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IPR010334 is a mRNA-decapping enzyme subunit 1.
<p>An essential step in mRNA turnover is decapping. In yeast, two proteins have been identified that are essential for decapping, Dcp1 (this family) and Dcp2. Dcp1 is a coactivator that binds to the decapping enzyme Dcp2 and forms a decapping enzyme complex, which removes the 5' cap structure from mRNAs prior to their degradation [[cite:PUB00033653]]. Yeast Dcp1 interact directly with Dcp2, however, the Dcp1-Dcp2 interaction is promoted by an additional factor, EDC4 [[cite:PUB00076141]]. In the nervous system, it promotes neurons' lifespan through the negative regulation of the insulin-like peptide ins-7 expression [[cite:PUB00096644]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Biological process | Deadenylation-dependent decapping of nuclear-transcribed mRNA | Cleavage of the 5'-cap of a nuclear mRNA triggered by shortening of the poly(A) tail to below a minimum functional length. | ||
| Molecular function | Enzyme activator activity | Binds to and increases the activity of an enzyme. | ||
| Biological process | Positive regulation of catalytic activity | Any process that activates or increases the activity of an enzyme. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: mRNA-decapping enzyme-like protein-like isoform X1 [Cicer arietinum] gi|502111997|ref|XP_004494216.1| | 8 | ||
| – | MRNA-decapping enzyme-like protein [Medicago truncatula] gi|357453179|ref|XP_003596866.1| | 8 | ||
| – | PREDICTED: mRNA-decapping enzyme-like protein-like [Cicer arietinum] gi|502083501|ref|XP_004487479.1| | 5 | ||
| – | MRNA-decapping enzyme-like protein; TAIR: AT1G08370.1 decapping 1; Swiss-Prot: sp|Q9SJF3|DCP1_ARATH mRNA-decapping enzyme-like protein; TrEMBL-Plants: tr|A0A151S1B1|A0A151S1B1_CAJCA mRNA-decapping enzyme-like protein; Found in the gene: LotjaGi1g1v0733900 | 8 | ||
| – | MRNA-decapping enzyme-like protein; TAIR: AT1G08370.1 decapping 1; Swiss-Prot: sp|Q9SJF3|DCP1_ARATH mRNA-decapping enzyme-like protein; TrEMBL-Plants: tr|A0A1J7I5L7|A0A1J7I5L7_LUPAN Uncharacterized protein; Found in the gene: LotjaGi3g1v0180000 | 9 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| mobidb-lite | MobiDBLite | 1 | 20.00 |