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IPR010945 is a Malate dehydrogenase, type 2.
<p>Malate dehydrogenases catalyse the interconversion of malate and oxaloacetate using dinucleotide cofactors [[cite:PUB00027655]]. The enzymes in this entry are found in archaea, bacteria and eukaryotes and fall into two distinct groups. The first group are cytoplasmic, NAD-dependent enzymes which participate in the citric acid cycle ([ec:1.1.1.37]). The second group are found in plant chloroplasts, use NADP as cofactor, and participate in the C4 cycle ([ec:1.1.1.82]).</p> <p>Structural studies indicate that these enzymes are homodimers with very similar overall topology, though the chloroplast enzymes also have N- and C-terminal extensions, and all contain the classical Rossman fold for NAD(P)H binding [[cite:PUB00021232], [cite:PUB00023558], [cite:PUB00013757], [cite:PUB00023967]]. Substrate specificity is determined by a mobile loop at the active site which uses charge balancing to discriminate between the correct substrates (malate and oxaloacetate) and other potential oxo/hydroxyacid substrates the enzyme may encounter within the cell [[cite:PUB00019781]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Biological process | Malate metabolic process | The chemical reactions and pathways involving malate, the anion of hydroxybutanedioic acid, a chiral hydroxydicarboxylic acid. The (+) enantiomer is an important intermediate in metabolism as a component of both the TCA cycle and the glyoxylate cycle. | ||
| Molecular function | Malate dehydrogenase activity | Catalysis of the reversible conversion of pyruvate or oxaloacetate to malate. | ||
| Biological process | Oxidation-reduction process | A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | Malate dehydrogenase [Medicago truncatula] gi|358348259|ref|XP_003638165.1| | 8 | ||
| – | PREDICTED: malate dehydrogenase [NADP] gi|356535509|ref|XP_003536287.1| | 8 | ||
| – | PREDICTED: malate dehydrogenase, cytoplasmic-like [Cicer arietinum] gi|502155536|ref|XP_004510111.1| | 27 | ||
| – | Cytosolic malate dehydrogenase [Lupinus angustifolius] gi|328908589|gb|AEB60994.1| | 21 | ||
| – | PREDICTED: malate dehydrogenase [NADP] gi|356535509|ref|XP_003536287.1| | 8 | ||
| – | PREDICTED: malate dehydrogenase, cytoplasmic-like [Cicer arietinum] gi|502122643|ref|XP_004497846.1| | 21 | ||
| – | Malate dehydrogenase; TAIR: AT5G56720.1 Lactate/malate dehydrogenase family protein; Swiss-Prot: sp|Q08062|MDHC_MAIZE Malate dehydrogenase, cytoplasmic; TrEMBL-Plants: tr|G7LBJ9|G7LBJ9_MEDTR Cytoplasmic-like malate dehydrogenase; Found in the gene: LotjaGi3g1v0554700 | 27 | ||
| – | Malate dehydrogenase; TAIR: AT5G43330.1 Lactate/malate dehydrogenase family protein; Swiss-Prot: sp|Q08062|MDHC_MAIZE Malate dehydrogenase, cytoplasmic; TrEMBL-Plants: tr|A0A0L9VUQ6|A0A0L9VUQ6_PHAAN Malate dehydrogenase; Found in the gene: LotjaGi3g1v0554700 | 16 | ||
| – | Malate dehydrogenase; TAIR: AT5G56720.1 Lactate/malate dehydrogenase family protein; Swiss-Prot: sp|Q08062|MDHC_MAIZE Malate dehydrogenase, cytoplasmic; TrEMBL-Plants: tr|G7LBJ9|G7LBJ9_MEDTR Cytoplasmic-like malate dehydrogenase; Found in the gene: LotjaGi3g1v0554700 | 24 | ||
| – | Malate dehydrogenase; TAIR: AT5G43330.1 Lactate/malate dehydrogenase family protein; Swiss-Prot: sp|O48905|MDHC_MEDSA Malate dehydrogenase, cytoplasmic; TrEMBL-Plants: tr|F5B9G0|F5B9G0_LUPAN Malate dehydrogenase; Found in the gene: LotjaGi5g1v0190900 | 22 | ||
| – | Malate dehydrogenase; TAIR: AT5G43330.1 Lactate/malate dehydrogenase family protein; Swiss-Prot: sp|O48905|MDHC_MEDSA Malate dehydrogenase, cytoplasmic; TrEMBL-Plants: tr|U5G3W6|U5G3W6_POPTR Malate dehydrogenase; Found in the gene: LotjaGi5g1v0190900 | 21 | ||
| – | Malate dehydrogenase; TAIR: AT5G58330.2 lactate/malate dehydrogenase family protein; Swiss-Prot: sp|O48902|MDHP_MEDSA Malate dehydrogenase [NADP], chloroplastic; TrEMBL-Plants: tr|A0A0R0HW29|A0A0R0HW29_SOYBN Uncharacterized protein; Found in the gene: LotjaGi5g1v0254100 | 19 | ||
| – | Malate dehydrogenase; TAIR: AT5G43330.1 Lactate/malate dehydrogenase family protein; Swiss-Prot: sp|O48905|MDHC_MEDSA Malate dehydrogenase, cytoplasmic; TrEMBL-Plants: tr|I3SCX2|I3SCX2_LOTJA Malate dehydrogenase; Found in the gene: LotjaGi6g1v0005300 | 21 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| cd01336 | CDD | 1 | 7.69 |