Your browser is unable to support new features implemented in HTML5 and CSS3 to render this site as intended. Your experience may suffer from functionality degradation but the site should remain usable. We strongly recommend the latest version of Google Chrome, OS X Safari or Mozilla Firefox. As Safari is bundled with OS X, if you are unable to upgrade to a newer version of OS X, we recommend using an open source browser. Dismiss message

IPR011059

Description

IPR011059 is a Metal-dependent hydrolase, composite domain superfamily.

<p>The composite domain of metal-dependent hydrolases has a pseudo-barrel fold that is interrupted by the catalytic β/α barrel domain. This domain is found in a variety of bacterial and fungal enzymes, including: cytosine deaminase, an enzyme that is important in the pyrimidine salvage pathway [[cite:PUB00014255]]; the alpha-subunit of urease, a virulence factor of gastric pathogens such as Helicobacter pylori (Campylobacter pylori) [[cite:PUB00014256]]; D- and L-hydantoinases (dihydropyrimidinase), which catalyse the production of D- and L-amino acids, respectively [[cite:PUB00014257]]; isoaspartyl dipeptidase from Escherichia coli, which functions in protein degradation [[cite:PUB00014258]]; N-acetylglucosamine-6-phosphate deacetylase, which is an enzyme from the biosynthetic pathway to amino-sugar-nucleotides [[cite:PUB00014260]]; and N-acyl-D-amino acid amidohydrolase (D-aminoacylase), involved in the synthesis of D-amino acids [[cite:PUB00014261]].</p>

This description is obtained from EB-eye REST.

Associated GO terms

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .

GO term Namespace Name Definition Relationships
Molecular function Hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds Catalysis of the hydrolysis of any carbon-nitrogen bond, C-N, with the exception of peptide bonds.

