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IPR005888 is a dTDP-glucose 4,6-dehydratase.
<p>The conversion of dTDP-glucose into dTDP-4-keto-6-deoxyglucose by Escherichia coli dTDP-glucose 4,6-dehydratase takes place in the active site in three steps: dehydrogenation to dTDP-4-ketoglucose, dehydration to dTDP-4-ketoglucose-5,6-ene, and rereduction of C6 to the methyl group. The 4,6-dehydratase makes use of tightly bound NAD<sup>+</sup>as the coenzyme for transiently oxidizing the substrate, activating it for the dehydration step [[cite:PUB00007907]]. This and other 4,6-dehydratases catalyze the first committed step in all 6-deoxysugar biosynthetic pathways described to date. Numerous 6-deoxysugars are used in bacterial lipopolysaccharide production as well as in the biosynthesis of a diverse array of secondary metabolites.</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | DTDP-glucose 4,6-dehydratase activity | Catalysis of the reaction: dTDP-glucose = dTDP-4-dehydro-6-deoxy-alpha-D-glucose + H(2)O. | ||
| Biological process | Nucleotide-sugar metabolic process | The cellular chemical reactions and pathways involving nucleotide-sugars, any nucleotide-carbohydrate in which the distal phosphoric residue of a nucleoside 5'-diphosphate is in glycosidic linkage with a monosaccharide or monosaccharide derivative. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: probable rhamnose biosynthetic enzyme 1-like [Glycine max] gi|356556634|ref|XP_003546628.1| | 13 | ||
| – | Udp-glucose 4,6-dehydratase; TAIR: AT1G78570.1 rhamnose biosynthesis 1; Swiss-Prot: sp|Q9SYM5|RHM1_ARATH Trifunctional UDP-glucose 4,6-dehydratase/UDP-4-keto-6-deoxy-D-glucose 3,5-epimerase/UDP-4-keto-L-rhamnose-reductase RHM1; TrEMBL-Plants: tr|A0A1J7GF13|A0A1J7GF13_LUPAN Uncharacterized protein; Found in the gene: LotjaGi3g1v0039200 | 13 | ||
| – | Udp-glucose 4,6-dehydratase; TAIR: AT1G78570.1 rhamnose biosynthesis 1; Swiss-Prot: sp|Q9SYM5|RHM1_ARATH Trifunctional UDP-glucose 4,6-dehydratase/UDP-4-keto-6-deoxy-D-glucose 3,5-epimerase/UDP-4-keto-L-rhamnose-reductase RHM1; TrEMBL-Plants: tr|A0A1J7GF13|A0A1J7GF13_LUPAN Uncharacterized protein; Found in the gene: LotjaGi3g1v0039200 | 13 | ||
| – | Udp-glucose 4,6-dehydratase; TAIR: AT1G78570.1 rhamnose biosynthesis 1; Swiss-Prot: sp|Q9SYM5|RHM1_ARATH Trifunctional UDP-glucose 4,6-dehydratase/UDP-4-keto-6-deoxy-D-glucose 3,5-epimerase/UDP-4-keto-L-rhamnose-reductase RHM1; TrEMBL-Plants: tr|A0A1J7GF13|A0A1J7GF13_LUPAN Uncharacterized protein; Found in the gene: LotjaGi3g1v0039300 | 14 | ||
| – | Udp-glucose 4,6-dehydratase; TAIR: AT1G78570.1 rhamnose biosynthesis 1; Swiss-Prot: sp|Q9SYM5|RHM1_ARATH Trifunctional UDP-glucose 4,6-dehydratase/UDP-4-keto-6-deoxy-D-glucose 3,5-epimerase/UDP-4-keto-L-rhamnose-reductase RHM1; TrEMBL-Plants: tr|A0A1J7GF13|A0A1J7GF13_LUPAN Uncharacterized protein; Found in the gene: LotjaGi3g1v0039300 | 14 | ||
| – | Udp-glucose 4,6-dehydratase; TAIR: AT1G78570.1 rhamnose biosynthesis 1; Swiss-Prot: sp|Q9SYM5|RHM1_ARATH Trifunctional UDP-glucose 4,6-dehydratase/UDP-4-keto-6-deoxy-D-glucose 3,5-epimerase/UDP-4-keto-L-rhamnose-reductase RHM1; TrEMBL-Plants: tr|A0A1J7GF13|A0A1J7GF13_LUPAN Uncharacterized protein; Found in the gene: LotjaGi3g1v0039300 | 14 | ||
| – | Udp-glucose 4,6-dehydratase; TAIR: AT1G78570.1 rhamnose biosynthesis 1; Swiss-Prot: sp|Q9SYM5|RHM1_ARATH Trifunctional UDP-glucose 4,6-dehydratase/UDP-4-keto-6-deoxy-D-glucose 3,5-epimerase/UDP-4-keto-L-rhamnose-reductase RHM1; TrEMBL-Plants: tr|A0A1J7GF13|A0A1J7GF13_LUPAN Uncharacterized protein; Found in the gene: LotjaGi3g1v0039300 | 14 | ||
| – | Udp-glucose 4,6-dehydratase; TAIR: AT1G78570.1 rhamnose biosynthesis 1; Swiss-Prot: sp|Q9SYM5|RHM1_ARATH Trifunctional UDP-glucose 4,6-dehydratase/UDP-4-keto-6-deoxy-D-glucose 3,5-epimerase/UDP-4-keto-L-rhamnose-reductase RHM1; TrEMBL-Plants: tr|I1M9T9|I1M9T9_SOYBN Uncharacterized protein; Found in the gene: LotjaGi5g1v0066900 | 13 | ||
| – | Udp-glucose 4,6-dehydratase; TAIR: AT1G78570.1 rhamnose biosynthesis 1; Swiss-Prot: sp|Q9SYM5|RHM1_ARATH Trifunctional UDP-glucose 4,6-dehydratase/UDP-4-keto-6-deoxy-D-glucose 3,5-epimerase/UDP-4-keto-L-rhamnose-reductase RHM1; TrEMBL-Plants: tr|I1M9T9|I1M9T9_SOYBN Uncharacterized protein; Found in the gene: LotjaGi5g1v0066900 | 13 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| cd05254 | CDD | 1 | 11.11 |