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IPR005722 is a ATP synthase, F1 complex, beta subunit.
<p>This entry represents the beta subunit found in the F1 complex of F-ATPases.</p> <p>F-ATPases (also known as ATP synthases, F1F0-ATPase, or H(+)-transporting two-sector ATPase) ([ec:7.1.2.2]) are composed of two linked complexes: the F1 ATPase complex is the catalytic core and is composed of 5 subunits (alpha, beta, gamma, delta, epsilon), while the F0 ATPase complex is the membrane-embedded proton channel that is composed of at least 3 subunits (A-C), with additional subunits in mitochondria. Both the F1 and F0 complexes are rotary motors that are coupled back-to-back. In the F1 complex, the central gamma subunit forms the rotor inside the cylinder made of the α(3)β(3) subunits, while in the F0 complex, the ring-shaped C subunits forms the rotor. The two rotors rotate in opposite directions, but the F0 rotor is usually stronger, using the force from the proton gradient to push the F1 rotor in reverse in order to drive ATP synthesis [[cite:PUB00009752]]. These ATPases can also work in reverse in bacteria, hydrolysing ATP to create a proton gradient.</p> <p>In F-ATPases, there are three copies each of the alpha and beta subunits that form the catalytic core of the F1 complex, while the remaining F1 subunits (gamma, delta, epsilon) form part of the stalks. There is a substrate-binding site on each of the alpha and beta subunits, those on the beta subunits being catalytic, while those on the alpha subunits are regulatory. The alpha and beta subunits form a cylinder that is attached to the central stalk. The alpha/beta subunits undergo a sequence of conformational changes leading to the formation of ATP from ADP, which are induced by the rotation of the gamma subunit, itself is driven by the movement of protons through the F0 complex C subunit [[cite:PUB00020611], [cite:PUB00007884]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Biological process | ATP synthesis coupled proton transport | The transport of protons across a membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis. | ||
| Cellular component | Proton-transporting ATP synthase complex, catalytic core F(1) | The sector of a hydrogen-transporting ATP synthase complex in which the catalytic activity resides; it comprises the catalytic core and central stalk, and is peripherally associated with a membrane, such as the plasma membrane or the mitochondrial inner membrane, when the entire ATP synthase is assembled. | ||
| Molecular function | Proton-transporting ATP synthase activity, rotational mechanism | Enables the transfer of protons from one side of a membrane to the other according to the reaction: ADP + H2O + phosphate + H+(in) = ATP + H+(out), by a rotational mechanism. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: ATP synthase subunit beta, mitochondrial-like [Glycine max] gi|356575611|ref|XP_003555932.1| | 17 | ||
| – | ATP synthase CF1 beta subunit [Lotus japonicus] gi|13518421|ref|NP_084781.1| | 23 | ||
| – | ATP synthase subunit beta; TAIR: AT5G08680.1 ATP synthase alpha/beta family protein; Swiss-Prot: sp|P17614|ATPBM_NICPL ATP synthase subunit beta, mitochondrial; TrEMBL-Plants: tr|A0A0L9TFH9|A0A0L9TFH9_PHAAN ATP synthase subunit beta; Found in the gene: LotjaGi5g1v0332700 | 35 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| mobidb-lite | MobiDBLite | 1 | 33.33 |