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IPR011274 is a Malate dehydrogenase, NAD-dependent, cytosolic.
<p>Malate dehydrogenase (MDH) is one of the key enzymes in the citric acid cycle, facilitating both the conversion of malate to oxaloacetate and replenishing levels of oxalacetate by reductive carboxylation of pyruvate [[cite:PUB00021813]]. There are several isoforms of MDH, differing in their subcellular localization and their specificity for the cofactor NAD or NADP [[cite:PUB00080844]]. Members of this family are eukaryotic NAD-dependent MDHs localized to the cytoplasm and cytosol.</p> <p>The enzyme from pig has been studied by X-ray crystallography [[cite:PUB00000309]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Biological process | Malate metabolic process | The chemical reactions and pathways involving malate, the anion of hydroxybutanedioic acid, a chiral hydroxydicarboxylic acid. The (+) enantiomer is an important intermediate in metabolism as a component of both the TCA cycle and the glyoxylate cycle. | ||
| Molecular function | L-malate dehydrogenase activity | Catalysis of the reaction: (S)-malate + NAD+ = oxaloacetate + NADH + H+. | ||
| Biological process | Oxidation-reduction process | A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: malate dehydrogenase, cytoplasmic-like [Cicer arietinum] gi|502155536|ref|XP_004510111.1| | 27 | ||
| – | Cytosolic malate dehydrogenase [Lupinus angustifolius] gi|328908589|gb|AEB60994.1| | 21 | ||
| – | PREDICTED: malate dehydrogenase, cytoplasmic-like [Cicer arietinum] gi|502122643|ref|XP_004497846.1| | 21 | ||
| – | Malate dehydrogenase; TAIR: AT5G56720.1 Lactate/malate dehydrogenase family protein; Swiss-Prot: sp|Q08062|MDHC_MAIZE Malate dehydrogenase, cytoplasmic; TrEMBL-Plants: tr|G7LBJ9|G7LBJ9_MEDTR Cytoplasmic-like malate dehydrogenase; Found in the gene: LotjaGi3g1v0554700 | 27 | ||
| – | Malate dehydrogenase; TAIR: AT5G43330.1 Lactate/malate dehydrogenase family protein; Swiss-Prot: sp|O48905|MDHC_MEDSA Malate dehydrogenase, cytoplasmic; TrEMBL-Plants: tr|F5B9G0|F5B9G0_LUPAN Malate dehydrogenase; Found in the gene: LotjaGi5g1v0190900 | 22 | ||
| – | Malate dehydrogenase; TAIR: AT5G43330.1 Lactate/malate dehydrogenase family protein; Swiss-Prot: sp|O48905|MDHC_MEDSA Malate dehydrogenase, cytoplasmic; TrEMBL-Plants: tr|U5G3W6|U5G3W6_POPTR Malate dehydrogenase; Found in the gene: LotjaGi5g1v0190900 | 21 | ||
| – | Malate dehydrogenase; TAIR: AT5G43330.1 Lactate/malate dehydrogenase family protein; Swiss-Prot: sp|O48905|MDHC_MEDSA Malate dehydrogenase, cytoplasmic; TrEMBL-Plants: tr|I3SCX2|I3SCX2_LOTJA Malate dehydrogenase; Found in the gene: LotjaGi6g1v0005300 | 21 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| cd01336 | CDD | 1 | 14.29 |