Your browser is unable to support new features implemented in HTML5 and CSS3 to render this site as intended. Your experience may suffer from functionality degradation but the site should remain usable. We strongly recommend the latest version of Google Chrome, OS X Safari or Mozilla Firefox. As Safari is bundled with OS X, if you are unable to upgrade to a newer version of OS X, we recommend using an open source browser. Dismiss message

IPR008221

Description

IPR008221 is a Urease.

<p>Urease (urea amidohydrolase, [ec:3.5.1.5]) catalyses the hydrolysis of urea to form ammonia and carbamate. The subunit composition of urease from different sources varies [[cite:PUB00010725]], but each holoenzyme consists of four structural domains [[cite:PUB00005206]]: three structural domains and a nickel-binding catalytic domain common to amidohydrolases [[cite:PUB00004994]]. Urease is unique among nickel metalloenzymes in that it catalyses a hydrolysis rather than a redox reaction. In Klebsiella aerogenes, the domains are found in an alpha subunit (with the C-terminal two-thirds representing the catalytic domain and the N-terminal one-third representing one of the structural domains); a beta subunit, and a gamma subunit. In Helicobacter pylori, the gamma and beta domains are fused and called the alpha subunit. The catalytic subunit (called beta or B) has the same organisation as the K. aerogenes alpha subunit. Jack bean (Canavalia ensiformis) urease has a fused gamma-beta-alpha organisation.</p> <p>This group represents the gamma-beta-alpha type.</p>

This description is obtained from EB-eye REST.

Associated GO terms

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .

GO term Namespace Name Definition Relationships
Biological process Nitrogen compound metabolic process The chemical reactions and pathways involving organic or inorganic compounds that contain nitrogen.
Molecular function Urease activity Catalysis of the reaction: urea + H2O = CO2 + 2 NH3.
Molecular function Nickel cation binding Interacting selectively and non-covalently with nickel (Ni) cations.

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space:

Predicted domain Source Observations Saturation (%)
cd00407 CDD 1 100.00