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IPR007726 is a SS18, N-terminal.
<p>This entry represents the N-terminal domain of SS18 and related proteins.</p> <p>SSXT (also known as SS18) appears to function synergistically with RBM14 as a transcriptional coactivator [[cite:PUB00053835]].</p> <p>The SSXT protein is involved in synovial sarcoma in humans. A SYT-SSX fusion gene resulting from the chromosomal translocation t(X;18) (p11;q11) is characteristic of synovial sarcomas. This translocation fuses the SSXT (SYT) gene from chromosome 18 to either of two homologous genes at Xp11, SSX1 or SSX2 [[cite:PUB00010223]].</p> <p>The SS18 family also includes SS18-like proteins 1 and 2, and GRF1-interacting factors from plants [[cite:PUB00068030]]. SS18-like protein 1 is a transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons [[cite:PUB00053836], [cite:PUB00053837]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | Transcription coactivator activity | A protein or a member of a complex that interacts specifically and non-covalently with a DNA-bound DNA-binding transcription factor to activate the transcription of specific genes. Coactivators often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second ATP-dependent class modifies the conformation of chromatin. Another type of coregulator activity is the bridging of a DNA-binding transcription factor to the basal transcription machinery. The Mediator complex, which bridges transcription factors and RNA polymerase, is also a transcription coactivator. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | SSXT family protein isoform 1 [Theobroma cacao] gi|508719100|gb|EOY10997.1| | 6 | ||
| – | Calcium-responsive transactivator [Medicago truncatula] gi|357441437|ref|XP_003590996.1| | 4 | ||
| – | PREDICTED: GRF1-interacting factor 3-like isoform X1 [Cicer arietinum] gi|502136557|ref|XP_004502728.1| | 3 | ||
| – | PREDICTED: GRF1-interacting factor 3-like [Cicer arietinum] gi|502156743|ref|XP_004510625.1| | 4 | ||
| – | PREDICTED: GRF1-interacting factor 3-like [Cicer arietinum] gi|502156743|ref|XP_004510625.1| | 3 | ||
| – | SSXT family protein isoform 1 [Theobroma cacao] gi|508719100|gb|EOY10997.1| | 5 | ||
| – | GRF1-interacting factor-like protein; TAIR: AT4G00850.1 GRF1-interacting factor 3; Swiss-Prot: sp|Q93VH6|GIF3_ARATH GRF1-interacting factor 3; TrEMBL-Plants: tr|A0A151RS37|A0A151RS37_CAJCA SS18-like protein 2; Found in the gene: LotjaGi1g1v0294500 | 5 | ||
| – | GRF1-interacting factor-like protein; TAIR: AT5G28640.1 SSXT family protein; Swiss-Prot: sp|Q8L8A5|GIF1_ARATH GRF1-interacting factor 1; TrEMBL-Plants: tr|I3S8D8|I3S8D8_LOTJA Uncharacterized protein; Found in the gene: LotjaGi1g1v0783300 | 5 | ||
| – | GRF1-interacting factor-like protein; TAIR: AT4G00850.1 GRF1-interacting factor 3; Swiss-Prot: sp|Q93VH6|GIF3_ARATH GRF1-interacting factor 3; TrEMBL-Plants: tr|I3T6C4|I3T6C4_LOTJA Uncharacterized protein; Found in the gene: LotjaGi3g1v0401600 | 5 | ||
| – | GRF1-interacting factor-like protein; TAIR: AT4G00850.1 GRF1-interacting factor 3; Swiss-Prot: sp|Q93VH6|GIF3_ARATH GRF1-interacting factor 3; TrEMBL-Plants: tr|I3T6C4|I3T6C4_LOTJA Uncharacterized protein; Found in the gene: LotjaGi3g1v0401600 | 5 | ||
| – | GRF1-interacting factor-like protein; TAIR: AT4G00850.1 GRF1-interacting factor 3; Swiss-Prot: sp|Q93VH6|GIF3_ARATH GRF1-interacting factor 3; TrEMBL-Plants: tr|I3T6C4|I3T6C4_LOTJA Uncharacterized protein; Found in the gene: LotjaGi3g1v0401600 | 5 | ||
| – | GRF1-interacting factor-like protein; TAIR: AT5G28640.1 SSXT family protein; Swiss-Prot: sp|Q8L8A5|GIF1_ARATH GRF1-interacting factor 1; TrEMBL-Plants: tr|I1LBN5|I1LBN5_SOYBN Uncharacterized protein; Found in the gene: LotjaGi5g1v0210700 | 6 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| mobidb-lite | MobiDBLite | 1 | 8.33 |