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IPR034737 is a Translationally controlled tumour protein (TCTP) domain.
<p>The translationally controlled tumor proteins (TCTPs, such as p21, p23 and histamine releasing factor (HRF)) are a highly conserved and abundantly expressed family of eukaryotic proteins that are implicated in a variety of cellular functions, including microtubule stabilization, cell cycle, apoptosis, and cytokine release. TCTP is ubiquitously expressed in all eukaryotic organisms from protozoa such as Plasmodium sp. to plants and mammals [[cite:PUB00007168], [cite:PUB00084252], [cite:PUB00084253], [cite:PUB00084254]].</p> <p>The TCTP domain structure comprises four β-sheets, designated A-D, and three main helices, designated H1-H3, connected in a complex topology. A central feature of the structure is the four-stranded sheet A, against one face of which packs the three-stranded sheet B and the small helix H1. Helix H3 packs against part of the opposite face of sheet A. Helix H2 packs against helix H3 (forming an α-helical hairpin). The final major structural feature is the two-stranded sheet C, which protrudes from the core globular structure formed by the rest of the domain [[cite:PUB00007168]].</p> <p>This entry represents the TCTP domain.</p>
This description is obtained from EB-eye REST.
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | Translationally-controlled tumor protein, putative; TAIR: AT3G16640.1 translationally controlled tumor protein; Swiss-Prot: sp|Q5J907|TCTP_ELAGV Translationally-controlled tumor protein homolog; TrEMBL-Plants: tr|I3SG51|I3SG51_LOTJA Uncharacterized protein; Found in the gene: LotjaGi4g1v0339900 | 14 | ||
| – | Translationally-controlled tumor protein, putative; TAIR: AT3G16640.1 translationally controlled tumor protein; Swiss-Prot: sp|Q5J907|TCTP_ELAGV Translationally-controlled tumor protein homolog; TrEMBL-Plants: tr|I3SG51|I3SG51_LOTJA Uncharacterized protein; Found in the gene: LotjaGi4g1v0339900 | 14 | ||
| – | Translationally controlled tumor protein; TAIR: AT3G16640.1 translationally controlled tumor protein; Swiss-Prot: sp|Q5J907|TCTP_ELAGV Translationally-controlled tumor protein homolog; TrEMBL-Plants: tr|A0A151U4Q6|A0A151U4Q6_CAJCA Translationally-controlled tumor protein isogeny; Found in the gene: LotjaGi5g1v0224700 | 14 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| SSF51316 | SUPERFAMILY | 1 | 33.33 |