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IPR007504 is a H/ACA ribonucleoprotein complex, subunit Gar1/Naf1.
<p>H/ACA ribonucleoprotein particles (RNPs) are a family of RNA pseudouridine synthases that specify modification sites through guide RNAs. The function of these H/ACA RNPs is essential for biogenesis of the ribosome, splicing of precursor mRNAs (pre-mRNAs), maintenance of telomeres and probably for additional cellular processes [[cite:PUB00053435]]. All H/ACA RNPs contain a specific RNA component (snoRNA or scaRNA) and at least four proteins common to all such particles: Cbf5, Gar1, Nhp2 and Nop10. These proteins are highly conserved from yeast to mammals and homologues are also present in archaea [[cite:PUB00088317]]. The H/ACA protein complex contains a stable core composed of Cbf5 and Nop10, to which Gar1 and Nhp2 subsequently bind [[cite:PUB00053436]].</p> <p>Naf1 is an RNA-binding protein required for the maturation of box H/ACA snoRNPs complex and ribosome biogenesis. During assembly of the H/ACA snoRNPs complex, it associates with the complex, disappearing during maturation of the complex and being replaced by Gar1 to yield mature H/ACA snoRNPs complex. The core domain of Naf1 is homologous to the core domain of Gar1, suggesting that they share a common Cbf5 binding surface [[cite:PUB00049556]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Biological process | Pseudouridine synthesis | The intramolecular conversion of uridine to pseudouridine within an RNA molecule. This posttranscriptional base modification occurs in tRNA, rRNA, and snRNAs. | ||
| Biological process | Ribosome biogenesis | A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of ribosome subunits; includes transport to the sites of protein synthesis. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | H/ACA ribonucleoprotein complex non-core subunit NAF1 [Medicago truncatula] gi|358345105|ref|XP_003636623.1| | 6 | ||
| – | H/ACA ribonucleoprotein complex subunit 1-like protein 1 [Theobroma cacao] gi|508719325|gb|EOY11222.1| | 9 | ||
| – | PREDICTED: H/ACA ribonucleoprotein complex non-core subunit NAF1-like [Cicer arietinum] gi|502082945|ref|XP_004487320.1| | 7 | ||
| – | H/ACA ribonucleoprotein complex subunit 1-like protein 1; TAIR: AT3G03920.1 H/ACA ribonucleoprotein complex, subunit Gar1/Naf1 protein; Swiss-Prot: sp|Q8VZT0|NLAL1_ARATH Putative H/ACA ribonucleoprotein complex subunit 1-like protein 1; TrEMBL-Plants: tr|A0A072U1E4|A0A072U1E4_MEDTR Gar1/Naf1 RNA-binding region protein; Found in the gene: LotjaGi1g1v0642700_LC | 9 | ||
| – | H/ACA ribonucleoprotein complex subunit 1-like protein 1; TAIR: AT3G03920.1 H/ACA ribonucleoprotein complex, subunit Gar1/Naf1 protein; Swiss-Prot: sp|Q8VZT0|NLAL1_ARATH Putative H/ACA ribonucleoprotein complex subunit 1-like protein 1; TrEMBL-Plants: tr|A0A072U1E4|A0A072U1E4_MEDTR Gar1/Naf1 RNA-binding region protein; Found in the gene: LotjaGi1g1v0642700_LC | 9 | ||
| – | H/ACA ribonucleoprotein complex non-core subunit NAF1; TAIR: AT1G03530.1 nuclear assembly factor 1; Swiss-Prot: sp|Q96HR8|NAF1_HUMAN H/ACA ribonucleoprotein complex non-core subunit NAF1; TrEMBL-Plants: tr|A0A1J7HBW8|A0A1J7HBW8_LUPAN Uncharacterized protein; Found in the gene: LotjaGi3g1v0441300 | 9 | ||
| – | H/ACA ribonucleoprotein complex non-core subunit NAF1; TAIR: AT1G03530.1 nuclear assembly factor 1; Swiss-Prot: sp|Q96HR8|NAF1_HUMAN H/ACA ribonucleoprotein complex non-core subunit NAF1; TrEMBL-Plants: tr|K7LU49|K7LU49_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0458700 | 9 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| mobidb-lite | MobiDBLite | 1 | 14.29 |