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IPR005848 is a Urease, alpha subunit.
<p>Urease (urea amidohydrolase, [ec:3.5.1.5]) is a nickel-binding enzyme that catalyses the hydrolysis of urea to form ammonia and carbamate [[cite:PUB00001363]]. It is mainly found in plant seeds, microorganisms and invertebrates. In plants, urease is a hexamer of identical chains, but the subunit composition of urease from different sources varies [[cite:PUB00010725]], in bacteria [[cite:PUB00003605]] it consists of either two or three different subunits (alpha, beta and gamma).</p> <p>Urease binds two nickel ions per subunit; four histidine, an aspartate and a carbamated-lysine serve as ligands to these metals; an additional histidine is involved in the catalytic mechanism [[cite:PUB00005206]]. The urease domain forms an (alpha β)(8) barrel structure with structural similarity to other metal-dependent hydrolases, such as adenosine and AMP deaminase and phosphotriesterase. Urease is unique among nickel metalloenzymes in that it catalyses a hydrolysis rather than a redox reaction.</p> <p>The orthologous protein is known as the alpha subunit (ureC) in most other bacteria.In Helicobacter pylori, the gamma and beta domains are fused and called the alpha subunit ([interpro:IPR008223]). The catalytic subunit (called beta or B) has the same organisation as the Klebsiella alpha subunit. Jack bean (Canavalia ensiformis) urease has a fused gamma-beta-alpha organisation ([interpro:IPR008221]). This entry describes the urease alpha subunit UreC (designated beta or B chain, UreB in Helicobacter species).</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Biological process | Nitrogen compound metabolic process | The chemical reactions and pathways involving organic or inorganic compounds that contain nitrogen. | ||
| Molecular function | Urease activity | Catalysis of the reaction: urea + H2O = CO2 + 2 NH3. | ||
| Molecular function | Nickel cation binding | Interacting selectively and non-covalently with nickel (Ni) cations. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: urease-like [Cicer arietinum] gi|502135386|ref|XP_004502315.1| | 34 | ||
| – | Urease subunit alpha; TAIR: AT1G67550.1 urease; Swiss-Prot: sp|P07374|UREA_CANEN Urease; TrEMBL-Plants: tr|Q949H4|Q949H4_SOYBN Urease; Found in the gene: LotjaGi6g1v0101300 | 38 | ||
| – | Urease subunit alpha; TAIR: AT1G67550.1 urease; Swiss-Prot: sp|P07374|UREA_CANEN Urease; TrEMBL-Plants: tr|Q949H4|Q949H4_SOYBN Urease; Found in the gene: LotjaGi6g1v0101300 | 33 | ||
| – | Urease subunit alpha; TAIR: AT1G67550.1 urease; Swiss-Prot: sp|P07374|UREA_CANEN Urease; TrEMBL-Plants: tr|Q949H4|Q949H4_SOYBN Urease; Found in the gene: LotjaGi6g1v0101300 | 29 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| cd00407 | CDD | 1 | 25.00 |