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IPR011323 is a Mss4/translationally controlled tumour-associated TCTP.
<p>This superfamily represents a structural domain with a complex fold consisting of several coiled β-sheets. This domain exists as a duplication, consisting of a tandem repeat of two similar structural motifs. This entry represents copies of this structural motif in the following protein families:</p> <ul> <li>Mss4, which contains a zinc-binding site.</li> <li>Translationally controlled tumour-associated protein TCTP, which contains an insertion of an α-helix hairpin, and which lacks a zinc-binding site.</li> </ul> <p>Mss4 is a conserved accessory factor for Rab GTPases, which function as ubiquitous regulators of intracellular membrane trafficking [[cite:PUB00014250]]. Mss4 acts to promote nucleotide release from exocytic but not endocytic Rab GTPases. Mss4 has a complex fold made of several coiled β-sheets, and consists of a duplication of tandem repeats of two similar structural motifs. It contains a zinc-binding site.</p> <p>Other proteins that show structural similarity to Mss4 include the translationally controlled tumour-associated proteins TCTPs, which contain an insertion of an α helical hairpin, and lack the zinc-binding site. TCTPs are a highly conserved and abundantly expressed family of eukaryotic proteins that are implicated in both cell growth and the human acute allergic response [[cite:PUB00007168]].</p>
This description is obtained from EB-eye REST.
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | RecName: Full=Translationally-controlled tumor protein homolog; Short=TCTPgi|36963062|gb|AAQ87663.1| translationally controlled tumor protein [Elaeis guineensis] gi|75222628|sp|Q5J907.1|TCTP_ELAGV | 11 | ||
| – | Translationally-controlled tumor protein, putative; TAIR: AT3G16640.1 translationally controlled tumor protein; Swiss-Prot: sp|Q5J907|TCTP_ELAGV Translationally-controlled tumor protein homolog; TrEMBL-Plants: tr|I3SG51|I3SG51_LOTJA Uncharacterized protein; Found in the gene: LotjaGi4g1v0339900 | 14 | ||
| – | Translationally-controlled tumor protein, putative; TAIR: AT3G16640.1 translationally controlled tumor protein; Swiss-Prot: sp|Q5J907|TCTP_ELAGV Translationally-controlled tumor protein homolog; TrEMBL-Plants: tr|I3SG51|I3SG51_LOTJA Uncharacterized protein; Found in the gene: LotjaGi4g1v0339900 | 14 | ||
| – | Translationally controlled tumor protein; TAIR: AT3G16640.1 translationally controlled tumor protein; Swiss-Prot: sp|Q5J907|TCTP_ELAGV Translationally-controlled tumor protein homolog; TrEMBL-Plants: tr|A0A151U4Q6|A0A151U4Q6_CAJCA Translationally-controlled tumor protein isogeny; Found in the gene: LotjaGi5g1v0224700 | 14 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| SSF51316 | SUPERFAMILY | 1 | 25.00 |