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IPR009012

Source: InterPro

Description

IPR009012 is a GrpE nucleotide exchange factor, head.

<p>In prokaryotes, the nucleotide exchange factor GrpE and the chaperone DnaJ are required for nucleotide binding of the molecular chaperone DnaK [[cite:PUB00005226]]. The DnaK reaction cycle involves rapid peptide binding and release, which is dependent upon nucleotide binding. DnaJ accelerates the hydrolysis of ATP by DnaK, which enables the ADP-bound DnaK to tightly bind peptide. GrpE catalyses the release of ADP from DnaK, which is required for peptide release. In eukaryotes, GrpE is essential for mitochondrial Hsp70 function, however the cytosolic Hsp70 homologues are GrpE-independent.</p> <p>GrpE binds as a homodimer to the ATPase domain of DnaK, and may interact with the peptide-binding domain of DnaK. GrpE accomplishes nucleotide exchange by opening the nucleotide-binding cleft of DnaK. GrpE is comprised of two domains, the N-terminal coiled coil domain, which may facilitate peptide release, and the C-terminal head domain, which forms part of the contact surface with the ATPase domain of DnaK. The head domain is comprised of six short β strands with a limited hydrophobic core.</p>

This description is obtained from EB-eye REST.

Associated GO terms

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .

GO term Namespace Name Definition Relationships
GO:0006457
Biological process Protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure.
Subterm of

Associated Lotus transcripts 7

Transcript Name Description Predicted domains Domain count
Lj0g3v0115109.1
– PREDICTED: protein grpE-like [Glycine max] gi|356515837|ref|XP_003526604.1|
Domains
16
Lj6g3v0820190.1
– PREDICTED: protein GrpE-like [Cicer arietinum] gi|502128881|ref|XP_004500111.1|
Domains
17
LotjaGi1g1v0024700.1
– GrpE protein homolog; TAIR: AT4G26780.1 Co-chaperone GrpE family protein; Swiss-Prot: sp|Q11B39|GRPE_CHESB Protein GrpE; TrEMBL-Plants: tr|A0A0B2RV54|A0A0B2RV54_GLYSO GrpE protein homolog; Found in the gene: LotjaGi1g1v0024700
Domains
16
LotjaGi1g1v0024700.2
– GrpE protein homolog; TAIR: AT5G55200.1 Co-chaperone GrpE family protein; Swiss-Prot: sp|Q11B39|GRPE_CHESB Protein GrpE; TrEMBL-Plants: tr|A0A151U2B4|A0A151U2B4_CAJCA GrpE protein homolog; Found in the gene: LotjaGi1g1v0024700
Domains
16
LotjaGi1g1v0249200.1
– GrpE protein homolog; TAIR: AT1G36390.1 Co-chaperone GrpE family protein; Swiss-Prot: sp|Q7UA77|GRPE_SYNPX Protein GrpE; TrEMBL-Plants: tr|I3RZM9|I3RZM9_LOTJA GrpE protein homolog; Found in the gene: LotjaGi1g1v0249200
Domains
16
LotjaGi1g1v0651200.1
– GrpE protein homolog; TAIR: AT5G17710.2 Co-chaperone GrpE family protein; Swiss-Prot: sp|A2BZB9|GRPE_PROM1 Protein GrpE; TrEMBL-Plants: tr|A0A0L9U758|A0A0L9U758_PHAAN GrpE protein homolog; Found in the gene: LotjaGi1g1v0651200
Domains
17
LotjaGi6g1v0154200.1
– GrpE protein homolog; TAIR: AT5G55200.1 Co-chaperone GrpE family protein; Swiss-Prot: sp|Q8YEV0|GRPE_BRUME Protein GrpE; TrEMBL-Plants: tr|A0A151SBL3|A0A151SBL3_CAJCA GrpE protein homolog; Found in the gene: LotjaGi6g1v0154200
Domains
17

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space:

Predicted domain Source Observations Saturation (%)
mobidb-lite MobiDBLite 1 14.29