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IPR010347 is a Tyrosyl-DNA phosphodiesterase I.
<p>Tyrosyl-DNA phosphodiesterase 1 (Tdp1) is a DNA repair enzyme that can remove a variety of covalent adducts from DNA through hydrolysis of a 3'-phosphodiester bond, giving rise to DNA with a free 3' phosphate [[cite:PUB00069456], [cite:PUB00069457]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Cellular component | Nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. | ||
| Biological process | DNA repair | The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. | ||
| Molecular function | Phosphoric diester hydrolase activity | Catalysis of the hydrolysis of a phosphodiester to give a phosphomonoester and a free hydroxyl group. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: tyrosyl-DNA phosphodiesterase 1-like isoform X1 [Cicer arietinum] gi|502103206|ref|XP_004492226.1| | 15 | ||
| – | Tyrosyl-DNA phosphodiesterase [Medicago truncatula] gi|357520291|ref|XP_003630434.1| | 15 | ||
| – | Tyrosyl-DNA phosphodiesterase [Medicago truncatula] gi|357520291|ref|XP_003630434.1| | 21 | ||
| – | Tyrosyl-DNA phosphodiesterase [Medicago truncatula] gi|357520291|ref|XP_003630434.1| | 15 | ||
| – | Tyrosyl-DNA phosphodiesterase [Medicago truncatula] gi|357520291|ref|XP_003630434.1| | 14 | ||
| – | Tyrosyl-DNA phosphodiesterase 1; TAIR: AT5G15170.1 tyrosyl-DNA phosphodiesterase-like protein; Swiss-Prot: sp|Q8H1D9|TYDP1_ARATH Tyrosyl-DNA phosphodiesterase 1; TrEMBL-Plants: tr|G7KVX8|G7KVX8_MEDTR Tyrosyl-DNA phosphodiesterase; Found in the gene: LotjaGi1g1v0596400 | 16 | ||
| – | Tyrosyl-DNA phosphodiesterase 1; TAIR: AT5G15170.1 tyrosyl-DNA phosphodiesterase-like protein; Swiss-Prot: sp|Q8H1D9|TYDP1_ARATH Tyrosyl-DNA phosphodiesterase 1; TrEMBL-Plants: tr|G7KVX8|G7KVX8_MEDTR Tyrosyl-DNA phosphodiesterase; Found in the gene: LotjaGi1g1v0596400 | 16 | ||
| – | Tyrosyl-DNA phosphodiesterase 1; TAIR: AT5G07400.1 forkhead-associated domain-containing protein / FHA domain-containing protein; Swiss-Prot: sp|Q9NUW8|TYDP1_HUMAN Tyrosyl-DNA phosphodiesterase 1; TrEMBL-Plants: tr|G7LGI2|G7LGI2_MEDTR Tyrosyl-DNA phosphodiesterase; Found in the gene: LotjaGi4g1v0416500 | 21 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| cd09123 | CDD | 1 | 12.50 |