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IPR018105 is a Translationally controlled tumour protein.
<p>Mammalian translationally controlled tumour protein (TCTP) (or P23) is a protein which has been found to be preferentially synthesised in cells during the early growth phase of some types of tumour [[cite:PUB00000270], [cite:PUB00004349]], but which is also expressed in normal cells. The physiological function of TCTP is still not known. It was first identified as a histamine-releasing factor, acting in IgE +-dependent allergic reactions. In addition, TCTP has been shown to bind to tubulin in the cytoskeleton, has a high affinity for calcium, is the binding target for the antimalarial compound artemisinin, and is induced in vitamin D-dependent apoptosis. TCTP production is thought to be controlled at the translational as well as the transcriptional level [[cite:PUB00007167]].</p>
This description is obtained from EB-eye REST.
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | RecName: Full=Translationally-controlled tumor protein homolog; Short=TCTPgi|36963062|gb|AAQ87663.1| translationally controlled tumor protein [Elaeis guineensis] gi|75222628|sp|Q5J907.1|TCTP_ELAGV | 11 | ||
| – | Translationally-controlled tumor protein, putative; TAIR: AT3G16640.1 translationally controlled tumor protein; Swiss-Prot: sp|Q5J907|TCTP_ELAGV Translationally-controlled tumor protein homolog; TrEMBL-Plants: tr|I3SG51|I3SG51_LOTJA Uncharacterized protein; Found in the gene: LotjaGi4g1v0339900 | 14 | ||
| – | Translationally-controlled tumor protein, putative; TAIR: AT3G16640.1 translationally controlled tumor protein; Swiss-Prot: sp|Q5J907|TCTP_ELAGV Translationally-controlled tumor protein homolog; TrEMBL-Plants: tr|I3SG51|I3SG51_LOTJA Uncharacterized protein; Found in the gene: LotjaGi4g1v0339900 | 14 | ||
| – | Translationally controlled tumor protein; TAIR: AT3G16640.1 translationally controlled tumor protein; Swiss-Prot: sp|Q5J907|TCTP_ELAGV Translationally-controlled tumor protein homolog; TrEMBL-Plants: tr|A0A151U4Q6|A0A151U4Q6_CAJCA Translationally-controlled tumor protein isogeny; Found in the gene: LotjaGi5g1v0224700 | 14 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| SSF51316 | SUPERFAMILY | 1 | 25.00 |