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IPR011612 is a Urease alpha-subunit, N-terminal domain.
<p>Urease (urea amidohydrolase, [ec:3.5.1.5]) catalyses the hydrolysis of urea to form ammonia and carbamate. The subunit composition of urease from different sources varies [[cite:PUB00010725]], but each holoenzyme consists of four structural domains [[cite:PUB00005206]]: three structural domains and a nickel-binding catalytic domain common to amidohydrolases [[cite:PUB00004994]]. Urease is unique among nickel metalloenzymes in that it catalyses a hydrolysis rather than a redox reaction. In Helicobacter pylori, the gamma and beta domains are fused and called the alpha subunit ([interpro:IPR008223]). The catalytic subunit (called beta or B) has the same organisation as the Klebsiella alpha subunit. Jack bean (Canavalia ensiformis) urease has a fused gamma-beta-alpha organisation ([interpro:IPR008221]).</p> <p>The N-terminal domain is a composite domain and plays a major trimer stabilising role by contacting the catalytic domain of the symmetry related alpha-subunit [[cite:PUB00005206]].</p>
This description is obtained from EB-eye REST.
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: urease-like [Cicer arietinum] gi|502135386|ref|XP_004502315.1| | 34 | ||
| – | Urease subunit alpha; TAIR: AT1G67550.1 urease; Swiss-Prot: sp|P07374|UREA_CANEN Urease; TrEMBL-Plants: tr|Q949H4|Q949H4_SOYBN Urease; Found in the gene: LotjaGi6g1v0101300 | 38 | ||
| – | Urease subunit alpha; TAIR: AT1G67550.1 urease; Swiss-Prot: sp|P07374|UREA_CANEN Urease; TrEMBL-Plants: tr|Q949H4|Q949H4_SOYBN Urease; Found in the gene: LotjaGi6g1v0101300 | 33 | ||
| – | Urease subunit alpha; TAIR: AT1G67550.1 urease; Swiss-Prot: sp|P07374|UREA_CANEN Urease; TrEMBL-Plants: tr|Q949H4|Q949H4_SOYBN Urease; Found in the gene: LotjaGi6g1v0101300 | 29 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| cd00407 | CDD | 1 | 25.00 |