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IPR040309 is a H/ACA ribonucleoprotein complex non-core subunit Naf1.
<p>Naf1 is an RNA-binding protein required for the maturation of box H/ACA snoRNPs complex and ribosome biogenesis. During assembly of the H/ACA snoRNPs complex, it associates with the complex, disappearing during maturation of the complex and being replaced by Gar1 to yield mature H/ACA snoRNPs complex. The core domain of Naf1 is homologous to the core domain of Gar1, suggesting that they share a common Cbf5 binding surface [[cite:PUB00049556]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Biological process | Box H/ACA snoRNP assembly | The aggregation, arrangement and bonding together of proteins and a box H/ACA snoRNA to form a box H/ACA small nucleolar ribonucleoprotein (snoRNP) complex. | ||
| Molecular function | RNA binding | Interacting selectively and non-covalently with an RNA molecule or a portion thereof. | ||
| Cellular component | Small nucleolar ribonucleoprotein complex | A ribonucleoprotein complex that contains an RNA molecule of the small nucleolar RNA (snoRNA) family and associated proteins. Most are involved in a step of processing of rRNA: cleavage, 2'-O-methylation, or pseudouridylation. The majority, though not all, fall into one of two classes, box C/D type or box H/ACA type. | ||
| Biological process | Ribosome biogenesis | A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of ribosome subunits; includes transport to the sites of protein synthesis. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | H/ACA ribonucleoprotein complex non-core subunit NAF1; TAIR: AT1G03530.1 nuclear assembly factor 1; Swiss-Prot: sp|Q96HR8|NAF1_HUMAN H/ACA ribonucleoprotein complex non-core subunit NAF1; TrEMBL-Plants: tr|A0A1J7HBW8|A0A1J7HBW8_LUPAN Uncharacterized protein; Found in the gene: LotjaGi3g1v0441300 | 9 | ||
| – | H/ACA ribonucleoprotein complex non-core subunit NAF1; TAIR: AT1G03530.1 nuclear assembly factor 1; Swiss-Prot: sp|Q96HR8|NAF1_HUMAN H/ACA ribonucleoprotein complex non-core subunit NAF1; TrEMBL-Plants: tr|K7LU49|K7LU49_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0458700 | 9 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| mobidb-lite | MobiDBLite | 1 | 50.00 |