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IPR006205

Source: InterPro

Description

IPR006205 is a Mevalonate kinase.

<p>Mevalonate kinase is well-characterised among eukaryotes, where it plays a role in the synthesis of isopentanyl pyrophosphate, a common intermediate for a number of pathways including cholesterol biosynthesis. It is also involved in mevalonate catabolism [[cite:PUB00100288], [cite:PUB00049240], [cite:PUB00100293], [cite:PUB00100292]]. Close homologues are found in archaea. Related bacterial proteins are also included in this entry.</p>

This description is obtained from EB-eye REST.

Associated GO terms

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .

GO term Namespace Name Definition Relationships
GO:0004496
Molecular function Mevalonate kinase activity Catalysis of the reaction: (R)-mevalonate + ATP = (R)-5-phosphomevalonate + ADP + 2 H(+).
Subterm of
GO:0005524
Molecular function ATP binding Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
Subterm of
GO:0005737
Cellular component Cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
Subterm of
GO:0008299
Biological process Isoprenoid biosynthetic process The chemical reactions and pathways resulting in the formation of any isoprenoid compound, isoprene (2-methylbuta-1,3-diene) or compounds containing or derived from linked isoprene (3-methyl-2-butenylene) residues.
Subterm of

Associated Lotus transcripts 2

Transcript Name Description Predicted domains Domain count
Lj1g3v4942840.1
– PREDICTED: mevalonate kinase-like [Glycine max] gi|356505870|ref|XP_003521712.1|
Domains
13
Lj1g3v4943880.1
– PREDICTED: mevalonate kinase-like [Glycine max] gi|356505870|ref|XP_003521712.1|
Domains
18

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space:

Predicted domain Source Observations Saturation (%)
TIGR00549 TIGRFAM 1 50.00