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IPR008048 is a DNA replication licensing factor Mcm5.
<p>The MCM2-7 complex consists of six closely related proteins that are highly conserved throughout the eukaryotic kingdom. In eukaryotes, Mcm5 is a component of the MCM2-7 complex (MCM complex), which consists of six sequence-related AAA + type ATPases/helicases that form a hetero-hexameric ring [[cite:PUB00063047]]. MCM2-7 complex is part of the pre-replication complex (pre-RC). In G1 phase, inactive MCM2-7 complex is loaded onto origins of DNA replication [[cite:PUB00063043], [cite:PUB00063044], [cite:PUB00063046]]. During G1-S phase, MCM2-7 complex is activated to unwind the double stranded DNA and plays an important role in DNA replication forks elongation [[cite:PUB00063046]].</p> <p>The components of the MCM2-7 complex are:</p> <ul> <li> DNA replication licensing factor MCM2, [interpro:IPR008045]</li> <li> DNA replication licensing factor MCM3, [interpro:IPR008046]</li> <li> DNA replication licensing factor MCM4, [interpro:IPR008047]</li> <li> DNA replication licensing factor MCM5, [interpro:IPR008048]</li> <li> DNA replication licensing factor MCM6, [interpro:IPR008049]</li> <li> DNA replication licensing factor MCM7, [interpro:IPR008050]</li> </ul>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | DNA replication origin binding | Interacting selectively and non-covalently with the DNA replication origin, a unique DNA sequence of a replicon at which DNA replication is initiated and proceeds bidirectionally or unidirectionally. | ||
| Molecular function | ATP binding | Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. | ||
| Cellular component | Nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. | ||
| Biological process | DNA replication initiation | The process in which DNA-dependent DNA replication is started; this begins with the ATP dependent loading of an initiator complex onto the DNA, this is followed by DNA melting and helicase activity. In bacteria, the gene products that enable the helicase activity are loaded after the initial melting and in archaea and eukaryotes, the gene products that enable the helicase activity are inactive when they are loaded and subsequently activate. | ||
| Cellular component | MCM complex | A hexameric protein complex required for the initiation and regulation of DNA replication. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: DNA replication licensing factor mcm5-A-like [Cicer arietinum] gi|502151329|ref|XP_004508387.1| | 23 | ||
| – | PREDICTED: DNA replication licensing factor mcm5-A-like [Glycine max] gi|356562886|ref|XP_003549699.1| | 16 | ||
| – | DNA helicase; TAIR: AT2G07690.1 Minichromosome maintenance (MCM2/3/5) family protein; Swiss-Prot: sp|O80786|MCM5_ARATH DNA replication licensing factor MCM5; TrEMBL-Plants: tr|B3GNI3|B3GNI3_PEA DNA helicase; Found in the gene: LotjaGi4g1v0283800 | 28 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| cd17756 | CDD | 1 | 33.33 |