IGPS consists of two different subunits: HisH, a glutamine amidotransferase (glutaminase), and HisF, a synthase (cyclase). HisH functions to provide a source of nitrogen, which is required for the synthesis of histidine and purines. In the HisH glutaminase reaction, the hydrolysis of glutamine yields ammonia, which is then used by HisF in the subsequent synthase reaction. The X-ray structure of the HisH/HisF heterodimer of IGPS reveals a putative tunnel for the transfer of ammonia from HisH to HisF via a (β-α)8 barrel fold within HisF that abuts HisH [[cite:PUB00014925]]. Ammonia tunnels connect the glutaminase and synthase active sites.</p> <p>HisH belongs to a large group of enzymes found in diverse and fundamental anabolic pathways. These enzymes share a common domain, referred to as the type-I glutamine amidotransferase (GATase) domain, which can occur either as single polypeptides (as with HisH) or as domains of large multifunctional proteins.</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Biological process | Histidine biosynthetic process | The chemical reactions and pathways resulting in the formation of histidine, 2-amino-3-(1H-imidazol-4-yl)propanoic acid. | ||
| Molecular function | Transferase activity, transferring pentosyl groups | Catalysis of the transfer of a pentosyl group from one compound (donor) to another (acceptor). |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: imidazole glycerol phosphate synthase hisHF, chloroplastic-like [Glycine max] gi|356567431|ref|XP_003551923.1| | 23 | ||
| – | PREDICTED: imidazole glycerol phosphate synthase hisHF, chloroplastic-like [Glycine max] gi|356567431|ref|XP_003551923.1| | 23 | ||
| – | PREDICTED: imidazole glycerol phosphate synthase hisHF, chloroplastic-like [Glycine max] gi|356567431|ref|XP_003551923.1| | 18 | ||
| – | Imidazole glycerol phosphate synthase subunit HisF; TAIR: AT4G26900.1 HIS HF; Swiss-Prot: sp|Q9SZ30|HIS4_ARATH Imidazole glycerol phosphate synthase hisHF, chloroplastic; TrEMBL-Plants: tr|I1N0Y1|I1N0Y1_SOYBN Uncharacterized protein; Found in the gene: LotjaGi4g1v0002000 | 22 | ||
| – | Imidazole glycerol phosphate synthase subunit hisH; TAIR: AT4G26900.1 HIS HF; Swiss-Prot: sp|Q9SZ30|HIS4_ARATH Imidazole glycerol phosphate synthase hisHF, chloroplastic; TrEMBL-Plants: tr|A0A0L9TE25|A0A0L9TE25_PHAAN Uncharacterized protein; Found in the gene: LotjaGi4g1v0002000 | 9 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| TIGR01855 | TIGRFAM | 1 | 20.00 |