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IPR005874 is a Eukaryotic translation initiation factor SUI1.
<p>SUI1/eIF1 (eukaryotic initiation factor 1) plays an important role in accurate initiator codon recognition during translation initiation. eIF1 interacts with 18S rRNA in the 40S ribosomal subunit during eukaryotic translation initiation. Point mutations in the yeast eIF1 implicate the protein in maintaining accurate start-site selection but its mechanism of action is unknown [[cite:PUB00080467]].</p> <p>Cells have evolved elaborate mechanisms to rid themselves of aberrant proteins and transcripts. The nonsense-mediated mRNA decay pathway (NMD) is an example of a pathway that eliminates aberrant mRNAs. In addition to its role in recognition of the AUG codon during translation initiation and maintenance of the appropriate reading frame during translation elongation by directing the ribosome to the proper start site of translation by functioning in concert with eIF-2 and the initiator tRNA-Met, the SUI1 protein plays a role in the NMD pathway [[cite:PUB00017640]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | Translation initiation factor activity | Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | Translation factor SUI1 [Aeschynomene evenia] gi|426207902|gb|AFY13590.1| | 11 | ||
| – | PREDICTED: protein translation factor SUI1 homolog [Fragaria vesca subsp]. vesca] gi|470116354|ref|XP_004294347.1| | 11 | ||
| – | Translation factor Sui1-like protein [Medicago truncatula] gi|357452747|ref|XP_003596650.1| | 11 | ||
| – | Translation factor SUI1; TAIR: AT5G54940.1 Translation initiation factor SUI1 family protein; Swiss-Prot: sp|Q94JV4|SUI12_ARATH Protein translation factor SUI1 homolog 2; TrEMBL-Plants: tr|I3SF96|I3SF96_LOTJA Uncharacterized protein; Found in the gene: LotjaGi1g1v0028800 | 12 | ||
| – | Translation factor SUI1; TAIR: AT5G54940.1 Translation initiation factor SUI1 family protein; Swiss-Prot: sp|Q94JV4|SUI12_ARATH Protein translation factor SUI1 homolog 2; TrEMBL-Plants: tr|I3SF96|I3SF96_LOTJA Uncharacterized protein; Found in the gene: LotjaGi1g1v0028800 | 12 | ||
| – | Translation factor SUI1; TAIR: AT5G54940.1 Translation initiation factor SUI1 family protein; Swiss-Prot: sp|Q94JV4|SUI12_ARATH Protein translation factor SUI1 homolog 2; TrEMBL-Plants: tr|I3SF96|I3SF96_LOTJA Uncharacterized protein; Found in the gene: LotjaGi1g1v0028800 | 12 | ||
| – | Protein translation factor SUI1-like protein; TAIR: AT5G54760.1 Translation initiation factor SUI1 family protein; Swiss-Prot: sp|A6MZM2|SUI1_ORYSI Protein translation factor SUI1 homolog; TrEMBL-Plants: tr|I3T7H3|I3T7H3_LOTJA Uncharacterized protein; Found in the gene: LotjaGi3g1v0149600 | 12 | ||
| – | Protein translation factor SUI1; TAIR: AT4G27130.1 Translation initiation factor SUI1 family protein; Swiss-Prot: sp|O48650|SUI1_SALBA Protein translation factor SUI1 homolog; TrEMBL-Plants: tr|I3S4C1|I3S4C1_LOTJA Uncharacterized protein; Found in the gene: LotjaGi3g1v0236900 | 12 | ||
| – | Protein translation factor SUI1 like; TAIR: AT4G27130.1 Translation initiation factor SUI1 family protein; Swiss-Prot: sp|O48650|SUI1_SALBA Protein translation factor SUI1 homolog; TrEMBL-Plants: tr|A0A151R348|A0A151R348_CAJCA Protein translation factor SUI1 isogeny; Found in the gene: LotjaGi3g1v0464100 | 12 | ||
| – | Protein translation factor SUI1 like; TAIR: AT4G27130.1 Translation initiation factor SUI1 family protein; Swiss-Prot: sp|O48650|SUI1_SALBA Protein translation factor SUI1 homolog; TrEMBL-Plants: tr|A0A151R348|A0A151R348_CAJCA Protein translation factor SUI1 isogeny; Found in the gene: LotjaGi3g1v0464100 | 12 | ||
| – | Translation factor SUI1; TAIR: AT5G54940.1 Translation initiation factor SUI1 family protein; Swiss-Prot: sp|P56330|SUI1_MAIZE Protein translation factor SUI1 homolog; TrEMBL-Plants: tr|V7BN58|V7BN58_PHAVU Uncharacterized protein; Found in the gene: LotjaGi6g1v0159400 | 12 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| cd11566 | CDD | 1 | 9.09 |