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IPR036461 is a Urease, beta subunit superfamily.
<p>Urease is a nickel-dependent metalloenzyme that catalyses the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of external and internally-generated urea as a nitrogen source. The enzyme consists of three subunits, alpha, beta and gamma, which can exist as separate proteins or can be fused on a single protein chain. The α-β-γ heterotrimer forms multimers, mainly trimers. The large alpha subunit is the catalytic domain containing an active site with a bi-nickel centre complexed by a carbamylated lysine. The beta and gamma subunits play a role in subunit association to form the higher order trimers [[cite:PUB00079461], [cite:PUB00018934], [cite:PUB00079462], [cite:PUB00018936], [cite:PUB00010725]].</p> <p>This entry represents the urease beta subunit superfamily. In Helicobacter pylori, the gamma and beta subunits are fused and known (confusingly) as the alpha subunit.</p> <p>The urease beta subunit structure is composed of double-stranded ribbon sharply bent in two places where the ribbon ends form incomplete barrel and has a jelly-roll.</p>
This description is obtained from EB-eye REST.
Transcript | Name | Description | Predicted domains | Domain count |
---|---|---|---|---|
– | Urease subunit alpha; TAIR: AT1G67550.1 urease; Swiss-Prot: sp|P07374|UREA_CANEN Urease; TrEMBL-Plants: tr|Q949H4|Q949H4_SOYBN Urease; Found in the gene: LotjaGi6g1v0101300 | 38 | ||
– | Urease subunit alpha; TAIR: AT1G67550.1 urease; Swiss-Prot: sp|P07374|UREA_CANEN Urease; TrEMBL-Plants: tr|Q949H4|Q949H4_SOYBN Urease; Found in the gene: LotjaGi6g1v0101300 | 33 | ||
– | Urease subunit alpha; TAIR: AT1G67550.1 urease; Swiss-Prot: sp|P07374|UREA_CANEN Urease; TrEMBL-Plants: tr|Q949H4|Q949H4_SOYBN Urease; Found in the gene: LotjaGi6g1v0101300 | 29 |
A list of co-occurring predicted domains within the L. japonicus gene space:
Predicted domain | Source | Observations | Saturation (%) |
---|---|---|---|
cd00407 | CDD | 1 | 33.33 |