Description

IPR001252 is a Malate dehydrogenase, active site.

<p>Malate dehydrogenase ([ec:1.1.1.37]) (MDH) [[cite:PUB00000626]] catalyzes the interconversion of malate to oxaloacetate utilizing the NAD/NADH cofactor system. The enzyme participates in the citric acid cycle and exists in all aerobics organisms.</p> <p>While prokaryotic organisms contains a single form of MDH, in eukaryotic cells there are two isozymes: one which is located in the mitochondrial matrix and the other in the cytoplasm. Fungi and plants also harbor a glyoxysomal form which functions in the glyoxylate pathway. In plants chloroplast there is an additional NADP-dependent form of MDH ([ec:1.1.1.82]) which is essential for both the universal C3 photosynthesis (Calvin) cycle and the more specialised C4 cycle.</p> <p>The pattern for this enzyme includes two residues involved in the catalytic mechanism [[cite:PUB00000309]]: an aspartic acid which is involved in a proton relay mechanism, and an arginine which binds the substrate.</p>

This description is obtained from EB-eye REST.

Associated GO terms

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on April 27, 2020, while the GO metadata was last updated on April 27, 2020.

Associated Lotus transcripts 28

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space: