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IPR006298 is a GTP-binding protein BipA.
<p>This family includes the GTP-binding protein BipA or TypA (Tyrosine phosphorylated protein A (TypA), also known as 50S ribosomal subunit assembly factor BipA) from bacteria and its homologue from Arabidopsis (putative elongation factor TypA-like SVR3). BipA is a 50S ribosomal subunit assembly protein with GTPase activity, required for 50S subunit assembly at low temperatures, also functions as a translation factor that is required specifically for the expression of the transcriptional modulator Fis. BipA binds the 70S ribosome at a site that coincides with that of EF-G and has a GTPase activity that is sensitive to high GDP:GTP ratios and is stimulated by 70S ribosomes programmed with mRNA and aminoacylated tRNAs [[cite:PUB00101695], [cite:PUB00101694]]. The growth rate-dependent induction of BipA allows the efficient expression of Fis, thereby modulating a range of downstream processes, including DNA metabolism and type III secretion. This GTPase impacts interactions between enteropathogenic E.coli (EPEC) and epithelial cells and also has an effect on motility [[cite:PUB00043024]]. It appears to be involved in the regulation of several processes important for infection, including rearrangements of the cytoskeleton of the host, bacterial resistance to host defence peptides, flagellum-mediated cell motility, and expression of K5 capsular genes [[cite:PUB00085803], [cite:PUB00092580]].</p> <p>TypA-like SVR3 is a putative chloroplastic elongation factor involved in response to chilling stress. It is required for proper chloroplast rRNA processing and/or translation at low temperature [[cite:PUB00101692]] and it is also involved in plastid protein homeostasis [[cite:PUB00101693]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | GTP binding | Interacting selectively and non-covalently with GTP, guanosine triphosphate. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: GTP-binding protein TypA/BipA homolog [Cicer arietinum] gi|502143941|ref|XP_004505523.1| | 36 | ||
| – | PREDICTED: GTP-binding protein TypA/BipA homolog [Glycine max] gi|356500497|ref|XP_003519068.1| | 32 | ||
| – | Elongation factor 4; TAIR: AT5G13650.1 elongation factor family protein; Swiss-Prot: sp|P72749|TYPA_SYNY3 GTP-binding protein TypA/BipA homolog; TrEMBL-Plants: tr|A0A0L9TVK2|A0A0L9TVK2_PHAAN Uncharacterized protein; Found in the gene: LotjaGi0g1v0000300 | 35 | ||
| – | Elongation factor 4; TAIR: AT2G31060.2 elongation factor family protein; Swiss-Prot: sp|O25225|TYPA_HELPY GTP-binding protein TypA/BipA homolog; TrEMBL-Plants: tr|A0A0S3SB66|A0A0S3SB66_PHAAN Uncharacterized protein; Found in the gene: LotjaGi3g1v0244900 | 39 | ||
| – | Elongation factor G; TAIR: AT2G31060.1 elongation factor family protein; Swiss-Prot: sp|O25225|TYPA_HELPY GTP-binding protein TypA/BipA homolog; TrEMBL-Plants: tr|A0A151TP89|A0A151TP89_CAJCA GTP-binding protein TypA/BipA isogeny; Found in the gene: LotjaGi3g1v0244900 | 15 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| cd16263 | CDD | 1 | 20.00 |