Associated Lotus transcripts 25

Transcript Name Description Predicted domains Domain count
LAF3 isoform [Medicago truncatula] gi|357456493|ref|XP_003598527.1| 11
LAF3 isoform [Medicago truncatula] gi|357456493|ref|XP_003598527.1| 18
Amidohydrolase family, ISF2 isoform 2 [Theobroma cacao] gi|508727884|gb|EOY19781.1| 9
PREDICTED: 5-methylthioadenosine/S-adenosylhomocysteine deaminase-like isoform X1 [Cicer arietinum] gi|502121742|ref|XP_004497426.1| 14
PREDICTED: 5-methylthioadenosine/S-adenosylhomocysteine deaminase-like isoform X1 [Cicer arietinum] gi|502121742|ref|XP_004497426.1| 11
PREDICTED: urease-like [Cicer arietinum] gi|502135386|ref|XP_004502315.1| 34
PREDICTED: dihydropyrimidinase-like isoform X1 [Cicer arietinum] gi|502098432|ref|XP_004491233.1| 17
PREDICTED: dihydropyrimidinase-like isoform X1 [Cicer arietinum] gi|502098432|ref|XP_004491233.1| 18
PREDICTED: dihydropyrimidinase-like isoform X1 [Cicer arietinum] gi|502098432|ref|XP_004491233.1| 23
Allantoinase [Robinia pseudoacacia] gi|39653353|gb|AAR29343.1| 19
Allantoinase [Robinia pseudoacacia] gi|39653353|gb|AAR29343.1| 14
Dihydropyrimidinase; TAIR: AT5G12200.1 pyrimidine 2; Swiss-Prot: sp|Q9FMP3|DPYS_ARATH Dihydropyrimidinase; TrEMBL-Plants: tr|G7K315|G7K315_MEDTR Dihydropyrimidinase; Found in the gene: LotjaGi1g1v0051700 20
Dihydropyrimidinase; TAIR: AT5G12200.1 pyrimidine 2; Swiss-Prot: sp|Q9FMP3|DPYS_ARATH Dihydropyrimidinase; TrEMBL-Plants: tr|G7K315|G7K315_MEDTR Dihydropyrimidinase; Found in the gene: LotjaGi1g1v0051700 20
Dihydropyrimidinase; TAIR: AT5G12200.1 pyrimidine 2; Swiss-Prot: sp|Q9FMP3|DPYS_ARATH Dihydropyrimidinase; TrEMBL-Plants: tr|A0A151T7P5|A0A151T7P5_CAJCA Dihydropyrimidinase; Found in the gene: LotjaGi1g1v0051700 13
Dihydropyrimidinase; TAIR: AT5G12200.1 pyrimidine 2; Swiss-Prot: sp|Q9FMP3|DPYS_ARATH Dihydropyrimidinase; TrEMBL-Plants: tr|A0A151T7P5|A0A151T7P5_CAJCA Dihydropyrimidinase; Found in the gene: LotjaGi1g1v0051700 13
Dihydropyrimidinase; TAIR: AT5G12200.1 pyrimidine 2; Swiss-Prot: sp|Q9FMP3|DPYS_ARATH Dihydropyrimidinase; TrEMBL-Plants: tr|G7K315|G7K315_MEDTR Dihydropyrimidinase; Found in the gene: LotjaGi1g1v0051700 13
Dihydropyrimidinase; TAIR: AT5G12200.1 pyrimidine 2; Swiss-Prot: sp|Q9FMP3|DPYS_ARATH Dihydropyrimidinase; TrEMBL-Plants: tr|A0A151T7P5|A0A151T7P5_CAJCA Dihydropyrimidinase; Found in the gene: LotjaGi1g1v0051700 13
Dihydropyrimidinase; TAIR: AT5G12200.1 pyrimidine 2; Swiss-Prot: sp|Q9FMP3|DPYS_ARATH Dihydropyrimidinase; TrEMBL-Plants: tr|G7KCW0|G7KCW0_MEDTR Dihydropyrimidinase; Found in the gene: LotjaGi1g1v0051800 19
Phosphomethylpyrimidine synthase; TAIR: AT3G55850.1 Amidohydrolase family; Swiss-Prot: sp|O34355|YTCJ_BACSU Putative amidohydrolase YtcJ; TrEMBL-Plants: tr|K7M0Q9|K7M0Q9_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0318200 12
Amidohydrolase family; TAIR: AT3G55850.5 Amidohydrolase family; Swiss-Prot: sp|O34355|YTCJ_BACSU Putative amidohydrolase YtcJ; TrEMBL-Plants: tr|K7M0Q9|K7M0Q9_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0318200 19
5-methylthioadenosine/S-adenosylhomocysteine deaminase; TAIR: AT3G55850.3 Amidohydrolase family; Swiss-Prot: sp|A5UMN6|DADD_METS3 5'-deoxyadenosine deaminase; TrEMBL-Plants: tr|I1NJF1|I1NJF1_SOYBN Uncharacterized protein; Found in the gene: LotjaGi5g1v0331900 11
Urease subunit alpha; TAIR: AT1G67550.1 urease; Swiss-Prot: sp|P07374|UREA_CANEN Urease; TrEMBL-Plants: tr|Q949H4|Q949H4_SOYBN Urease; Found in the gene: LotjaGi6g1v0101300 38
Urease subunit alpha; TAIR: AT1G67550.1 urease; Swiss-Prot: sp|P07374|UREA_CANEN Urease; TrEMBL-Plants: tr|Q949H4|Q949H4_SOYBN Urease; Found in the gene: LotjaGi6g1v0101300 33
Urease subunit alpha; TAIR: AT1G67550.1 urease; Swiss-Prot: sp|P07374|UREA_CANEN Urease; TrEMBL-Plants: tr|Q949H4|Q949H4_SOYBN Urease; Found in the gene: LotjaGi6g1v0101300 29
Allantoinase; TAIR: AT4G04955.1 allantoinase; Swiss-Prot: sp|Q94AP0|ALN_ARATH Allantoinase; TrEMBL-Plants: tr|Q6S4R9|Q6S4R9_ROBPS Allantoinase; Found in the gene: LotjaGi6g1v0333200 15

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space:

Predicted domain Source Observations Saturation (%)
TRANSMEMBRANE Phobius 1 4.00